Perioperative Neuroscience

Translational Research

1st Edition - February 25, 2022
Editors: Hemanshu Prabhakar, Charu Mahajan, Indu Kapoor
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 0 0 3 - 3
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 0 0 4 - 0

Perioperative Neurosciences: Translational Research examines current clinical research focused on complications and the improvement of patient outcomes in neuroanesthesia and neuro… Read more

Purchase options

LIMITED OFFER

Save 50% on book bundles

Immediately download your ebook while waiting for your print delivery. No promo code is needed.

Institutional subscription on ScienceDirect

Request a sales quote

Perioperative Neurosciences: Translational Research examines current clinical research focused on complications and the improvement of patient outcomes in neuroanesthesia and neurocritical care. The book addresses important translational topics including neuroanesthetics, pharmacogenomics, neuroprotection and neurotoxicity. In addition, it covers special considerations for topics such as stroke, traumatic brain injury and pain, as well as for specific patient populations like geriatric and pediatric.

Cover image
Title page
Table of Contents
Copyright
Dedication
List of contributors
Foreword
Acknowledgment
1. Introduction
Abstract
Translational research and neurosciences
References
2. Basic principles of translational research
Abstract
Introduction to translational research
What is translational research?
History of translational research
Current concepts and domains
Ethics and regulations
Education and careers
Conclusions
References
3. Anesthetics and translational research
Abstract
Introduction
Induction and emergence from anesthesia processes
Anesthetics and consciousness: the “awareness” paradox
General anesthetics and neurodegenerative processes
Impact on carcinogenic processes
Perspectives
Conclusion
References
4. Neurotoxicity and translational research
Abstract
Introduction
Preclinical evidence and the use of animal models
Anesthesia and neurotoxicity: mechanisms
From laboratory to clinical trials: evidence in humans
Exposure to anesthesia and the elderly
Neuroprotective strategies in the perioperative setting
Anesthesia and neurotoxicity: future experimental modalities
Conclusions
References
5. Neuromonitoring and translational research
Abstract
Introduction
Clinical monitoring
For aneurysmal subarachnoid hemorrhage patients
For ischemic stroke patients
Imaging studies
Intracranial pressure and derived indices
Parenchymal microtransducer devices
Optic nerve sheath diameter
Transcranial Doppler
Pupillometry
Jugular venous oxygen saturation
Brain tissue oxygen partial pressure
Near infrared spectroscopy
Electroencephalography
Evoked potentials
Conclusion
References
6. Cognition and translational research
Abstract
Introduction
Cognitive dysfunctions in the perioperative period: definition and diagnosis
Animal models of cognitive dysfunction in perioperative neuroscience
Anesthetics
Clinical studies investigating cognitive dysfunction in perioperative neuroscience
Perioperative care for patients with known presurgery cognition dysfunctions
Limits of translational research for inconsistencies of evidence from preclinical studies
Conclusion
References
7. Geriatrics and translational research
Abstract
Cellular, biochemical, and molecular biology of aging
Physiology, immunology, and endocrinology of aging
Mechanisms and intervention of cellular senescence and stem cell aging
Computational and functional genomics of aging
Animal models of aging research
Geroprotectors as antiaging chemicals
Human experiments on longevity
Conclusion
References
8. Pediatrics and translational research
Abstract
Introduction
Preclinical research on perioperative anesthetics neurotoxicity
Clinical research on perioperative anesthetics neurotoxicity in children
Reasons for discrepancy between preclinical and clinical data
Conclusion
References
9. Stroke and translational research
Abstract
Animal models for ischemic stroke
Model for stroke risk factors
Neuronal protection
Free radical scavengers
Delayed neuronal injury
Inflammation
Regeneration in stroke and neuronal repair
Growth promoters
Other drugs
Conclusion
References
10. Traumatic brain injury and translational research: pharmacological and nonpharmacological perspectives
Abstract
Introduction
The question/controversy
Consensus statement
Conclusion
Conflict of interest
Authors’ contribution
References
11. Movement disorders and translational research
Abstract
Etiology, diagnosis, and monitoring
Conclusion
References
12. Epilepsy and translational research
Abstract
Introduction
Diagnostic evaluation
Treatment
Future perspective of translational research
References
13. Translational research in delayed cerebral ischemia
Abstract
Introduction
Experimental aneurysmal subarachnoid hemorrhage
Characteristics of experimental SAH models
Perspectives on the current status of SAH animal models
Failure in current SAH studies
Delayed brain injury
Delayed cerebral vasospasm: from extravascular blood to vessel lumen
Microcirculatory spasm and dysfunction
Microthrombosis: an additional explanation for DCI
Cortical spreading ischemia
Are we close to solving the mystery of SAH?
Future directions
Conclusion
References
14. Translation research in pain medicine
Abstract
Translational research
Types of pain
Models in pain management
Current trends in care
Immense opportunity for translational research in pain medicine
References
15. Ethical considerations in translational research
Abstract
Introduction
Evolution of translational research ethics
Ethical considerations in translational research
Ethical issues in vulnerable neurological population
References
Index

Hemanshu Prabhakar

Hemanshu Prabhakar, MBBS, MD, PhD is currently working as a Professor in the Department of Neuroanaesthesiology and Critical Care at the All India Institute of Medical Sciences, New Delhi. Dr. Prabhakar, having a research experience spanning over 20 years, is a member of various National and International societies. His extensive research in the field of neuroanaesthesia and critical care has been published in various national and international journals across the globe. Dr. Prabhakar is an eminent author and has various book titles to his name. He was featured in the Limca Book of Records 2019 for publishing several books on a niche subject.

Affiliations and expertise

Department of Neuroanaesthesiology and Critical Care, Neurosciences Center, AIIMS, New Delhi, India

Charu Mahajan

Charu Mahajan, MBBS, MD, DM is currently working as an Additional Professor in the Department of Neuroanaesthesiology and Critical Care at All India Institute of Medical Sciences, New Delhi. She has research experience of over a decade backing her profile and has been awarded with the prestigious NBM Gold medal in the subject of surgery in the year 2003. She has more than 50 publications to her name in the form of books and journal alike. She is also the reviewer of various prestigious national journals like the Neurology India and Indian Journal of Anaesthesia and is the member of various scientific bodies such as the SNACC, ISNACC and ISA.

Affiliations and expertise

Department of Neuroanaesthesiology and Critical Care, Neurosciences Center, AIIMS, New Delhi, India

Indu Kapoor

Indu Kapoor, MBBS, MD from the prestigious institute Lady Hardinge Medical College [LHMC] and MD from UCMS Delhi is currently serving as an Additional Professor in the department of Neuroanaesthesiology and Critical Care at All India Institute of Medical Sciences, New Delhi. She has more than 80 research papers published in national and international journals across the globe and numerous chapter contributions in reputed titles. She has also been awarded with the reputed Dr. TN. JHA Memorial Award by the Indian Society of Anaesthesiologists and Smt. Chandra and Sh. Narayan Wadhwani Memorial Award.

Affiliations and expertise

Department of Neuroanaesthesiology and Critical Care, Neurosciences Center, AIIMS, New Delhi, India