During the last few years, the pace of research in the field of neuropeptide receptors has increased steadily: new neuropeptides were discovered, and the classification of receptor subtypes has been refined. It thus appeared essential to update the information. Peptide Receptors Part I summarizes current knowledge on ten distinct peptide families.
This volume integrates photomontages and maps of quantitative receptor autoradiography, in situ hybridization histochemistry, and immunocytochemistry images. Application of these classical techniques and of new approaches such as transgenic and knock-out animals has revealed a distinct species and tissue specific variation in receptor subtypes expression and pharmacology in the mammalian central nervous system.
The functional role of neuropeptides and their receptors in the CNS has been investigated thanks to the development of potent and selective receptor antagonists and agonists. The development of specific neuropeptide-related molecules will help to get a better understanding of receptor subtype physiology and neuronal distribution and may lead to innovative treatments in a variety of brain disorders.
- No. of pages:
- © Elsevier Science 2000
- 8th June 2000
- Elsevier Science
- eBook ISBN:
- Hardcover ISBN:
@from:(B.Z. Roitberg, University of Illinois at Chicago College of Medicine) @qu:This is an optimal way for a newcomer to the field to learn the subject and a good reference for any neuroscientist. I have no hesitation recommending it in the highest terms. @source:Doody's
Department of Physiological Sciences, Wallenberg Neuroscience Center, Biomedical Center A11, S-22184 Lund, Sweden
Department of Neuroscience, Retzius Laboratory B3:4, Karolinska Institutet, Retzius väg 8, S-17177 Stockholm, Sweden
IRISA/INRIAA, Rennes, France