Peptide-Lipid Interactions, Volume 52

1st Edition

Editors: Sidney Simon Thomas McIntosh
Hardcover ISBN: 9780121533526
eBook ISBN: 9780080490960
Imprint: Academic Press
Published Date: 14th March 2002
Page Count: 601

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Table of Contents

PART I: Biophysical Techniques for Analyzing Peptide-Lipid Interactions Peptide-Membrane Interactions Determined Using Site Directed Spin Labeling. Isothermal Titration Calorimetry to Study Interactions Between Peptides and Lipid Membranes. Infrared Reflection-Absorption Spectroscopy of Lipids, Peptides, and Proteins in Aqueous Monolayers. Measuring the Depth of Amino Acid Residues in Membrane-Inserted Peptides by Fluorescence Quenching. Surface-sensitive X-ray and Neutron Scattering Characterization of Planar Lipid Model membranes and Lipid/Peptide Interactions. Lipid-Peptide Interactions Investigated by NMR. Peptide-Lipid Interactions in Supported Monolayers and Bilayers. Part II: Theoretical and Computational Analyses of Peptide-Lipid Interactions Free Energy Determinants of Peptide Association with Lipid Bilayers. Investigating Ion Channels Using Computational Methods. Part III: Experimental Investigations of Peptide-Lipid Interactions The Role of Electrostatic and Nonpolar Interactions in the Association of Peripheral Proteins with Membranes. The Energetics of Peptide-Lipid Interactions: Modulation by Interfacial Dipoles and Cholesterol. Transmembrane Alpha Helices. Lipidated Peptides as Tools to Understand the Membrane Interactions of Lipid-modified Proteins. Experimental and Computational Studies of the Interactions of Amphipathic Peptides with Lipid Surfaces. Interactions of pH-Sensitive Peptides and Polymers with Lipid Bilayers: Binding and Membrane Stability. The Hydrophobicity Threshold for Peptide Insertion into Membranes. Part IV: Specialized Topics of Biological Relevan

Description

This volume contains a comprehensive overview of peptide-lipid interactions by leading researchers. The first part covers theoretical concepts, experimental considerations, and thermodynamics. The second part presents new results obtained through site-directed EPR, electron microscopy, NMR, isothermal calorimetry, and fluorescence quenching. The final part covers problems of biological interest, including signal transduction, membrane transport, fusion, and adhesion.

Key Features

@introbul:Key Features @bul:* world-renowned experts

  • state-of-the-art experimental methods
  • monolayers, bilayers, biological membranes
  • theoretical aspects and computer simulations
  • rafts
  • synaptic transmission
  • membrane fusion
  • signal transduction

Readership

Biophysicists, physical chemists, cell biologists, and biomedical engineers.


Details

No. of pages:
601
Language:
English
Copyright:
© Academic Press 2002
Published:
Imprint:
Academic Press
eBook ISBN:
9780080490960
eBook ISBN:
9780080925851
Hardcover ISBN:
9780121533526

Reviews

@qu:"...a highy quality book with authoritative reviews, useful citations, and adequate illustrative material. The field is of increasing interest and the contribution is timely." @source:—DOODY'S NOTES (2002)


About the Editors

Sidney Simon Editor

Affiliations and Expertise

Department of Neurobiology, Duke University Medical Center, Durham, NC, USA

Thomas McIntosh Editor

Affiliations and Expertise

Duke University Medical Center, Durham, North Carolina, U.S.A.