Pharmacogenomics - 2nd Edition - ISBN: 9780128126264


2nd Edition

Challenges and Opportunities in Therapeutic Implementation

Editors: Yui-Wing Francis Lam Scott Stuart
Hardcover ISBN: 9780128126264
Imprint: Academic Press
Published Date: 1st October 2018
Page Count: 544
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Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation, Second Edition provides comprehensive coverage of the challenges and opportunities facing the therapeutic implications of pharmacogenomics from academic, regulatory, pharmaceutical, socio-ethical and economic perspectives. While emphasis is on the limitations in moving the science into drug development and direct therapeutic applications, this book also focuses on clinical areas with successful applications and important initiatives that have the ability to further advance the discipline. New chapters cover important topics such as the challenge of integrating epigenetics into pharmacogenomics research, pharmacoeconomics, cost-effectiveness and reimbursement. The issue of ethnicity and ethno-bridging in translating and implementing scientific findings worldwide is also discussed. With chapters written by interdisciplinary experts and containing insight into the future direction of the field, this book is an indispensable resource for academic and industry scientists, graduate students and clinicians engaged in pharmacogenomics research and therapeutic implementation.

Key Features

  • Provides viewpoints that focus on the scientific and translational challenges and opportunities associated with advancing the field of pharmacogenomics
  • This new edition highlights progress in both the research and clinical areas of pharmacogenomics, as well as relevant implementation experience and challenges, and perspectives on direct-to-consumer genetic testing
  • Includes discussion points and review questions along with clinical pearls or cases for self-assessment purposes or to facilitate in-depth discussion


Scientific researchers in academia and the pharmaceutical industry, as well as health care clinicians. Also, graduate students in pharmaceutical science, pharmacy and health sciences

Table of Contents

Section I: Introduction
1. Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications
2. Governmental and Academic Efforts to Advance the Field of Pharmacogenomics
3. Molecular Approaches, Models, and Techniques in Pharmacogenomic Research and Development
4. Study Designs in Pharmacogenomics Research
5. Incorporating Pharmacogenomics in Drug Development: Industry and Regulatory Perspectives

Section II: Clinical Pharmacogenomics
6. Translating Pharmacogenomic Research to Therapeutic Potentials - Ethical Considerations and Challenges in Pharmacogenomics
7. Pharmacogenomics in Cancer Therapeutics
8. Pharmacogenomics in Cardiovascular Diseases - Lessons Learned from Warfarin
9. Pharmacogenomics in Psychiatry Disorders - Lessons Learned from Antidepressants and Antipsychotics
10. Role of Pharmacogenomics in HIV Infection - Lessons Learned from Efavirenz
11. Role of Pharmacogenomics in Diabetes - Lessons Learned from Metformin?
12. A Look to the Future: Pharmacogenomics, Pharmacoepigenomics, and System Biology - Data Technologies of Today and Tomorrow

Section III: Practical Pharmacogenomics
13. The Importance of Race and Ethnicity in Pharmacogenomics
14. Reactive, Point-of-Care, Pre-emptive and Direct-to-Consumer Pharmacogenomic Testing
15. Cost-effectiveness and Pharmacogenomic Testing Reimbursement
16. Pharmacogenomics Education and Clinical Practice Guidelines


No. of pages:
© Academic Press 2019
Academic Press
Hardcover ISBN:

About the Editor

Yui-Wing Francis Lam

Dr. Lam is Professor of Pharmacology at the University of Texas Health Science Center San Antonio (UTHSCSA). His editing experience included the first edition of Pharmacogenomics as well as being the lead editor of another published book entitled “Herbal Supplements – Drug Interactions. Scientific and Regulatory Perspectives”. He is also a co-author for a book chapter on pharmacogenetics in six consecutive editions of the textbook “Pharmacotherapy: A Pathophysiologic Approach”. Dr. Lam designed and continues to direct a graduate course “Molecular and Pharmacological Basis of Therapeutics” since 2002 for the UTHSCSA and the College of Pharmacy at the University of Texas at Austin. He has organized and participated in international and national symposia on topics related to personalized and molecular medicine, and is a scientific councilor for the Pacific Rim Association for Clinical Pharmacogenetics.

Affiliations and Expertise

Professor of Pharmacology, Associate Professor of Medicine, Clinical Associate Professor, James O’Burke Endowed Centennial Fellow in Pharmacy, University of Texas Health Science Center, San Antonio, TX, USA

Scott Stuart

Dr. Stuart Scott will take on the co-editor role for this second edition. Dr. Scott is an Assistant Professor in the Department of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai, New York, where he oversees clinical pharmacogenetic testing as an ABMGG-certified Director of the Mount Sinai Genetic Testing Laboratory. His research interests include cardiovascular pharmacogenomics, multiethnic pharmacogenomic allele discovery, and long-read sequencing method development. He has co-authored Clinical Pharmacogenetics Implementation Consortium (CPIC) practice guidelines and is a member of other international genomics/pharmacogenomics consortia, and is a co-investigator of the Institute for Personalized Medicine (IPM) pharmacogenomics implementation program at Mount Sinai. He teaches pharmacogenetics to medical, graduate and genetic counseling students, clinical residents and fellows, and co-directs the comprehensive Translational Genomics graduate level course at Mount Sinai.

Affiliations and Expertise

Assistant Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, NY, USA

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