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Pharmacogenomics
1st Edition
Challenges and Opportunities in Therapeutic Implementation
Table of Contents
Dedication
List of Contributors
Preface
Chapter 1. Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications
Objectives
Introduction
Cytochrome P-450 Enzymes
Non-CYP-450 Drug Metabolizing Enzymes
Polymorphisms in Drug Transporter Genes
Drug Target Genes
Conclusion
Questions for Discussion
References
Chapter 2. Translating Pharmacogenomic Research to Therapeutic Potentials
Objectives
Introduction
Implementation of Biomarkers in Clinical Practice
Incorporating Pharmacogenomics into Drug Development
Conclusion
Questions for Discussion
References
Chapter 3. Governmental and Academic Efforts to Advance the Field of Pharmacogenomics
Objectives
Introduction
The Role of the National Institutes of Health
The Role of the Food and Drug Administration and Other International Government Agencies
Activities of Non-U.S. Agencies
Conclusion
Questions for Discussion
References
Chapter 4. Pharmacogenomics in Cancer Therapeutics
Objectives
Introduction
Role of Oncology Biomarkers
Concepts in Targeted Cancer Therapy
Oncology in the Postgenomic Era
Challenges in Drug Development and Cancer Trials
Seeking Pharmacogenomic Value
Questions for Discussion
References
Chapter 4A. A Look to the Future: Cancer Epigenetics
Learning Objectives
Introduction
Histone Modification
DNA Methylation
Noncoding RNA (ncRNA)
Conclusion
Questions for Discussion
References
Chapter 5. Pharmacogenetics in Cardiovascular Diseases
Objectives
Introduction
Pharmacogenomics of Antiplatelet Agents
Warfarin Pharmacogenomics
Other
Details
- No. of pages:
- 510
- Language:
- English
- Copyright:
- © 2013
- Published:
- 14th March 2013
- Imprint:
- Academic Press
- eBook ISBN:
- 9780123983039
- Print ISBN:
- 9780123919182
About the editors
Yui-Wing Francis Lam
Dr. Lam is Professor of Pharmacology at the University of Texas Health Science Center San Antonio (UTHSCSA). His editing experience included the first edition of Pharmacogenomics as well as being the lead editor of another published book entitled “Herbal Supplements – Drug Interactions. Scientific and Regulatory Perspectives”. He is also a co-author for a book chapter on pharmacogenetics in six consecutive editions of the textbook “Pharmacotherapy: A Pathophysiologic Approach”. Dr. Lam designed and continues to direct a graduate course “Molecular and Pharmacological Basis of Therapeutics” since 2002 for the UTHSCSA and the College of Pharmacy at the University of Texas at Austin. He has organized and participated in international and national symposia on topics related to personalized and molecular medicine, and is a scientific councilor for the Pacific Rim Association for Clinical Pharmacogenetics.
Affiliations and Expertise
PharmD, Professor of Pharmacology, Department of Pharmacology and Associate Professor, Department of Medicine, The University of Texas Health Science Center at San Antonio
Larisa Cavallari
Affiliations and Expertise
PharmD, Associate Professor, Department of Pharmacy Practice, University of Illinois at Chicago
Reviews
"...a practical and indispensable resource on both the opportunities and challenges that allows readers to reflect on the future direction of pharmacogenomics while applying these observations to their own work or research."--Anticancer Research, February 2015
"Lam and Cavallari bring together pharmacy and other specialists from North America, Europe, and Asia for 13 chapters aimed at scientists, clinicians, and students in health and pharmaceutical sciences. The chapters consider the translation of pharmacogenomic findings into therapeutic applications from academic, regulatory, pharmaceutical, clinical, socioethical, and economic perspectives."--Reference and Research Book News, August 2013
"This book succeeds in providing a relevant and unique perspective, by international experts in the field, on the progress and challenges facing the translation of pharmacogenomics into clinical practice. I highly recommended it to anyone with an interest in the topic, from the essential basics to its role in the future practice of medicine."--Doody.com, August 2, 2013
"…this latest state-of-the-art book on pharmacogenomics successfully tackles the objectives described by its title. The key feature of the book is the in-depth discussion on a range of challenges currently facing pharmacogenomics in the widely publicised revolution in drug therapy… the Editors and the contributors are to be congratulated for their offering and this excellent book should serve well the needs of all those interested in the potential role of pharmacogenomic revolution in personalizing therapy…" – British Journal of Clinical Pharmacology, November 5, 2013