Synthesis, Structures, and Applications

1st Edition - October 19, 1995

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  • Editor: Bernd Gutte
  • eBook ISBN: 9780080538594
  • Hardcover ISBN: 9780123109200

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In recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology. Active research programs worldwide are now engaged in developing peptide-based drugs and vaccines using modification of natural peptides and proteins, design of artificial peptides and peptide mimetics, and screening of peptide and phage libraries. In this comprehensive book, the authors discuss peptide synthesis and application within the context of their increasing importance to the pharmaceutical industry. Peptides: Synthesis, Structures, and Applications explores the broad growth of information in modern peptide synthetic methods and the structure-activity relationships of synthetic polypeptides.

Key Features

  • The history of peptide chemistry
  • Amide formation, deprotection, and disulfide formation in peptide synthesis
  • Solid-phase peptide synthesis
  • a-helix formation by peptides in water
  • Stability and dynamics of peptide conformation
  • An overview of structure-function studies of peptide hormones
  • Neuropeptides:peptide and nonpeptide analogs
  • Reversible inhibitors of serine proteinases
  • Design of polypeptides
  • Current capabilities and future possibilities of soluble chemical combinatorial libraries
  • Epitope mapping with peptides
  • Synthesis and applications of branched peptides in immunological methods and vaccines

Table of Contents

  • The History of Peptide Chemistry
    Amide Formation, Deprotection, And Disulfide Formation in Peptide Synthesis
    Solid Phase Peptide Synthesis
    A-Helix Formation By Peptides in Water
    Peptide Conformation: Stability and Dynamics
    Structure-Function Studies of Peptide Hormones: An Overview
    Neuropeptides: Peptides and Nonpeptide Analogs
    Reversible Inhibitors of Serine Proteinases, Naturallly Occurring Miniproteins, Semisynthetic Variants, Recombinant Homologues and Synthetic Peptides
    Design of Polypeptides
    Chemical Combinatorial Libraries: Current Capabilities and Future Possibilities
    Epitope Mapping with Peptides
    Active Immunization Using Synthetic Peptides

Product details

  • No. of pages: 511
  • Language: English
  • Copyright: © Academic Press 1995
  • Published: October 19, 1995
  • Imprint: Academic Press
  • eBook ISBN: 9780080538594
  • Hardcover ISBN: 9780123109200

About the Editor

Bernd Gutte

Affiliations and Expertise

Biochemisches Institut der Universitat urich, Zurich, Switzerland

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