Pharmacology of Cholinergic and Adrenergic Transmission

Proceedings of the Second International Pharmacological Meeting, August 20—23, 1963

1st Edition - January 1, 1965
Editors: G. B. Koelle, W. W. Douglas, A. Carlsson
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 1 - 8 5 3 9 - 2

Section on Pharmacology of the International Union of Physiological Sciences (SEPHAR), Proceedings of the Second International Pharmacological Meeting, August 20-23, 1963, Volume… Read more

Pharmacology of Cholinergic and Adrenergic Transmission

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Section on Pharmacology of the International Union of Physiological Sciences (SEPHAR), Proceedings of the Second International Pharmacological Meeting, August 20-23, 1963, Volume 3: Pharmacology of Cholinergic and Adrenergic Transmission focuses on the effects of drugs on muscles, nerve fibers, and the central nervous system. The selection first offers information on the role of sodium ions in the release of acetylcholine and the distribution and release of acetylcholine in muscles. Discussions focus on the effects of sodium deficiency on ACh release in perfused ganglia; effects of sodium pump inhibitors on ganglionic and myoneural transmission; distribution of ACh and choline acetylase in muscle; and ACh release after denervation. The text then ponders on the roles of acetylcholine and acetylcholinesterase in junctional transmission and correlated studies of monoamines and acetylcholinesterase in sympathetic ganglia, manifesting the distribution of adrenergic and cholinergic neurons. The publication examines the action of acetylcholine and related drugs on mammalian nonmyelinated nerve fibers; possible mechanisms of acetylcholine action in muscles; and electrophysiological analysis of cholinergic transmission in sympathetic ganglia. The text then reviews the interactions of cholinomimetic and cholinergic blocking drugs at sympathetic ganglia; evolution of cholinoreceptive sites of locomotor muscle; and pharmacological blocking of central cholinoreactive systems and the possibilities of its therapeutic application. The selection is a dependable source of data for readers interested in the pharmacology of cholinergic and adrenergic transmission.

List of Authors and Participants

Cholinergic Transmission

Section One

The Role of Sodium Ions in the Release of Acetylcholine

Distribution and Release of Acetylcholine in Muscle

The Roles of Acetylcholine and Acetylcholinesterase in Junctional Transmission

Correlated Studies of Monoamines and Acetylcholinesterase in Sympathetic Ganglia, Illustrating the Distribution of Adrenergic and Cholinergic Neurons

The Action of Acetylcholine and Related Drugs on Mammalian Non-Myelinated Nerve Fibers

Possible Mechanisms of Acetylcholine Action in Muscle

Chairman's Summing Up

Section Two

Electrophysiological Analysis of Cholinergic Transmission in Sympathetic Ganglia

Interactions of Cholinomimetic and Cholinergic Blocking Drugs at Sympathetic Ganglia

Acetylcholine as a Secretogogue: Calcium-Dependent Links in "Stimulus-Secretion Coupling" at the Adrenal Medulla and Submaxillary Gland

On the Evolution of Cholinoreceptive Sites of Locomotor Muscle

The Molecular Distribution of 14C-Decamethonium in and around the Motor Endplate and its Metabolism in Cats and Mice

Cholinergic Transmission in the Mammalian Central Nervous System

Pharmacological Blocking of Central Cholinoreactive Systems and the Possibilities of its Therapeutic Application

Chairman's Summing Up

Adrenergic Transmission

Section One

Introductory Remarks

Localization of Neuronal Monoamines at the Cellular Level

Drugs Interfering with the Formation of Adrenergic Transmitters

Metabolism and Inactivation of Noradrenaline and Adrenaline and the Effect of Drugs

Biochemical and Pharmacological Aspects of a New Series of Substances Interfering with Biosynthesis and Interaction of Catecholamines

The Role of the Membrane of Chromaffin Granules Isolated from the Adrenal Medulla

The Biphasic Effect of Phenothiazines on the Release of Adrenaline from Adrenomedullary Granules and its Dependence on pH

Chairman's Summing Up

Section Two

Effect of Drugs on the Storage Granules of Adrenergic Nerves

Effect of Drugs on Monoamine Uptake in Isolated Tissues

Effect of Drugs and Sympathetic Denervation on Noradrenaline Uptake and Binding in Animal Tissues

Drugs Interfering with the Storage and Release of Adrenergic Transmitters

Adrenergic Receptor Mechanisms

Adenyl Cyclase and Hormone Action

Functional Significance of Noradrenaline Depletion by α-Methyl Metatyrosine, Metaraminol and Dextro-Adrenaline

Chairman's Summing Up

Index