Personalized Psychiatry - 1st Edition - ISBN: 9780128131763

Personalized Psychiatry

1st Edition

Editors: Bernhard Baune
Paperback ISBN: 9780128131763
Imprint: Academic Press
Published Date: 15th October 2019
Page Count: 604
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Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders.

Key Features

  • Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics
  • Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry
  • Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective


Advanced students and researchers in neuroscience, psychiatry, psychology, medicine, and pharmacology

Table of Contents

Bernhard Theodor Baune

1. What is Personalized Psychiatry and why is it necessary?
Bernhard Theodor Baune

2. Longitudinal Trajectory Modelling Psychosis
Klaus Oliver Schubert, Scott Richard Clark and Bernhard Theodor Baune

3. Mood trajectories as a basis for Personalized Psychiatry in young people
Klaus Oliver Schubert

4. Transdiagnostic Early Intervention, Prevention and Prediction in Psychiatry
Patrick McGorry

5. Early Intervention, Prevention and Prediction in Mood Disorders
Ian Hickie

6. Consumer Participation in Personalized Psychiatry
Harris A. Eyre

7. Experimental validation of psychopathology in Personalized Psychiatry
Alfons Hamm

8. Deep Brain Stimulation for Major Depression - A Prototype of a Personalized Treatment in Psychiatry
Thomas Schlaepfer

9. The Psychiatric Genomics Consortium: history, development and future
Patrick Sullivan, Hunna Jones Watson and Zeynep Yilmaz

10. Statistical Genetic Concepts in Psychiatric Genomics
Divya Mehta

11. Opportunities and challenges of machine learning approaches to biomarker signature identification in Psychiatry
Emanuel Schwarz

12. Human iPSC-derived neurons for Personalized Psychiatry
Julio Licinio, Cedric Bardy and Seth W. Perry

13. Genetics of Alcohol Use Disorder
Falk W. Lohoff and Jill Sorcher

14. Genomics of Autism Spectrum Disorders
Owen Rennert

15. Genetic underpinnings of schizophrenia
Aiden Corvin

16. Genomics of Major Depressive Disorder
Douglas F. Levinson

17. Neurobiological markers predicting treatment response in anxiety disorders
Ulrike Lueken

18. Genomics of Bipolar Disorder
Olav B. Smeland, Andreas J. Forstner, Alexander Charney, Eli Stahl and Ole A. Andreassen

19. Genomics of Borderline Personality Disorder
Stephanie H. Witt, Fabian Streit and Lucia Colodro-Conde

20. Genetics of Obsessive-Compulsive Disorder
Christie L. Burton, Csaba Barta, Danielle Cath, Dan Geller, Odile A. van den Heuvel, Yin Yao, Valsamma Eapen, Edna Gruenblatt and Gwyneth Zai

21. Genetics and Pharmacogenetics of Attention Deficit Hyperactivity Disorder in Adults
Catia Scassellati

22. Genomics of Alzheimer’s Disease
Danielle Posthuma

23. Genetic contribution to Post-Traumatic Stress Disorders
Angela Junglen, Christina Sheerin, Doug Delahanty, Michael Hauser, Adriana Lori, Rajendra Morey, Caroline M. Nievergelt, Nicole Nugent, Jonathan Sebat, Alicia K Smith, Jennifer A. Sumner, Monica Uddin and Ananda B. Amstadter

24. Genomic contributions to anxiety disorders
Dan Joseph Stein

25. Biomarker discovery in the human proteome of psychosis
David Cotter, Sophie Sabherwal and Klaus Oliver Schubert

26. Molecular biomarkers in depression for Personalized Psychiatry
Anand Gururajan and John F. Cryan

27. Neurobiological predictors of late life depression and treatment response
Helmet Talib Karim, Charles F. Reynolds III and Stephen Smagula

28. Copy number variations (CNVs) in Major Psychiatric Disorders
Franziska Degenhardt

29. Gene-environmental interactions in Psychiatry
Hans-Juergen Grabe

30. Epigenetics: a new approach to understand mechanisms in depression and to predict antidepressant treatment response
Helge Frieling

31. Gene co-expression network and machine learning
Liliana Ciobanu

32. Pharmacogenomic of Bipolar Disorder
Claudia Pisanu, Alessio Squassina, Martin Alda and GIOVANNI SEVERINO

33. Pharmacogenomics of treatment response in Major Depressive Disorder
Joanna Biernacka

34. Genomic treatment response prediction in Schizophrenia
James Tynan Rhys Walters

35. Personalized treatment in Bipolar Disorder
Estela Salagre, E. Vieta and Iria Grande

36. The challenge of genetic testing in Psychiatry
Chad Bousman

37. Opportunities and challenges of implementation models of pharmacogenomics in clinical practice
Daniel J. Mueller

38. Metabolomics in Psychiatry
Roger S. McIntyre and Renee-Marie Ragguett

39. Real-time fMRI brain-computer interface: a tool for Personalized Psychiatry?
David E. Linden

40. How Functional Neuroimaging can be used for prediction and evaluation in Psychiatry
Catherine Harmer

41. Structural neuroimaging and imaging genetics for Personalized Psychiatry: developments and opportunities of the ENIGMA consortium
Lianne Schmaal

42. Applying a taxonomy of neural circuit types in depression and anxiety for Personalized Psychiatry
Leanne M. Williams

43. Multimodal Predictive Modelling in Psychiatry
Scott Richard Clark and Klaus Oliver Schubert

44. Standardised Biomarker and Biobanking requirements for Personalised Psychiatry
Catherine Toben, Victoria Kiriaki Arnet, Anita Jane Lo, Pamela Helen Saunders and Bernhard Theodor Baune

45. Ethical, Policy and Research Considerations for Personalized Psychiatry
Ryan Abbott, Harris A. Eyre and Donald Dao-Yuan Chang

46. The Future of Personalized Psychiatry
Bernhard Theodor Baune


No. of pages:
© Academic Press 2019
15th October 2019
Academic Press
Paperback ISBN:

About the Editor

Bernhard Baune

Prof. Bernhard Baune (PhD, MD, MPH, FRANZCP) is the Director of the University Hospital Department of Psychiatry and Psychotherapy, University of Münster, Germany. He also leads the newly established Laboratory Division of Molecular Neurobiology of Mental Health at the University. Prof. Baune has been the Cato Chair and Head of Department of Psychiatry at the University of Melbourne, Australia prior to being awarded the Director position at the University of Münster. Prof. Baune is a Fellow of the Royal Australian and New Zealand College of Psychiatrist (FRANZCP), he is a Professorial Fellow of the Department of Psychiatry, University of Melbourne and also at the Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia. Prof. Baune is known for his extensive research program into depression and cognitive dysfunction, personalised psychiatry, molecular psychiatry, prediction and biomarker research and treatment response research as well as for key research achievements in the field of immune-neurobiology of psychiatric disorders. Prof. Baune’s translational work at the University of Münster is designed to make real-world differences to the lives of people with mental illness by integrating neurobiological and clinical information, by personalising treatments and by targeting the mechanisms of functional recovery. Other related work include the leadership of an international consortium on the genomics of severe depression and response to ECT in affective disorders (GenECT-ic), leading an international study on the genomics of cognitive function in depression and directing the ECNP network on trans- diagnostic pharmacogenomics and transcriptomics in psychiatric disorders. His research is nationally and internationally recognised and he has published more than 500 peer-reviewed articles, reviews and book chapters, and he edited several text books in Psychiatry, and most recently the books “Personalised Psychiatry” (Elsevier), “Inflammation and Immunity of Depression” (Elsevier) and “Cognitive Dimensions of Major Depressive Disorder” (Oxford University Press).

Affiliations and Expertise

1. Department of Psychiatry and Psychotherapy, University of Münster, Münster, Germany 2. Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Parkville, VIC, Australia 3. The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia

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