Phagocytosis—past and future

Phagocytosis—past and future

1st Edition - January 1, 1982

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  • Editor: Liana Bolis
  • eBook ISBN: 9780323144698

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Phagocytosis—Past and Future is a collection of contributions by investigators who met in the Province of Messina, Sicily, in October 1980 to discuss the functions of phagocytic leukocytes in the host-parasite relationship. The topics discussed are largely in the areas of cell biology, cellular immunology, and biochemistry. They ranged from aspects of cellular movement and the ingestion process per se, to definition of substances that affect the function of phagocytic leukocytes and the nature of cidal mechanisms at the molecular level. This volume is organized into six sections encompassing 33 chapters and begins with an overview of Ilya Ilich Metchnikoff's life as well as his scientific contributions, particularly in the area of bacteriology and his research on mesodermal amoeboid cells. The next chapters focus on the mechanism of phagocytosis, with reference to aspects of cell membrane, cell movement, and ingestion. The reader is methodically introduced to the biochemical aspects of phagocytosis, from molecular modulations to energetics, oxygen radicals, and enzymes. The discussion then shifts to macrophages, their function in antigen recognition, receptor-mediated endocytosis in macrophage cell hybrids, and the role of phagocytosis in macrophage activation. The remaining chapters examine the cidal mechanisms of phagocytic leukocytes and aspects of inflammation. This book will be of interest to scientists and researchers in fields such as biology, biochemistry, immunology, pathology, pharmacology, and physiology.

Table of Contents

  • Contributors


    1. Historical Introduction

    Metchnikoffs Life and Scientific Contributions in Historical Perspective

    2. Phagocytosis: Aspects of Cell Membrane, Cell Movement, and Ingestion Mechanism

    The Mechanism of Phagocytosis

    Electrophysiological Properties of Macrophages and Macrophage-Like Cells

    Early Consequences of Neutrophil Activation and Their Association with Degranulation

    Specific Receptors and Transmethylation Reactions Are Required for Leukocyte Chemotaxis

    Chemotactic Factors: Locomotory Hormones

    3. Some Biochemical Concomitants of Phagocytosis: Molecular Modulations, Energetics, Oxygen Radicals, Enzymes, and Their Cytological Locales Arachidonic Acid Metabolism in Leukocytes

    Arachidonic Acid Metabolism in HL60 Granulocytes

    Creatine Kinase and Its Isoenzymes in Leukocytes

    The Production of Superoxide by Neutrophils

    The Respiratory Burst in Phagocytic Leukocytes

    Super oxide-Producing Oxidases in Guinea Pig Neutrophils: Collaboration in the Respiratory Burst

    A Cytochemical Approach to the Function of Phagocytic Leukocytes

    4. Macrophages: Recognition, Receptors, and Aspects of "Activation"

    Macrophage Function in Antigen Recognition

    Phagocytosis—Modes of Particle Recognition and Stimulation by Natural Peptides

    Receptor-Mediated Endocytosis in Macrophage Cell Hybrids

    Remote Control of Macrophage Activation: Influence of a Nonspecific Inflammation

    A T Lymphocyte Hybridoma Which Generates MIF/MAF

    Role of Phagocytosis in Macrophage Activation

    A Role of Complement Proteins in the Stimulation of Human Mononuclear Phagocytes

    Constituents of Cell Surfaces That Regulate Activation of the Human Alternative Complement Pathway

    Hydrogen Peroxide Secretion by Macrophages as a Marker of Activation and a Mediator of Cytolysis: Role of Tumor Cell Antioxidant Defenses

    Biochemical Characteristics of Macrophages in Different Functional States

    5. Function: Cidal Mechanisms of Phagocytic Leukocytes Requirement of Membrane Stimulation for Intracellular Killing

    Lysosome Fusion Responses of Macrophages to Infection: Behavior and Significance

    Cidal Mechanisms and Their Dependence on Hydrogen Peroxide

    Oxidative Events Associated with Microbicidal Activity in Phagocytic Cells

    Role of Activated Macrophages in Resistance to Rickettsial Infections

    Macrophages as Mediators of Immunosuppression in African Trypanosomiasis

    6. Aspects of Inflammation

    Role of Neutrophil Lysosomal Granules in the Evolution of the Inflammatory Response

    Plasma Proteins and Cells in Inflammation

    Seastar Factor (SSF): Effects on Vertebrate Inflammation and Experimental Corneal Neovascularization

    Disease Processes in Seastars: A Metchnikovian Challenge


Product details

  • No. of pages: 608
  • Language: English
  • Copyright: © Academic Press 1982
  • Published: January 1, 1982
  • Imprint: Academic Press
  • eBook ISBN: 9780323144698

About the Editor

Liana Bolis

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