Phagocytosis—Past and Future is a collection of contributions by investigators who met in the Province of Messina, Sicily, in October 1980 to discuss the functions of phagocytic leukocytes in the host-parasite relationship. The topics discussed are largely in the areas of cell biology, cellular immunology, and biochemistry. They ranged from aspects of cellular movement and the ingestion process per se, to definition of substances that affect the function of phagocytic leukocytes and the nature of cidal mechanisms at the molecular level.
This volume is organized into six sections encompassing 33 chapters and begins with an overview of Ilya Ilich Metchnikoff's life as well as his scientific contributions, particularly in the area of bacteriology and his research on mesodermal amoeboid cells. The next chapters focus on the mechanism of phagocytosis, with reference to aspects of cell membrane, cell movement, and ingestion. The reader is methodically introduced to the biochemical aspects of phagocytosis, from molecular modulations to energetics, oxygen radicals, and enzymes. The discussion then shifts to macrophages, their function in antigen recognition, receptor-mediated endocytosis in macrophage cell hybrids, and the role of phagocytosis in macrophage activation. The remaining chapters examine the cidal mechanisms of phagocytic leukocytes and aspects of inflammation. This book will be of interest to scientists and researchers in fields such as biology, biochemistry, immunology, pathology, pharmacology, and physiology.
- Historical Introduction Metchnikoffs Life and Scientific Contributions in Historical Perspective
- Phagocytosis: Aspects of Cell Membrane, Cell Movement, and Ingestion Mechanism The Mechanism of Phagocytosis Electrophysiological Properties of Macrophages and Macrophage-Like Cells Early Consequences of Neutrophil Activation and Their Association with Degranulation Specific Receptors and Transmethylation Reactions Are Required for Leukocyte Chemotaxis Chemotactic Factors: Locomotory Hormones
- Some Biochemical Concomitants of Phagocytosis: Molecular Modulations, Energetics, Oxygen Radicals, Enzymes, and Their Cytological Locales Arachidonic Acid Metabolism in Leukocytes Arachidonic Acid Metabolism in HL60 Granulocytes Creatine Kinase and Its Isoenzymes in Leukocytes The Production of Superoxide by Neutrophils The Respiratory Burst in Phagocytic Leukocytes Super oxide-Producing Oxidases in Guinea Pig Neutrophils: Collaboration in the Respiratory Burst A Cytochemical Approach to the Function of Phagocytic Leukocytes
- Macrophages: Recognition, Receptors, and Aspects of "Activation" Macrophage Function in Antigen Recognition Phagocytosis—Modes of Particle Recognition and Stimulation by Natural Peptides Receptor-Mediated Endocytosis in Macrophage Cell Hybrids Remote Control of Macrophage Activation: Influence of a Nonspecific Inflammation A T Lymphocyte Hybridoma Which Generates MIF/MAF Role of Phagocytosis in Macrophage Activation A Role of Complement Proteins in the Stimulation of Human Mononuclear Phagocytes Constituents of Cell Surfaces That Regulate Activation of the Human Alternative Complement Pathway Hydrogen Peroxide Secretion by Macrophages as a Marker of Activation and a Mediator of Cytolysis: Role of Tumor Cell Antioxidant Defenses Biochemical Characteristics of Macrophages in Different Functional S
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- © Academic Press 1982
- 1st January 1982
- Academic Press
- eBook ISBN: