Pharmacology in Drug Discovery

Pharmacology in Drug Discovery

Understanding Drug Response

1st Edition - September 1, 2011

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  • Author: Terry Kenakin
  • eBook ISBN: 9780123848574
  • Paperback ISBN: 9780123848567

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Pharmacology in Drug Discovery: Understanding Drug Response is designed for all students, recent graduates, and new researchers in the pharmaceutical and biotechnology industries who need to interpret change in physiology induced by a chemical substance. Physiological systems customize chemical signal input to their own needs; therefore the same drug can have different effects in different physiological systems. The field of pharmacology is unique in that it furnishes the tools to analyze these different behaviors and traces them to their root cause. This enables predictions of drug behavior to be made in all systems, an invaluable tool for drug discovery because almost all drugs are developed in test systems far removed from the therapeutic one.  This valuable resource provides simple explanations of the ways in which biological systems use basic biochemical mechanisms to produce fine chemical control of physiology, allowing for more informed predictions of drug effects in all systems and forming the basis of the drug-discovery process. Chapters follow a logical progression on how to characterize the pharmacology of any given molecule, and include important terminology, chapter summaries, references, and review questions to aid the reader in understanding and retention of the material.

Key Features

  • Enables the reader to interpret drug dose-response data and make mechanistic inferences at the molecular level
  • Bridges the gap between biochemistry and therapeutic medicine
  • Chapters include key topics such as drug affinity and efficacy, enzymes as drug targets, in vivo pharmacology, safety pharmacology, and more


Recent graduates and new researchers in the pharmaceutical and biotechnology industries

Table of Contents

  • Dedication



    Chapter 1. Pharmacology

    Chapter 2. Drug Affinity and Efficacy

    Chapter 3. Predicting Agonist Effect

    Chapter 4. Drug Antagonism

    Chapter 5. Allosteric Drug Effects

    Chapter 6. Enzymes as Drug Targets

    Chapter 7. Pharmacokinetics I

    Chapter 8. Pharmacokinetics II

    Chapter 9. In Vivo Pharmacology

    Chapter 10. Safety Pharmacology

    Appendix A. Answers to Chapter Questions

    Appendix B. Derivations and Proofs


Product details

  • No. of pages: 260
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: September 1, 2011
  • Imprint: Academic Press
  • eBook ISBN: 9780123848574
  • Paperback ISBN: 9780123848567

About the Author

Terry Kenakin

Terry Kenakin
Dr. Terry Kenakin is Professor of Pharmacology at the University of North Carolina School of Medicine. Prior to this, he spent 7 years in drug discovery at Burroughs-Wellcome. He then moved to GlaxoSmithKline for 25 years. Dr. Kenakin has written 11 books on Pharmacology, is the Editor in Chief of the Journal of Receptors and Signal Transduction, is on numerous Editorial Boards. He is the Editor-in-Chief of Comprehensive Pharmacology (Elsevier, 2022). He is the recipient of the 2008 Poulsson Medal for Pharmacology awarded by the Norwegian Society of Pharmacology for achievements in basic and clinical pharmacology and toxicology. He has also been awarded the 2011 Ariens Award from the Dutch Pharmacological Society and the 2014 Gaddum Memorial Award from the British Pharmacological Society, and the 2020 Goodman and Gilman Award in Receptor Pharmacology from ASPET.

Affiliations and Expertise

Professor, Pharmacology, University of North Carolina, USA

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