Description

Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy.

The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics.

Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.

Key Features

  • Discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures
  • Details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the consequent diagnostic, prognostic and therapeutic potential of the field
  • Reviews the impact of the environment on epigenetic variations among individuals and the roles of pharmacology and drug development
  • Devotes several chapters to the advances made in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management

Readership

Advanced undergraduate students, graduate students, health care professionals, university researchers, and pharmaceutical and biotechnology companies interested in drug development. This book could also serve as a core textbook for advanced university or professional school courses with a focus on genetic and/or human diseases

Table of Contents

  • Preface
  • Section I. Overview
    • Chapter 1. Epigenetics of Personalized Medicine
      • 1. Introduction
      • 2. Epigenetic Variations among Individuals
      • 3. Bioinformatics of Personalized Epigenetics
      • 4. Diagnostic and Prognostic Epigenetic Approaches to Personalized Medicine
      • 5. Environmental Personalized Epigenetics
      • 6. Pharmacology and Drug Development of Personalized Epigenetics
      • 7. Personalized Epigenetics of Disorders and Disease Management
      • 8. Challenges and Future Directions
      • 9. Conclusion
  • Section II. Epigeneticvariations Among Individuals
    • Chapter 2. Interindividual Variability of DNA Methylation
      • 1. Introduction
      • 2. Biochemical Pathways Regulating DNA Methylation
      • 3. Challenges in Studying DNA Methylation
      • 4. Classification of Epigenotypes
      • 5. Early Evidence of Interindividual Variation in DNA Methylation from DNA Methylation Mutants
      • 6. Studies of Natural Variation in DNA Methylation—Model Systems
      • 7. Studies of Natural Variation in DNA Methylation—Humans
      • 8. Twin Studies
      • 9. Methylation Quantitative Trait Loci and Epigenetic Quantitative Trait Loci Studies
      • 10. Impact of Variation in DNA Methylation on Personalized Medicine
      • 11. Conclusion
      • List of Acronyms and Abbreviations
    • Chapter 3. Differences in Histone Modifications Between Individuals
      • 1. Introduction
      • 2. Chromatin Structure and Histone Modifications
      • 3. An Analytical Toolbox for Chromatin Structure and Histone Modifications
      • 4. The Discovery of cis-Regulatory Mutations
      • 5. An Abundance of cis-Regulatory Mutations
      • 6. Cis-Regulatory Mutations Influence Chromatin Structure, Histone Modifications, and Transcriptional Output
      • 7. Cis-Regulatory Mutations Can Act in a Cell-Type-Dependent Manne

Details

No. of pages:
610
Language:
English
Copyright:
© 2015
Published:
Imprint:
Academic Press
Electronic ISBN:
9780128004364
Print ISBN:
9780124201354

About the editor

Trygve Tollefsbol

Professor of Biology, University of Alabama at Birmingham, Birmingham, AL. Dr. Tollefsbol is a Professor of Biology and a Senior Scientist in the Center for Aging, Comprehensive Cancer Center, Nutrition Obesity Research Center, and the Comprehensive Diabetes Center at the University of Alabama at Birmingham (UAB). He is Director of the UAB Cell Senescence Culture Facility which he established in 1999 and a Steering Committee Member of the UAB Center for Aging. Dr. Tollefsbol trained as a Postdoctoral Fellow and Assistant Research Professor with members of the National Academy of Science at Duke University and the University of North Carolina. He earned doctorates in molecular biology and osteopathic medicine from the University of North Texas Health Sciences Center and his bachelor’s degree in Biology from the University of Houston. He has received prior funding from the NIA, NCI, NHLBI, NIMH and other federal institutes as well as the Glenn Foundation for Medical Research, Susan G. Komen for the Cure, the American Federation for Aging Research (AFAR), and the American Institute for Cancer Research (AICR) among many other sources. The Glenn Foundation for Medical Research funding was unsolicited and was awarded to Dr. Tollefsbol for lifetime contributions to the field of aging. In 2006 Dr. Tollefsbol was selected and highlighted as part of the 25th anniversary of the AFAR for significant contributions to aging research. Dr. Tollefsbol’s research interests have covered a wide range of topics such as aging, epigenetics, nutrition, cancer, telomerase, and caloric restriction. Work from his laboratory has been featured in Women’s Health magazine, Shape magazine, and the AICR Newsletter and Dr. Tollefsbol has been a Scientist in the Spotlight in ScienceNow. Currently he serves as an Associate Editor for Frontiers in Epigenomics and is on the Editorial Boards of the international journals Open Longevity Science, Epigenetics of Diabetes and Obesity, Molecular Biot