Peripheral Dopaminergic Receptors

1st Edition

Proceedings of the Satellite Symposium of the 7th International Congress of Pharmacology, Strasbourg, 24-25 July 1978

Editors: Jean Louis Jean Schwartz
Hardcover ISBN: 9780080231891
eBook ISBN: 9781483156163
Imprint: Pergamon
Published Date: 26th June 1979
Page Count: 420
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Peripheral Dopaminergic Receptors contains the proceedings of the Satellite Symposium of the 7th International Congress of Pharmacology held in Strasbourg, France, on July 24-25, 1978. The papers explore advances that have been made in understanding peripheral dopaminergic receptors and cover topics organized around five themes: dopamine measurement; structure-activity relationships; peripheral actions of dopamine; effects of dopamine on the kidney; and the physiological role of dopamine in the autonomic nervous system. This volume is comprised of 36 chapters and opens with a discussion on the dopamine vascular receptor, along with its agonists and antagonists. The reader is then introduced to the physiological and clinical implications of free and conjugated dopamine; dopamine-sensitive adenylate cyclase in the renal artery of dogs; dopamine-induced relaxation of isolated dog arteries; and concentration and function of dopamine in normal and diseased blood vessels. The following chapters explore the possible involvement of endogenous substances in the cardiovascular actions of dopamine; the role of dopamine receptors as mediators of the neurogenic vasodilatation by dopaminergic agents; and implications of renal and adrenal dopamine for the role of conjugated dopamine. Studies on the peripheral cardiovascular activity of dopamine in the rat are also presented. This book will be of interest to practitioners in biosciences, pharmacology, physiology, and medicine.

Table of Contents

Preface Introductory Lecture The Dopamine Vascular Receptor: Agonists and Antagonists Dopamine Measurement Free and Conjugated Dopamine: Physiological and Clinical Implications Tissue Dopamine Levels as an Indicator of Tyrosine Hydroxylase Activity A Mass Fragmentographic Assay of Human Plasma Catecholamines Histochemical and Biochemical Estimations of Dopamine in Postganglionic Autonomic Nerves Discussion Structure — Activity Relationship Structure-Activity and Conformational Requirements for Dopaminergic Agonists: Comparison of Central and Peripheral Dopamine Receptors Structure-Activity Relationships at Dopaminergic Receptors Dopamine Congeners derived from the Benzo(f)-Quinoline Ring Dopamine 3-0-Sulfate, a Direct Precursor of Free Norepinephrine: an Alternative Biosynthetic Pathway Dopamine-Sensitive Adenylate Cyclase in Canine Renal Artery Discussion Peripheral Actions of Dopamine (except Kidney) Dopamine and Chronic Auriculo-Ventricular Heart-Block in the Unanaesthetized Dog Discussion α-and ß-adrenoceptors, But Not Dopaminergic Receptors are Involved in the Positive Inotropic Action of Dopamine in the Rabbit Heart Discussion Dopamine-induced Relaxation of Isolated Dog Arteries In Vitro Study with Semi-rigid Rotameric Conformational Analogs of Dopamine Effects of Several Central Dopamine Receptor Stimulants on Mesenteric Arterial Blood Flow in Anesthetized Dogs Vasodilatation produced by Apomorphine in the Hindleg of the Dog Discussion Dopaminergic Receptors in the Coronary Arteries Concentration and Function of Dopamine in Normal and Diseased Blood Vessels Possible Involvement of Endogenous Substances in the Cardiovascular Actions of Dopamine Discussion Species Differences of Dopaminergic Vasodilation in the Intestine Search for a Serotoninergic Mechanism in the Pharmacological Effects of Dopami


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About the Editor

Jean Louis

Jean Schwartz