Challenges and Opportunities in Therapeutic Implementation

2nd Edition - November 27, 2018

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  • Editors: Yui-Wing Francis Lam, Stuart Scott
  • eBook ISBN: 9780128126271
  • Hardcover ISBN: 9780128126264

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Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation, Second Edition, provides comprehensive coverage of the challenges and opportunities facing the therapeutic implications of pharmacogenomics from academic, regulatory, pharmaceutical, socio-ethical and economic perspectives. While emphasis is on the limitations in moving the science into drug development and direct therapeutic applications, this book also focuses on clinical areas with successful applications and important initiatives that have the ability to further advance the discipline. New chapters cover important topics such as pharmacogenomic data technologies, clinical testing strategies, cost-effectiveness, and pharmacogenomic education and practice guidelines. The importance of ethnicity is also discussed, which highlights phar,acogenomic diversity across Latin American populations.With chapters written by interdisciplinary experts and insights into the future direction of the field, this book is an indispensable resource for academic and industry scientists, graduate students and clinicians engaged in pharmacogenomics research and therapeutic implementation.

Key Features

  • Provides viewpoints that focus on the scientific and translational challenges and opportunities associated with advancing the field of pharmacogenomics
  • Highlights progress in both the research and clinical areas of pharmacogenomics, as well as relevant implementation experience, challenges, and perspectives on direct-to-consumer genetic testing
  • Includes, where applicable, discussion points, review questions, and cases for self-assessment purposes and to facilitate in-depth discussion


Scientific researchers in academia and the pharmaceutical industry, as well as health care clinicians. Also, graduate students in pharmaceutical science, pharmacy and health sciences

Table of Contents

  • 1. Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications
    2. Governmental and Academic Efforts to Advance the Field of Pharmacogenomics
    3. Incorporating Pharmacogenomics in Drug Development: Industry and Regulatory Perspectives
    4. Translating Pharmacogenomic Research to Therapeutic Potentials
    5. Pharmacogenomics in Cancer Therapeutics
    6. Pharmacogenomics in Cardiovascular Diseases
    7. Pharmacogenomics in Psychiatry Disorders
    8. Role of Pharmacogenomics in HIV Infection
    9. Role of Pharmacogenomics in Diabetes
    10. A Look to the Future: Pharmacogenomics, Pharmacoepigenomics, and System Biology - Data Technologies of Today and Tomorrow
    11. The Importance of Ethnicity Definitions and Pharmacogenomics in Ethnobridging and Pharmacovigilance
    12. Pharmacogenomics in Latin American Population
    13. Reactive, Point-of-Care, Pre-emptive and Direct-to-Consumer Pharmacogenomic Testing
    14. Economic Evaluation of Pharmacogenomic Testing: Lessons from Psychiatric Pharmacogenomics
    15. Pharmacogenomics Education and Clinical Practice Guidelines

Product details

  • No. of pages: 442
  • Language: English
  • Copyright: © Academic Press 2018
  • Published: November 27, 2018
  • Imprint: Academic Press
  • eBook ISBN: 9780128126271
  • Hardcover ISBN: 9780128126264

About the Editors

Yui-Wing Francis Lam

Dr. Lam is Professor of Pharmacology at the University of Texas Health Science Center San Antonio (UTHSCSA). His editing experience included the first edition of Pharmacogenomics as well as being the lead editor of another published book entitled “Herbal Supplements – Drug Interactions. Scientific and Regulatory Perspectives”. He is also a co-author for a book chapter on pharmacogenetics in six consecutive editions of the textbook “Pharmacotherapy: A Pathophysiologic Approach”. Dr. Lam designed and continues to direct a graduate course “Molecular and Pharmacological Basis of Therapeutics” since 2002 for the UTHSCSA and the College of Pharmacy at the University of Texas at Austin. He has organized and participated in international and national symposia on topics related to personalized and molecular medicine, and is a scientific councilor for the Pacific Rim Association for Clinical Pharmacogenetics.

Affiliations and Expertise

Professor of Pharmacology, Minnie Stevens Piper Professor (2018), James O’Burke Endowed Centennial, Fellow in Pharmacy, University of Texas Health Science Center, San Antonio, TX, USA

Stuart Scott

Dr. Stuart A. Scott will take on the co-editor role for this second edition. Dr. Scott is an Associate Professor in the Department of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai, New York, and is the Division Head of Pharmacogenomics at the Sema4 clinical genetic testing laboratory. His research interests include multiethnic pharmacogenomic allele discovery, cytogenomics, and long-read sequencing method development. He is a member of several international genomic medicine and pharmacogenomics consortia, has co-authored Clinical Pharmacogenetics Implementation Consortium (CPIC) practice guidelines, and is a co-investigator of the Mount Sinai Institute for Personalized Medicine (IPM) pharmacogenomics implementation program. In addition, he teaches pharmacogenomics and clinical genetics to genetic counseling students, graduate and medical students, clinical residents, and fellows by lecturing for several courses at Mount Sinai and other institutions.

Affiliations and Expertise

Associate Professor, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Division Head, Pharmacogenomics, Sema4, Stamford, CT, USA

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