Description

Biotransformation of Pesticides is an updated, "one-stop" resource for academic, industry and regulatory scientists involved in research and regulatory activities related to pesticide biotransformation and human health.  This book provides an in depth look at how pesticides are biotransformed, which is essential to understanding exposure, dose, toxicity and health risks.  This essential reference contains the biotransformation of pesticides from uptake to excretion, including toxicokinetics and emphasizes metabolism in non-target species, including experimental animals and humans. 

Key Features

  • Includes four new chapters and expanded material on pesticide biotransformation and disposition, an active area of pesticide toxicology that is becoming increasingly important for human health risk assessment
  • Offers a practical and portable guide covering the most up-to-date research results on metabolic transformations of pesticides
  • Provides scientists and regulatory researchers with the information they need to conduct accurate risk assessments and make informed decisions on which exposures to study further in human populations

Readership

Toxicologists in the agrochemical industry, regulatory toxicologists, academic toxicologists, epidemiologists, chemists studying pesticide in food commodities

Table of Contents

Dedication from Hayes Handbook of Pesticide Toxicology Third Edition

Preface

Preface from Hayes Handbook of Pesticide Toxicology Third Edition

Contributing Authors

Chapter 1. Introduction to Pesticide Biotransformation and Disposition

Introduction

Relevance of Biotransformation and Disposition Studies

Chapter 2. Summary of Methods Used in the Study of Pesticide Biotransformation and Disposition

Introduction

Analytical Methods for Pesticides and Pesticide Metabolites

Uptake, Distribution, and Toxicokinetics

Cell Culture, Subcellular Fractions, and Recombinant Enzymes

Proteomics

Metabolomics

Summary

Chapter 3. Absorption

Introduction

Factors that Influence the Transfer and Availability of Chemicals in the Body

Absorption

Summary and Future Directions

Chapter 4. Introduction to Biotransformation (Metabolism)

Introduction

Reactions Catalyzed in Xenobiotic Metabolism

Xenobiotic-Metabolizing Enzymes

Phase I Xenobiotic-Metabolizing Enzymes

Phase II Xenobiotic-Metabolizing Enzymes

Summary and Conclusions

Chapter 5. Biotransformation (Metabolism) of Pesticides

Introduction

External Transformation

Biotransformation

Metabolism in Humans

Toxicity of Metabolites

Physiological Factors Affecting Biotransformation

Tolerance and Resistance

Conclusions

Chapter 6. Distribution and Pharmacokinetics Models

Introduction

Distribution

Pharmacokinetics

Conclusions

Chapter 7. Metabolic Interactions of Pesticides

Chemical Factors Affecting Pesticide Metabolism: Introduction

Induction

Inhibition

Biphasic Effects: Inhibition and Induction

Activation

Hepatotoxicity

Conclusions

Chapter 8. Pesticide Excretion

Introduction

Renal Function

Details

No. of pages:
234
Language:
English
Copyright:
© 2012
Published:
Imprint:
Academic Press
Print ISBN:
9780123854810
Electronic ISBN:
9780123854827