Perinatal and Developmental Epigenetics

Perinatal and Developmental Epigenetics

1st Edition - May 1, 2022
This is the Latest Edition
  • Editor: Garima Singh
  • Paperback ISBN: 9780128217856

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Description

Perinatal and Developmental Epigenetics, Volume 32, a new volume in the Translational Epigenetics series, provides a thorough overview of epigenetics in the early developmental and perinatal stages, illuminating pathways for drug discovery and clinical advances. Here, over 25 international researchers examine recent steps forward in our understanding of epigenetic programming during perinatal and early development. The book opens with an in-depth introduction to known and newly discovered epigenetic marks and how they regulate various cellular processes. Later sections examine various prenatal and perinatal environmental experiences and their ability to derail the normal developmental trajectory via epigenetic reprogramming. Insights and suggestions for future research illuminate approaches for identifying individual disease susceptibility. Concluding chapters highlight preventative and targeted therapeutic pathways to improve quality of life into adulthood.

Key Features

  • Examines disease onset stemming from epigenetic changes during the perinatal periods
  • Features contributions from international experts in the field, including basic biology, disease research and drug discovery
  • Offers intervention strategies to mitigate adverse developmental programming to improve health outcomes

Readership

Human geneticists, human genomicists, translational researchers in genomic medicine, epigenetics, reproductive biology, endocrinology, molecular biology, and developmental biology

Table of Contents

  • Section I: The ever-growing complexity of epigenetic regulation of gene expression
    1. Epigenetic regulation of gene expression: An overview of classical and recently discovered novel players: -Role of DNA methylation, Role of Histone modifications, Role of non-coding RNAs
    2. Epigenetic regulation of transposable elements and their impact on developmental processes
    3. Epigenetic regulation of germ cells
    4. Epigenetic regulation of cis-regulatory elements and transcription factors during development
    5. Genomic imprinting and developmental physiology: Intrauterine growth and postnatal period
    6. Metabolic regulation of epigenetic processes
    7. Role of RNA epigenetics in development

    Section II: Epigenetic programming of the placenta regulates short-term and long-term health outcomes
    8. Epigenetic regulation of placental function
    9. Role of placenta in developmental programming of sex-specific adult outcomes
    10. Epigenetic changes induced by Assisted Reproductive Technologies (ART) in the placenta and its effect on developmental outcomes

    Section III: Epigenetics, hormones, sex and developmental programming
    11. Epigenetic and hormone interaction and effect on gene regulation during prenatal and early postnatal life
    12. Role of epigenetics in shaping the sex difference in immune function during development
    13. Role of epigenetics in shaping sex differences in brain development and behavior
    14. Role of epigenetics in shaping sex differences in heart development and later life cardiovascular disease risk

    Section IV: Epigenetic programming by adverse perinatal influences
    15. Early life endocrine disruptors exposure and epigenetic programming
    16. Early life stress exposure and epigenetic programming
    17. Early life nutrition and epigenetic programming
    18. Early life air pollution exposure and epigenetic programming
    19. Early life substance abuse and epigenetic programming

    Section V: Advancing translational epigenetic research
    21. Modelling early life adversity in the laboratory –: Animal models, their advantages and challenges in extrapolating findings from animal studies to humans
    22. Clinical evidence of developmental programming due to early life exposures and long-term effects: Implications for public health
    23. Phenotypic plasticity: Adaptive vs Maladaptive response and epigenetic changes
    24. Epigenomics: A road to genome-wide characterization of epigenetic changes during development and identifying future individuals at risk of disease susceptibility

    Section VI: Pharmacological and non-pharmacological approaches to reprogram the developmental programming to improve the health outcomes
    26. Epigenetic signatures as biomarkers of early life experiences
    27. Environmental enrichment and its effect on modifying the epigenetic changes induced by early life adversity
    28. Dietary targeting of epigenome and its effect on early life adverse influences
    29. Early postnatal maternal care and epigenetic programming of HPA axis activity
    30. Emerging field of epigenetic editing: Implication for translational purposes for diseases with developmental origin and sex bias

Product details

  • No. of pages: 432
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: May 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780128217856
  • About the Editor

    Garima Singh

    Dr. Garima Singh is a Senior Research Instructor in the Department of Pathology, Anatomy & Cell Biology at Thomas Jefferson University in Philadelphia, Pennsylvania, USA. She has held research fellowships at the National Institute of Immunology (NII), India, the National Cancer Institute (NCI) at the National Institutes of Health (NIH), Bethesda, MD, and Thomas Jefferson University. Dr Singh has published in such peer reviewed journals as Frontiers in Genetics, Biochimica et Biophysica Acta - Molecular Basis of Disease, Frontiers in Integrative Neuroscience, and Toxicology Letters. Additionally, she serves on the editorial board of the Journal of Proteomics and Genomics.

    Affiliations and Expertise

    Senior Research Instructor, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA