This volume contains a comprehensive overview of peptide-lipid interactions by leading researchers. The first part covers theoretical concepts, experimental considerations, and thermodynamics. The second part presents new results obtained through site-directed EPR, electron microscopy, NMR, isothermal calorimetry, and fluorescence quenching. The final part covers problems of biological interest, including signal transduction, membrane transport, fusion, and adhesion.

Key Features

@introbul:Key Features @bul:* world-renowned experts * state-of-the-art experimental methods * monolayers, bilayers, biological membranes * theoretical aspects and computer simulations * rafts * synaptic transmission * membrane fusion * signal transduction


Biophysicists, physical chemists, cell biologists, and biomedical engineers.

Table of Contents

PART I: Biophysical Techniques for Analyzing Peptide-Lipid Interactions Peptide-Membrane Interactions Determined Using Site Directed Spin Labeling. Isothermal Titration Calorimetry to Study Interactions Between Peptides and Lipid Membranes. Infrared Reflection-Absorption Spectroscopy of Lipids, Peptides, and Proteins in Aqueous Monolayers. Measuring the Depth of Amino Acid Residues in Membrane-Inserted Peptides by Fluorescence Quenching. Surface-sensitive X-ray and Neutron Scattering Characterization of Planar Lipid Model membranes and Lipid/Peptide Interactions. Lipid-Peptide Interactions Investigated by NMR. Peptide-Lipid Interactions in Supported Monolayers and Bilayers. Part II: Theoretical and Computational Analyses of Peptide-Lipid Interactions Free Energy Determinants of Peptide Association with Lipid Bilayers. Investigating Ion Channels Using Computational Methods. Part III: Experimental Investigations of Peptide-Lipid Interactions The Role of Electrostatic and Nonpolar Interactions in the Association of Peripheral Proteins with Membranes. The Energetics of Peptide-Lipid Interactions: Modulation by Interfacial Dipoles and Cholesterol. Transmembrane Alpha Helices. Lipidated Peptides as Tools to Understand the Membrane Interactions of Lipid-modified Proteins. Experimental and Computational Studies of the Interactions of Amphipathic Peptides with Lipid Surfaces. Interactions of pH-Sensitive Peptides and Polymers with Lipid Bilayers: Binding and Membrane Stability. The Hydrophobicity Threshold for Peptide Insertion into Membranes. Part IV: Specialized Topics of Biological Relevan


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© 2002
Academic Press
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@qu:"...a highy quality book with authoritative reviews, useful citations, and adequate illustrative material. The field is of increasing interest and the contribution is timely." @source:—DOODY'S NOTES (2002)