This is an overview of the fast-moving field of purinergic signalling through adenosine and ATP receptors.

Key Features

  • Authors are the leading authorities in their fields
  • Subject matter is important for understanding tissue protection
  • Subject matter is of intense interest for new drug development


Pharmacologists, immunologists, and biochemists

Table of Contents

  1. The structure of the adenosine receptors: implications for drug discovery
  2. J. Robert Lane, Veli-Pekka Jaakola, Adriaan P. IJzerman


  3. Adenosine Receptors in Health and Disease
  4. Stefania Gessi, Stefania Merighi, Katia Varani, and Pier Andrea Borea


  5. Adenosine and the Regulation of Metabolism and Body Temperature
  6. Bertil Fredholm, Stina M. Johansson and Ying-Qing Wang


  7. Regulation of Leukocyte Function by Adenosine Receptors
  8. Joel Linden


  9. Role of Adenosine A2B Receptors in Inflammation
  10. Igor Feoktistov and Italo Biaggioni


  11. Interplay of Hypoxia and A2B Adenosine Receptors in Tissue Protection
  12. Michael Koeppen, Tobias Eckle, and Holger Eltzschig


  13. Allosteric Modulation of Purine and Pyrimidine Receptors
  14. Kenneth Jacobson, Zhan-Guo Gao, Aniko Göblyös, and Adriaan IJzerman


  15. Molecular Mechanisms of Purine and Pyrimidine Nucleotide Release
  16. Eduardo R. Lazarowski, Juliana I. Sesma, Lucia Seminario-Vidal, and Silvia M. Kreda


  17. Impact of Ectoenzymes on Purinergic Signalling
  18. Filip Kukulski, Sébastien A. Lévesque, and Jean Sévigny


  19. Ectonucleotidases as Regulators of Purinergic Signaling in Inflammation and Thrombosis
  20. Simon C. Robson and Silvia Deaglio

  21. P2X Receptors in Health and Disease
  22. Geoffrey Burnstock and Charles Kennedy


  23. Molecular Pharmacology, Physiology, and Structure of the P2Y Receptors
  24. Ivar von Kügelgen and T. Kendall Harden2


  25. P2Y Recep


No. of pages:
© 2011
Academic Press
eBook ISBN:
Print ISBN:

About the series-volume-editors