Personalized Psychiatry

Personalized Psychiatry

1st Edition - October 15, 2019

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  • Editor: Bernhard Baune
  • Paperback ISBN: 9780128131763
  • eBook ISBN: 9780128131770

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Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders.

Key Features

  • Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics
  • Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry
  • Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective


Advanced students and researchers in neuroscience, psychiatry, psychology, medicine, and pharmacology

Table of Contents

  • Preface
    Bernhard Theodor Baune
    1. What is personalized psychiatry and why is it necessary?
    Bernhard Theodor Baune
    2. The modeling of trajectories in psychotic illness
    Scott R. Clark, Klaus Oliver Schubert, and Bernhard T. Baune
    3. Mood trajectories as a basis for personalized psychiatry in young people
    Klaus Oliver Schubert, Scott R. Clark, Linh K. Van, Jane L. Collinson, and Bernhard T. Baune
    4. Transdiagnostic early intervention, prevention, and prediction in psychiatry
    Cristina Mei, Barnaby Nelson, Jessica Hartmann, Rachael Spooner, and Patrick D. McGorry
    5. Early intervention, prevention, and prediction in mood disorders: Tracking multidimensional outcomes in young people presenting for mental health care
    Elizabeth M. Scott, Joanne S. Carpenter, Frank Iorfino, Shane P.M. Cross, Daniel F. Hermens, Django White, Rico S.Z. Lee, Sharon L. Naismith, Adam J. Guastella, Nicholas Glozier, F. Markus Leweke, Dagmar Koethe, Jim Lagopoulos, Jan Scott, Blake A. Hamilton, Jacob J. Crouse, Ashleigh M. Tickell, Alissa Nichles, Natalya Zmicerevska, Lillian J. Gehue, Manreena Kaur, Kate M. Chitty, and Ian B. Hickie
    6. Consumer participation in personalized psychiatry
    Harris A. Eyre, Elisabeth R.B. Becker, Marissa S. Blumenthal, Ajeet B. Singh, Cyrus Raji, Arshya Vahabzadeh, Zoe Wainer, and Chad Bousman
    7. Experimental validation of psychopathology in personalized psychiatry
    Alfons O. Hamm
    8. Deep brain stimulation for major depression: A prototype of a personalized treatment in psychiatry
    Thomas E. Schlaepfer and Bettina H. Bewernick
    9. The Psychiatric Genomics Consortium: History, development, and the future
    Hunna J. Watson, Zeynep Yilmaz and Patrick F. Sullivan
    10. Statistical genetic concepts in psychiatric genomics
    Darina Czamara and Divya Mehta
    11. Opportunities and challenges of machine learning approaches for biomarker signature identification in psychiatry
    Han Cao and Emanuel Schwarz
    12. Personalized psychiatry with human iPSCs and neuronal reprogramming
    Cedric Bardy, Zarina Greenberg, Seth W. Perry and Julio Licinio
    13. Genetics of alcohol use disorder
    Jill L. Sorcher and Falk W. Lohoff
    14. Genomics of autism spectrum disorders
    Margarita Raygada, Paul Grant and Owen M. Rennert
    15. Genomics of schizophrenia
    A. Corvin, C. Ormond and A.M. Cole
    16. Genomics of major depressive disorder
    Douglas F. Levinson
    17. Personalized mental health: Artificial intelligence technologies for treatment response prediction in anxiety disorders
    Ulrike Lueken and Tim Hahn
    18. The genetic architecture of bipolar disorder: Entering the road of discoveries
    Olav B. Smeland, Andreas J. Forstner, Alexander Charney, Eli A. Stahl and Ole A. Andreassen
    19. Genomics of borderline personality disorder
    Fabian Streit, Lucı´a Colodro-Conde, Alisha S.M. Hall and Stephanie H. Witt
    20. Genetics of obsessive-compulsive disorder and Tourette disorder
    Christie L. Burton, Csaba Barta, Danielle Cath, Daniel Geller, Odile A. van den Heuvel, Yin Yao, (Obsessive Compulsive Disorder and Tourette Syndrome Working Group of the Psychiatric Genomics Consortium), Valsamma Eapen, Edna Grünblatt and Gwyneth Zai
    21. Genetics and pharmacogenetics of attention deficit hyperactivity disorder in childhood and adulthood
    Cristian Bonvicini, Carlo Maj and Catia Scassellati
    22. Genomics of Alzheimer’s disease
    Margot P. van de Weijer, Iris E. Jansen, Anouk H.A. Verboven, Ole A. Andreassen and Danielle Posthuma
    23. Current progress and future direction in the genetics of PTSD: Focus on the development and contributions of the PGC-PTSD working group
    Angela G. Junglen, Christina Sheerin, Douglas L. Delahanty, Michael A. Hauser, Adriana Lori, Rajendra A. Morey, Caroline M. Nievergelt, Nicole R. Nugent, Jonathan Sebat, Alicia K. Smith, Jennifer A. Sumner, Monica Uddin and Ananda B. Amstadter
    24. Genomic contributions to anxiety disorders
    Shareefa Dalvie, Nastassja Koen and Dan J. Stein
    25. Proteomics for diagnostic and therapeutic blood biomarker discovery in schizophrenia and other psychotic disorders
    David R. Cotter, Sophie Sabherwal and Klaus Oliver Schubert
    26. Molecular biomarkers in depression: Toward personalized psychiatric treatment
    Anand Gururajan, John F Cryan and Timothy G Dinan
    27. Neuroimaging biomarkers of late-life major depressive disorder pathophysiology, pathogenesis, and treatment response
    Helmet T. Karim, Charles F. Reynolds, III and Stephen F. Smagula
    28. Copy number variants in psychiatric disorders
    Franziska Degenhardt
    29. Gene-environment interaction in psychiatry
    Hans Jörgen Grabe and Sandra Van der Auwera
    30. Epigenetics: A new approach to understanding mechanisms in depression and to predict antidepressant treatment response
    Helge Frieling, Stefan Bleich and Alexandra Neyazi
    31. Gene coexpression network and machine learning in personalized psychiatry
    Liliana G. Ciobanu, Micah Cearns and Bernhard T. Baune
    32. Pharmacogenomics of bipolar disorder
    Claudia Pisanu, Alessio Squassina, Martin Alda and Giovanni Severino
    33. Pharmacogenomics of treatment response in major depressive disorder
    Joanna M. Biernacka, Ahmed T. Ahmed, Balwinder Singh and Mark A. Frye
    34. Genomic treatment response prediction in schizophrenia
    Sophie E. Legge, Antonio F. Pardiñas and James T.R. Walters 
    35. Personalized treatment in bipolar disorder
    Estela Salagre, Eduard Vieta and Iria Grande
    36. Genetic testing in psychiatry: State of the evidence
    Chad A. Bousman, Lisa C. Brown, Ajeet B. Singh, Harris A. Eyre and Daniel J. Müller
    37. Opportunities and challenges of implementation models of pharmacogenomics in clinical practice
    Jonathan C.W. Liu, Ilona Gorbovskaya, Chad Bousman, Lisa C. Brown and Daniel J. Müller
    38. Metabolomics in psychiatry
    Renee-Marie Ragguett and Roger S. McIntyre
    39. Real-time fMRI brain-computer interface: A tool for personalized psychiatry?
    David E.J. Linden
    40. How functional neuroimaging can be used for prediction and evaluation in psychiatry
    Beata R. Godlewska and Catherine J. Harmer
    41. Neuroimaging, genetics, and personalized psychiatry: Developments and opportunities from the ENIGMA consortium
    Lianne Schmaal, Christopher R.K. Ching, Agnes B. McMahon, Neda Jahanshad and Paul M. Thompson
    42. Applying a neural circuit taxonomy in depression and anxiety for personalized psychiatry
    Leanne M. Williams and Andrea N. Goldstein-Piekarski
    43. Multimodal modeling for personalized psychiatry
    Scott R. Clark, Micah Cearns, Klaus Oliver Schubert and Bernhard T. Baune
    44. Standardized biomarker and biobanking requirements for personalized psychiatry
    Catherine Toben, Victoria K. Arnet, Anita Lo, Pamela H. Saunders and Bernhard T. Baune
    45. Ethical, policy, and research considerations for personalized psychiatry
    Ryan Abbott, Donald D. Chang and Harris A. Eyre
    46. The future of personalized psychiatry
    Bernhard T. Baune

Product details

  • No. of pages: 604
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: October 15, 2019
  • Imprint: Academic Press
  • Paperback ISBN: 9780128131763
  • eBook ISBN: 9780128131770

About the Editor

Bernhard Baune

Prof. Bernhard Baune (PhD, MD, MPH, FRANZCP) is the Director of the University Hospital Department of Psychiatry and Psychotherapy, University of Münster, Germany. He also leads the newly established Laboratory Division of Molecular Neurobiology of Mental Health at the University. Prof. Baune has been the Cato Chair and Head of Department of Psychiatry at the University of Melbourne, Australia prior to being awarded the Director position at the University of Münster. Prof. Baune is a Fellow of the Royal Australian and New Zealand College of Psychiatrist (FRANZCP), he is a Professorial Fellow of the Department of Psychiatry, University of Melbourne and also at the Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Australia. Prof. Baune is known for his extensive research program into depression and cognitive dysfunction, personalised psychiatry, molecular psychiatry, prediction and biomarker research and treatment response research as well as for key research achievements in the field of immune-neurobiology of psychiatric disorders. Prof. Baune’s translational work at the University of Münster is designed to make real-world differences to the lives of people with mental illness by integrating neurobiological and clinical information, by personalising treatments and by targeting the mechanisms of functional recovery. Other related work include the leadership of an international consortium on the genomics of severe depression and response to ECT in affective disorders (GenECT-ic), leading an international study on the genomics of cognitive function in depression and directing the ECNP network on trans- diagnostic pharmacogenomics and transcriptomics in psychiatric disorders. His research is nationally and internationally recognised and he has published more than 500 peer-reviewed articles, reviews and book chapters, and he edited several text books in Psychiatry, and most recently the books “Personalised Psychiatry” (Elsevier), “Inflammation and Immunity of Depression” (Elsevier) and “Cognitive Dimensions of Major Depressive Disorder” (Oxford University Press).

Affiliations and Expertise

1. Department of Psychiatry and Psychotherapy, University of Münster, Münster, Germany 2. Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Parkville, VIC, Australia 3. The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia

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