Photobiomodulation in the Brain

Low-Level Laser (Light) Therapy in Neurology and Neuroscience

1st Edition - July 13, 2019
Editors: Michael R. Hamblin, Ying-Ying Huang
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 1 5 3 0 5 - 5
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 5 3 0 6 - 2

Photobiomodulation in the Brain: Low-Level Laser (Light) Therapy in Neurology and Neuroscience presents the fundamentals of photobiomodulation and the diversity of applicati… Read more

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Photobiomodulation in the Brain: Low-Level Laser (Light) Therapy in Neurology and Neuroscience presents the fundamentals of photobiomodulation and the diversity of applications in which light can be implemented in the brain. It will serve as a reference for future research in the area, providing the basic foundations readers need to understand photobiomodulation’s science-based evidence, practical applications and related adaptations to specific therapeutic interventions. The book covers the mechanisms of action of photobiomodulation to the brain, and includes chapters describing the pre-clinical studies and clinical trials that have been undertaken for diverse brain disorders, including traumatic events, degenerative diseases and psychiatric disorders.

Part I: Basic considerations and in vitro

1. Photobiomodulation therapy and the brain: an innovative tool for therapy and discovery
Praveen R. Arany

2. Theoretical neuroscience
Marcelo Victor Pires de Sousa, Marucia Chacur, Daniel Oliveira Martins and Carlo Rondinoni

3. Photobiomodulation of cultured primary neurons: role of cytochrome c oxidase
Margaret Wong-Riley and Huan Ling Liang

4. Photobiomodulation on cultured cortical neurons
Ying-Ying Huang and Michael R. Hamblin

5. Safety and penetration of light into the brain
Erica B Wang, Ramanjot Kaur, Manuel Fierro, Evan Austin, Linda Ramball Jones and Jared Jagdeo

6. Near-infrared photonic energy penetration—principles and practice
Theodore A. Henderson and Larry D. Morries

7. Light sources and dosimetry for the brain and whole body
James D. Carroll

8. Mechanisms of photobiomodulation in the brain
Michael R. Hamblin

Part II: Studies in animal models

9. Transcranial photobiomodulation for stroke in animal models
Luis De Taboada and Michael R. Hamblin

10. Photobiomodulation in photothrombotic stroke
Lorelei Tucker, Luodan Yang, Yong Li and Quanguang Zhang

11. Remote photobiomodulation as a neuroprotective intervention—harnessing the indirect effects of photobiomodulation
Luke Gordon, Boaz Kim, Claudia Petrucco, Ji Yeon Kim, Patrick Benson, Jonathan Stone and Daniel M. Johnstone

12. Photobiomodulation for traumatic brain injury in mouse models
Michael R. Hamblin

13. Photobiomodulation and mitochondria for traumatic brain injury in mouse models
Mei X. Wu and Michael R. Hamblin

14. Photobiomodulation for depression in animal models
Farzad Salehpour, Javad Mahmoudi, Saeed Sadigh-Eteghad and Paolo Cassano

15. Transcranial photobiomodulation treats Alzheimer’s disease in amyloid-β protein precursor transgenic mice
Luis De Taboada and Michael R. Hamblin

16. Low-level laser therapy to the bone marrow: a new therapeutic approach to neurodegenerative diseases
Amir Oron and Uri Oron

17. The experimental evidence for photobiomodulation-induced cellular and behavioral changes in animal models of Parkinson’s disease: a template for translation to patients
Nabil El Massri and John Mitrofanis

18. Effects of near-infrared low-level laser stimulation on neuronal excitability
Ljubica M. Konstantinovic and Sasa R. Filipovic

19. Photobiomodulation for multiple sclerosis in animal models
M.A. Tolentino and J.A. Lyons

20. Hepatic encephalopathy and photobiomodulation: experimental models and clinical features
Natalia Arias, Juan Dıaz Gonza´lez, Alberto Martın Pernıa and Jorge L Arias

21. Photobiomodulation in animal models of retinal injury and disease
Janis T. Eells

22. Transcranial photobiomodulation therapy for pain: animal models, dosimetry, mechanisms, perspectives
Marcelo Victor Pires de Sousa, Nathali Cordeiro Pinto and Elisabeth Mateus Yoshimura

Part III: Cinical studies

23. The challenge of effectively translating transcranial near-infrared laser therapy to treat acute ischemic stroke
Paul A. Lapchak

24. Effects of photobiomodulation on traumatic brain injury: proposed clinical assessment
Sherry Fox and Victoria Campbell

25. Transcranial, red/near-infrared light-emitting diode therapy for chronic traumatic brain injury and poststroke aphasia: clinical studies
Margaret A. Naeser, Paula I. Martin, Michael D. Ho, Maxine H. Krengel, Yelena Bogdanova, Jeffrey A. Knight, Andrea Fedoruk, Michael R. Hamblin and Bang-Bon Koo

26. Photobiomodulation as a potential therapeutic strategy for improving cognitive and functional outcomes in traumatic brain injury
Thomas J. Covey, David W. Shucard, Melissa Meynadasy, Thomas Mang and Praveen R. Arany

27. Advanced neuroimaging methods for assessment of low-level light therapy
Suk-tak Chan, Maria Gabriela Longo, Eva-Maria Ratai and Rajiv Gupta

28. Treatment of traumatic brain injury with near-infrared light
Larry D. Morries and Theodore A. Henderson

29. Photobiomodulation: a novel approach to treating Alzheimer’s disease
Lew Lim, Genane Loheswaran, Reza Zomorrodi, Anita Saltmarche and Linda Chao

30. Electroencephalography as the diagnostic adjunct to transcranial photobiomodulation
Reza Zomorrodi, Genane Loheswaran and Lew Lim

31. Can photobiomodulation enhance brain function in older adults?
Agnes S. Chan, Michael K. Yeung and Tsz L. Lee

32. Noninvasive neurotherapeutic treatment of neurodegeneration: integrating photobiomodulation and neurofeedback training
Marvin H. Berman, Trent Nichols, Jason Huang and Damir Nizamutdinov

33. Transcranial photobiomodulation therapy: observations from four movement disorder patients
Catherine Hamilton, David Hamilton, Frank Nicklason and John Mitrofanis

34. Cerebral blood flow in the elderly: impact of photobiomodulation
Afonso Shiguemi Inoue Salgado, Francisco Jose´ Cidral-Filho,
Daniel Fernandes Martins, Ivo I. Kerppers and Rodolfo Borges Parreira

35. Transcranial photobiomodulation for major depressive and anxiety disorders and for posttraumatic stress disorder
Marco Antonio Caldieraro and Paolo Cassano

36. Action at a distance: laser acupuncture and the brain
Nicholas Alexander Wise

37. Signature wounds of war: a case study
George Louis Lindenfeld and George Rozelle

38. Transcatheter intracerebral photobiomodulation in degenerative brain disorders: clinical studies (Part 1)
Ivan V. Maksimovich

39. Transcatheter intracerebral photobiomodulation in ischemic brain disorders: clinical studies (Part 2)
Ivan V. Maksimovich

40. Russian low level laser therapy techniques for brain disorders
Sergey V. Moskvin and Andrey V. Kochetkov

41. Laser treatment of central nervous system injuries: an update and prospects
L. Longo

42. Photobiomodulation treatment for brain disorders: posttraumatic stress disorder (PTSD) and dementia
Randy Lamartiniere, Rhett Bergeron, Ronald Aung-Din, Matthew Bennett, William Stephan and Louis Banas

43. What we don’t know and what the future holds
Michael R. Hamblin

Michael R. Hamblin

Michael R Hamblin Ph.D. is a Principal Investigator at the Wellman Center for Photomedicine at Massachusetts General Hospital, an Associate Professor of Dermatology at Harvard Medical School and is a member of the affiliated faculty of the Harvard-MIT Division of Health Science and Technology. He was trained as a synthetic organic chemist and received his PhD from Trent University in England. His research interests lie in the areas of photodynamic therapy (PDT) for infections, cancer, and heart disease and in low-level light therapy (LLLT) for wound healing, arthritis, traumatic brain injury and hair-regrowth. He directs a laboratory of around a sixteen post-doctoral fellows, visiting scientists and graduate students. His research program is supported by NIH, CDMRP, USAFOSR and CIMIT among other funding agencies. He has published 252 peer-reviewed articles, over 150 conference proceedings, book chapters and International abstracts and holds 8 patents. He is Associate Editor for 7 journals, on the editorial board of a further 12 journals and serves on NIH Study Sections. For the past 9 years Dr Hamblin has chaired an annual conference at SPIE Photonics West entitled "Mechanisms for low level light therapy" and he has edited the 9 proceedings volumes together with four other major textbooks on PDT and photomedicine. He has several other book projects in progress at various stages of completion. In 2011 Dr Hamblin was honored by election as a Fellow of SPIE.

Affiliations and expertise

Harvard Medical School, Cambridge, MA, USA

Ying-Ying Huang

Dr. Huang is an instructor at Harvard University. She completed her dermatology residency at Sun Yat-Sen University in Guangzhou, China and her postdoctoral work at the Wellman Center for Photomedicine in Massachusetts General Hospital and Harvard Medical School. She has years of experience in drug screening in vitro and in vivo cancer therapies and maintains research in clinical dermatology.

Affiliations and expertise

MD, Harvard Medical School, Cambridge, MA, USA