Pharmacological Control of Heart and Circulation - 1st Edition - ISBN: 9780080263861, 9781483147789

Pharmacological Control of Heart and Circulation

1st Edition

Proceedings of the 3rd Congress of the Hungarian Pharmacological Society, Budapest, 1979

Editors: L. Tardos L. Szekeres J. Gy. Papp
eBook ISBN: 9781483147789
Imprint: Pergamon
Published Date: 1st January 1980
Page Count: 456
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Pharmacological Control of Heart and Circulation, Volume 1, documents the proceedings of the 3rd Congress of the Hungarian Pharmacological Society held in Budapest, 1979. Because the papers published in this volume cover diverse areas of the cardiovascular field, they had to be arranged into several smaller symposia. The common thread running through these symposia is their focus on some pathological condition of the heart and circulation as well as on their control by drugs. The first symposium is devoted to the pharmacological control of the adverse effects of coronary insufficiency including disturbances in rhythm. The second symposium is dedicated to cardiac hypertrophy; to the action of cardiac hypertrophy on the sensitivity of the heart to drugs; and to the changes in the biochemical parameters of the myocardium due to cardiomegaly. The third symposium deals with hypertension and its pharmacological control. Two separate symposia are devoted to new drugs, namely the fourth symposium to the cerebrovascular activity of Cavinton—a synthetic Vinca-derivative; and the fifth to a newly developed beta-adrenergic blocking agent, Tobanum, to its anti-arrhythmic action, its effect in myocardial ischemia and in hypertension. Finally, a short symposium on serotonin and serotonin antagonists, both of great importance in cardiovascular pharmacology, is included.

Table of Contents


Pharmacological Control of the Adverse Effects of Coronary Insufficiency

Pharmacological Control of the Adverse Effects of Coronary Insufficiency. Introduction

Metabolic Changes Due to Myocardial Ischemia

Effects of Ischemic Metabolites on the Mitochondrial Membrane

Antianginal and Antiarrhythmic Agents and Cellular Components

Effect of Myocardial Ischemia on the Basic Electrical Phenomena in the Heart Cell

Arrhythmogenic Action of Local Myocardial Ischemia

Significance of the Autonomic Nervous System in the Appearance of Arrhythmias Due to Coronary Occlusion

Influence of Hypothyroidism on Cardiac Arrhythmias Induced by Coronary Occlusion

Influence of Thyrotoxicosis on Disorders of Cardiac Rhythm Appearing in Coronary Insufficiency

Acute Effect of Antiarrhythmic Drugs in Heart Rhythm Disturbances Due to Myocardial Ischemia

Effect of Prolonged Treatment with Antiarrhythmic and Antianginal Drugs on the Incidence of Ventricular Fibrillation and Death in the Acute Phase of Myocardial Infarction in Awake Rats

Effect of Pentobarbitone Anaesthesia, Age, and Sex in the Acute Phase of Myocardial Infarction in Rats

Importance of Metabolic Changes in the Antianginal Effect of Drugs at the Subcellular Level

Significance of Metabolic Alterations in the Effect of Antianginal Drugs at the Cellular Level

Importance of Metabolic Changes in the Antianginal Action of Drugs at the Organ Level

Role of Haemodynamics in the Antianginal Action of Drugs

Effect of A Drug Combination in the Experimental Model of Angina Pectoris

Effect of Drugs on Cerebral Circulation in Chronic Cerebral Ischemia

Adrenergic Mechanisms in Coronary Vascular Control and Oxygen Metabolism Following Brief Regional Myocardial Ischemia

Cardiac Hypertrophy

Changes in the Contractility and Catecholamine-Sensitivity of Myocardium in Isoproterenolinduced Cardiac Hypertrophy

The Role of Thyroid stage in the Inotropic Effect of Adenosine on Ventricular Myocardium

Alteration of Catecholamine-Sensitivity in Thyroxine-Induced Myocardial Hypertrophy

Regulation of ß-Adrenergic Receptors in Heart Muscle. Some Aspects

Investigation on the Altered Properties of Myosin Associated with Cardiac Hypertrophy

Biochemical Parameters Related to Cardiomegaly

Studies on the Myosin ATPase Activity in Experimentally-Induced Cardiac Hypertrophy in Rats

Cardiac Arrhythmias Induced by Electrical and Chemical Stimulation of Some Hypothalamic Nuclei in the Rats

Hypertension-Pharmacological and Clinical Aspects

An Analysis of Antihypertensive Drugs

Pharmacologic Control of Hypertensive Emergencies

Some Studies on the Central Actions of Beta-Adrenoreceptor Blocking Drugs in Man

Mode of Action of Centrally Acting Antihypertensive Drugs

The Influence of Hypotensive Drugs on Adaptive Haemodynamic Reactions

The Cardiovascular Pattern of Clonidine-like Antihypertensive Substances and Their Mode of Action

Involvement of Presynaptic and Postsynaptic α-Adrenoceptors in the Action of Clonidine-like Substances

Tachyphylaxis to the Hypo Tensive Effect of Clonidine on Rats

Hypertensive Effect of Clonidine and Regional Noradrenaline Concentration in the Brain of Normotensive and Hypertensive Rats after Acute and Chronic Treatment

The Effect of Indomethacin on Renin-Angiotensin-Aldosterone System in Essential Hypertension

Cross-over Trial for Comparing Antihypertensive Effects of Prazosin and Hydralazine

Taurine and Hypertension

Planning of Antihypertensive Pyridazine Compounds

Pharmacology of GYKI-11.679, a New Antihypertensive Drug

The Antihypertensive Effect of Morpholino-Pyridazinyl-Hydrazine and Its Hydrazone Derivative

Pharmacological Control of Disseminated Intravascular Coagulation (DIC)

The Beta-Adrenergic Blocker Tobanum®

Pharmacology of GYKI-41099 (Chlorpropanol, Tobanum®). A New Potent Beta-Adrenergic Antagonist

Effects of Tobanum (GYKI-41099) on Cardiac Transmembrane Potentials

Human Pharmacokinetic Study on Tobanum®

Tobanum (GYKM1099) Effect on Intrinsic Heart Rate

An Tiarrhythmic Properties of Tobanum®. A New Beta-Blocking Agent

The Haemodynamic Effect of the Beta-Blocking Agent GYKI-41099 (Tobanum®) on Ischemic Cardiac Patients

Tobanum (GYKI-41099) in Hypertension - A Multicentre Clinical Trial

The Effect of GYKI-41099 on Plasma Renin Activity and Blood Pressure of Essential Hypertension

Comparative Study on Tobanum® (GYKI-41099) and Pindolol on Patients Suffering from Moderate or Severe Hypertension

Effect of GYKI-41099, A New Beta-Adrenergic Receptor Blocking Agent, on the Responses of Carotid Sinus Baroreceptor Reflex in Man

Studies on A New ß-Receptor Blocking Drug: Tobanum® (1-(2,5-Dichlorophenoxy)-3-Tertiary-butylaminopropanol-2-HCl). Experiences in Cardiovascular Hyperkinetic Syndrome and Angina Pectoris. Effect on the Respiration

Principles of Clinical Treatment with Tobanum (GYKI-41099) in Cardiac Dysrhythmias

Comparative Study of the Beta-Adrenergic Blocking Agents GYKI-41099 (Tobanum) and Propranolol in Thyrotoxic Patients

Serotonin and Serotonin Antagonists

On the Effects of Compound GYKI-32.594, A New Content Serotonin Antagonist 333

Effects of Drugs Affecting Serotonergic System on Activity of Central Dopaminergic and Serotonergic Systems in Rats

Dose-Dependent Opposite Effects of the 5-HT Receptor Antagonists on the 5-HT-Induced Responses in the Rat

Effects of Some Indolines in Comparison with Serotonin on the Guinea-Pig Isolated Ileum

Detection of 5-Hydroxytryptamine Receptors in Some Vascular Smooth Muscle Preparation

Clinical and Pharmacological Effects of Cavinton® and Related Compounds

The Modification of the Pathological Cerebral Circulation on the Effect of Cavinton

The Effect of Cavinton and Xavin on the Redox Changes in the Brain of Stroke Patients

Clinical Studies on Cavinton®

The Effect of Cavinton® in Ischemic Disturbances of the Cerebral Circulation

Treatment of Acute and Chronic Ischemic Cerebrovascular Disease with Cavinton

Evaluation of Cavinton Effects in Patients with Cerebral Vascular Lesions

The Value of Cavinton Therapy in Retinal and Choroidal Disorders

Effect of Ethyl-Apovincaminate on the Cochleovestibular System - A Comparative Investigation

Cerebral Circulatory, Antihypoxic and CNS Activity of Indole Derivatives

New Indole Derivatives Increase the Ability of the Brain to Tolerate the Effects of Serial Asphyxie Hypoxia in Rat

Biochemical Effects of Semi-Synthetic Vinca-Alkaloids on the Cyclic AMP System

A New Class of 3',5'-cAMP Phosphodiesterase Inhibitors: Apovincine Derivatives

Subject Index


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About the Editor

L. Tardos

L. Szekeres

J. Gy. Papp

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