Pharmacology of Cardiac Function

Pharmacology of Cardiac Function

Section of Pharmacology of the International Union of Physiological Sciences

1st Edition - January 1, 1964

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  • Editor: Otto Krayer
  • eBook ISBN: 9781483164526

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Pharmacology of Cardiac Function brings together the proceedings of the Second International Pharmacological Meeting of the International Union of Physiological Sciences, held in Prague, Czechoslovakia, on August 20-23, 1963. The meeting provided a forum for discussing advances in the understanding of the pharmacology of cardiac function and addressed topics ranging from the link between muscle physiology and the heart to the development of tension in cardiac muscle. This volume is comprised of 21 chapters and begins with an overview of the structural aspects of contraction in cardiac and skeletal muscle, followed by a description of muscle physiology and its effect on the heart. The next section deals with the effects of drugs on the interval-strength relationship of heart muscle, paying particular attention to acetylstrophanthidin, levarterenol, and carbacliol as well as metabolic inhibitors. The nature of the restitution process occurring between beats in cardiac muscle is also considered. Subsequent chapters explore how the heart is affected by the action of the vagus and of acetylcholine and other parasympathomimetic drugs; membrane effects of epinephrine and digitalis; and the mode of action of antifibrillatory drugs. This book will be of particular value to pharmacologists and physiologists.

Table of Contents

  • Muscle Contraction

    Introductory Remarks

    Structural Aspects of Contraction in Cardiac and Skeletal Muscle

    Muscle Physiology and the Heart

    The Development of Tension in Cardiac Muscle

    Electrolytes and Myocardial Contractility

    Effects of Drugs on the Interval-Strength Relationship of Heart Muscle

    Importance of the Interval-Strength Relationship for the Evaluation of Cardiac Inotropic Effects of Drugs

    Descriptive Analysis of the Interval-Strength Relationship of Heart Muscle

    Effects of Acetylstrophanthidin, Levarterenol and Carbachol on the Interval-Strength Relationship of Heart Muscle

    Effects of Metabolic Inhibitors on the Interval-Strength Relationship

    Some Comments on the Nature of the Restitution Process Occurring between Beats in Cardiac Muscle

    Chairman's Concluding Remarks

    Impulse Generation and Conduction

    Introductory Remarks

    The Action of the Vagus, of Acetylcholine and Other Parasympathomimetic Drugs on the Heart

    Membrane Effects of Epinephrine in the Heart

    The Importance of the Norepinephrine Stores for the Action of Various Cardio-active Drugs

    Membrane Effects of Digitalis

    Effect of Ouabain on Cardiac Contraction, Action Potential and Cellular Potassium

    Mechanism of Fibrillation in a Mathematical Model

    The Mode of Action of Antifibrillatory Drugs

    Fibrillatory and Antifibrillatory Drugs

    Discussion of Dr. West's Paper


Product details

  • No. of pages: 160
  • Language: English
  • Copyright: © Pergamon 1964
  • Published: January 1, 1964
  • Imprint: Pergamon
  • eBook ISBN: 9781483164526

About the Editor

Otto Krayer

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