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Peptide-Lipid Interactions - 1st Edition - ISBN: 9780121533526, 9780080490960

Peptide-Lipid Interactions, Volume 52

1st Edition

Editors: Sidney Simon Thomas McIntosh
eBook ISBN: 9780080490960
eBook ISBN: 9780080925851
Imprint: Academic Press
Published Date: 14th March 2002
Page Count: 601


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Table of Contents

PART I: Biophysical Techniques for Analyzing Peptide-Lipid Interactions Peptide-Membrane Interactions Determined Using Site Directed Spin Labeling. Isothermal Titration Calorimetry to Study Interactions Between Peptides and Lipid Membranes. Infrared Reflection-Absorption Spectroscopy of Lipids, Peptides, and Proteins in Aqueous Monolayers. Measuring the Depth of Amino Acid Residues in Membrane-Inserted Peptides by Fluorescence Quenching. Surface-sensitive X-ray and Neutron Scattering Characterization of Planar Lipid Model membranes and Lipid/Peptide Interactions. Lipid-Peptide Interactions Investigated by NMR. Peptide-Lipid Interactions in Supported Monolayers and Bilayers.

Part II: Theoretical and Computational Analyses of Peptide-Lipid Interactions Free Energy Determinants of Peptide Association with Lipid Bilayers. Investigating Ion Channels Using Computational Methods.

Part III: Experimental Investigations of Peptide-Lipid Interactions The Role of Electrostatic and Nonpolar Interactions in the Association of Peripheral Proteins with Membranes. The Energetics of Peptide-Lipid Interactions: Modulation by Interfacial Dipoles and Cholesterol. Transmembrane Alpha Helices. Lipidated Peptides as Tools to Understand the Membrane Interactions of Lipid-modified Proteins. Experimental and Computational Studies of the Interactions of Amphipathic Peptides with Lipid Surfaces. Interactions of pH-Sensitive Peptides and Polymers with Lipid Bilayers: Binding and Membrane Stability. The Hydrophobicity Threshold for Peptide Insertion into Membranes.

Part IV: Specialized Topics of Biological Relevance Signal Sequence Function in the Mammalian Endoplasmic Reticulum: A Biological Perspective. The Process of Membrane Fusion: Nipples, Hemifusion Pores, and Pore Growth. Prenylation of CaaX-Type Proteins: Basic Principles through Clinical Applications. Peptides as Probes of Protein-Protein Interactions Involved in Neurotransmitter Release.


This volume contains a comprehensive overview of peptide-lipid interactions by leading researchers. The first part covers theoretical concepts, experimental considerations, and thermodynamics. The second part presents new results obtained through site-directed EPR, electron microscopy, NMR, isothermal calorimetry, and fluorescence quenching. The final part covers problems of biological interest, including signal transduction, membrane transport, fusion, and adhesion.

Key Features

@introbul:Key Features @bul:* world-renowned experts

  • state-of-the-art experimental methods
  • monolayers, bilayers, biological membranes
  • theoretical aspects and computer simulations
  • rafts
  • synaptic transmission
  • membrane fusion
  • signal transduction


Biophysicists, physical chemists, cell biologists, and biomedical engineers.


No. of pages:
© Academic Press 2002
14th March 2002
Academic Press
eBook ISBN:
eBook ISBN:


@qu:"...a highy quality book with authoritative reviews, useful citations, and adequate illustrative material. The field is of increasing interest and the contribution is timely." @source:—DOODY'S NOTES (2002)

Ratings and Reviews

About the Editors

Sidney Simon

Affiliations and Expertise

Department of Neurobiology, Duke University Medical Center, Durham, NC, USA

Thomas McIntosh

Affiliations and Expertise

Duke University Medical Center, Durham, North Carolina, U.S.A.