Description

Disorders of the peripheral nervous system (PNS) are the cause of prominent neurological symptoms including weakness, sensory loss, pain and autonomic dysfunction associated with deficits, morbidity and mortality. These disorders may be primary hereditary or cryptogenic neurologic disorders confined to the PNS or part of the pathology of both the central nervous system and the PNS. Most PNS disorders are secondary to other system disorders and may be responsive to treatment of the primary disease. Important advances have been obtained in several areas including molecular genetics, biochemistry, immunology, morphology and physiology that have enhanced our understanding of the causes and consequences of damage to peripheral nerve. Understanding of both these groups of PNS diseases has greatly expanded over recent years and has led to important advances of treatment both to protect and to repair damages of peripheral nerve. This volume provides an overview of the state-of-the-art of examination, diagnosis and treatment of these very diverse disorders and will be of interest to both the research and clinical neuroscience and neurology communities.

Key Features

  • Covers both hereditary and cryptogenic neurologic disorders
  • Includes advances in the basic science of PNS from molecular genetics, biochemistry, immunology, morphology and physiology
  • Detailed coverage of neuropathy in connective tissue disorders, infectious disorders, metabolic disorders and malignancy

Readership

Clinical neurologists and research neuroscientists

Table of Contents

Handbook of Clinical Neurology 3rd Series

Foreword

Preface

Contributors

Section 1: Introduction

Chapter 1. Prelude to the peripheral neuropathies

Section 2: Structure and function

Chapter 2. Microscopic anatomy: normal structure

The nerve trunk

Development

Aging

Conclusions

References

Chapter 3. Gross anatomy and development of the peripheral nervous system

Introduction

Gross anatomy

Development of the PNS

Conclusion

References

Chapter 4. Physiology and pathophysiology of myelinated nerve fibers

Introduction

Axonal structure and function

Fluctuations in excitability with impulse transmission

Assessment of nerve excitability in a clinical setting

Mechanisms of conduction block

Impulse conduction in demyelinating neuropathies

Multifocal motor neuropathy, axonal hyperpolarization, and conduction block

Conclusions

References

Chapter 5. Biology of Schwann cells

Introduction

Schwann cell development and differentiation

Biology of Schwann cell myelination

Nonmyelinating (remak) Schwann cells

Schwann cells in wallerian degeneration and regeneration

Conclusions and perspectives

References

Chapter 6. Neurophysiological approach to disorders of peripheral nerve

Introduction

Pathological changes in peripheral nerve disorders

Electromyography (EMG)

Nerve conduction studies

Special studies

Relation between clinical manifestations and neurophysiological findings

Differential diagnosis of the patient with peripheral nerve disorders

Mononeuropathies/multiple mononeuropathies

Polyneuropathies with axonal loss and an acute/subacute onset (subtype 3A)

Polyneuropathies with axonal loss and slow onset (subtype 3B)

Details

No. of pages:
1008
Language:
English
Copyright:
© 2013
Published:
Imprint:
Elsevier
Print ISBN:
9780444529022
Electronic ISBN:
9780444633552