PART I: Biophysical Techniques for Analyzing Peptide-Lipid Interactions Peptide-Membrane Interactions Determined Using Site Directed Spin Labeling. Isothermal Titration Calorimetry to Study Interactions Between Peptides and Lipid Membranes. Infrared Reflection-Absorption Spectroscopy of Lipids, Peptides, and Proteins in Aqueous Monolayers. Measuring the Depth of Amino Acid Residues in Membrane-Inserted Peptides by Fluorescence Quenching. Surface-sensitive X-ray and Neutron Scattering Characterization of Planar Lipid Model membranes and Lipid/Peptide Interactions. Lipid-Peptide Interactions Investigated by NMR. Peptide-Lipid Interactions in Supported Monolayers and Bilayers.
Part II: Theoretical and Computational Analyses of Peptide-Lipid Interactions Free Energy Determinants of Peptide Association with Lipid Bilayers. Investigating Ion Channels Using Computational Methods.
Part III: Experimental Investigations of Peptide-Lipid Interactions The Role of Electrostatic and Nonpolar Interactions in the Association of Peripheral Proteins with Membranes. The Energetics of Peptide-Lipid Interactions: Modulation by Interfacial Dipoles and Cholesterol. Transmembrane Alpha Helices. Lipidated Peptides as Tools to Understand the Membrane Interactions of Lipid-modified Proteins. Experimental and Computational Studies of the Interactions of Amphipathic Peptides with Lipid Surfaces. Interactions of pH-Sensitive Peptides and Polymers with Lipid Bilayers: Binding and Membrane Stability. The Hydrophobicity Threshold for Peptide Insertion into Membranes.
Part IV: Specialized Topics of Biological Relevance Signal Sequence Function in the Mammalian Endoplasmic Reticulum: A Biological Perspective. The Process of Membrane Fusion: Nipples, Hemifusion Pores, and Pore Growth. Prenylation of CaaX-Type Proteins: Basic Principles through Clinical Applications. Peptides as Probes of Protein-Protein Interactions Involved in Neurotransmitter Release.
This volume contains a comprehensive overview of peptide-lipid interactions by leading researchers. The first part covers theoretical concepts, experimental considerations, and thermodynamics. The second part presents new results obtained through site-directed EPR, electron microscopy, NMR, isothermal calorimetry, and fluorescence quenching. The final part covers problems of biological interest, including signal transduction, membrane transport, fusion, and adhesion.
@introbul:Key Features @bul:* world-renowned experts
- state-of-the-art experimental methods
- monolayers, bilayers, biological membranes
- theoretical aspects and computer simulations
- synaptic transmission
- membrane fusion
- signal transduction
Biophysicists, physical chemists, cell biologists, and biomedical engineers.
- No. of pages:
- © Academic Press 2002
- 14th March 2002
- Academic Press
- eBook ISBN:
- eBook ISBN:
@qu:"...a highy quality book with authoritative reviews, useful citations, and adequate illustrative material. The field is of increasing interest and the contribution is timely." @source:DOODY'S NOTES (2002)
Department of Neurobiology, Duke University Medical Center, Durham, NC, USA
Duke University Medical Center, Durham, North Carolina, U.S.A.
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