Pharmaceutics - 1st Edition - ISBN: 9780123868909, 9780123868916


1st Edition

Basic Principles and Application to Pharmacy Practice

Editors: Alekha Dash Somnath Singh Justin Tolman
Hardcover ISBN: 9780123868909
eBook ISBN: 9780123868916
Imprint: Academic Press
Published Date: 31st October 2013
Page Count: 392
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Pharmaceutics: Basic Principles and Application to Pharmacy Practice is a valuable textbook covering the basic science as well as the role and application of pharmaceutics within pharmacy practice. Based on curricular guidelines mandated by the American Council for Pharmacy Education (ACPE), this book incorporates laboratory skills by identifying portions of each principle that can be used in a clinical setting. In this way, instructors are able to demonstrate their adherence to ACPE standards and objectives simply by using this book. A companion website for students and instructors further enhance the didactic content for students by including practice questions and answers and videos that feature difficult processes and procedures. Essential resources for instructors are also available and include chapter PowerPoint slides and full-color images. Full of practical examples and case studies for experiential learning, Pharmaceutics enables students to gain the scientific foundation to understand drug physicochemical properties, practical aspects of dosage forms and drug delivery systems, and the biological applications of drug administration. 

Key Features

  • Chapter objectives and chapter summaries illustrate and reinforce key ideas
  • Designed to meet curricular guidelines for pharmaceutics and laboratory skills mandated by the Accreditation Council for Pharmacy Education (ACPE)
  • Companion website features resources for students and instructors, including videos illustrating difficult processes and procedures and practice questions and answers.  Instructor resources include Powerpoint slides and a full-color image bank


For students in pharmaceutical science programs taking pharmaceutics or biopharmaceutics courses at the undergraduate, graduate and doctoral level.

Table of Contents




List of Contributors

Part I: Physical Principles and Properties of Pharmaceutics

Chapter 1. Introduction: Terminology, Basic Mathematical Skills, and Calculations

1.1 Introduction

1.2 Review of Basic Mathematical Skills

1.3 Graphical Representation

1.4 Dimensions and Units

1.5 Conclusions

Case Studies


Chapter 2. Physical States and Thermodynamic Principles in Pharmaceutics

2.1 Introduction

2.2 Composition of Matter

2.3 Forces of Attraction and Repulsion

2.4 States of Matter

2.5 Thermodynamics

2.6 Basic Concepts and Definitions

2.7 The First Law of Thermodynamics

2.8 Enthalpy and Heat Capacity

2.9 The Second Law of Thermodynamics

2.10 The Third Law of Thermodynamics

2.11 Free Energy and Thermodynamic Functions

2.12 Chemical Equilibrium

2.13 Open Systems

2.14 Conclusions

Case Studies

Appendix 2.1 Calculus Review


Chapter 3. Physical Properties, Their Determination, and Importance in Pharmaceutics

3.1 Introduction

3.2 Surface and Interfacial Tension

3.3 Adsorption

3.4 Solubilization

3.5 Rheology

3.6 Colligative Properties

3.7 Osmolarity and Osmolality

3.8 Solubility and Solutions of Nonelectrolytes

3.9 Spectroscopy

3.10 Conclusions

Case Studies


Chapter 4. Equilibrium Processes in Pharmaceutics

4.1 Introduction

4.2 Gastrointestinal Physiology

4.3 Ionization

4.4 Partition Coefficient: Lipophilicity

4.5 Equilibrium Solubility

4.6 The Effect of pH

4.7 Use of Co-solvents

4.8 Drug Dissolution and Dissolution Process

4.9 Factors Influencing the Dissolution Rate

4.10 Passive Diffusi


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© Academic Press 2014
Academic Press
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About the Editor

Alekha Dash

Affiliations and Expertise

R.Ph, PhD, Professor and Chair, Department of Pharmacy Sciences, School of Pharmacy and Health Professions, Creighton University, Omaha, NE

Somnath Singh

Affiliations and Expertise

PhD, Associate Professor, Department of Pharmacy Sciences, School of Pharmacy & Health Professions, Creighton University, Omaha, NE

Justin Tolman

Affiliations and Expertise

PharmD, PhD, Assistant Professor, Department of Pharmacy Sciences, School of Pharmacy & Health Professions, Creighton University, Omaha, NE


"Pharmaceutics is an important part of the practice of pharmacy. This book outlines pharmaceutics and uses chapter summary questions and case studies to reinforce the concepts…This book is appropriate for pharmaceutical science, pharmacy, and biomedical sciences courses. It is written at a level that is easy to follow and provides practical examples. Compared to other pharmaceutics books…this one is up to date and student-friendly." Rating: 4, March 21, 2014