The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research.

Key Features

  • Discusses the most recent data, ideas and concepts
  • Presents case studies and an industrial perspective
  • Details information from the molecular level to bioprocessing
  • Thought provoking, for the novice to the specialist
  • Timely, for today's biopharmaceuticals market


Entry level professionals and researchers working on interdisciplinary and collaborative projects in therapeutic research, including: biochemistry, pharmacology, chemistry, medicine, biomedicine, biotechnology, and immunology.  Graduate students studying peptide and protein drug delivery

Table of Contents




Chapter 1. An Overview of the Field of Peptide and Protein Delivery

1.1. Introduction

1.2. Current Formulation Development

1.3. Case Studies of Delivery Approaches: Cyclosporine A and Insulin

1.4. Controlled Delivery

1.5. Future Trends

1.6. Toxicity Profiles

1.7. Regulatory Matters

1.8. Commercialization Considerations

Chapter 2. Pulmonary Delivery of Peptides and Proteins

2.1. Introduction

2.2. Clinical Applications of Pulmonary Protein Delivery

2.3. Stability of Proteins and Peptides in Pulmonary Delivery Formulations

2.4. Types of Pulmonary Delivery Formulations

2.5. Packaging and Storage

2.6. Conclusions

Chapter 3. Nasal Delivery of Peptides and Proteins with Chitosan and Related Mucoadhesive Polymers

3.1. Introduction

3.2. Physiological Obstacles to Nasal Absorption

3.3. Mechanisms of Mucoadhesion

3.4. Mucoadhesive Polymers and Nasal Application

3.5. Thermal and pH Sensitive Polymers

3.6. Characterization and Evaluation of Mucoadhesive Polymers

3.7. Nasal (Ciliary) Toxicity

3.8. Nose to Brain Pathway: Future Considerations

Chapter 4. Transdermal Delivery of Peptides and Proteins

4.1. Introduction

4.2. Skin Structure

4.3. Rationale and Challenges for Transdermal Delivery of Peptides and Proteins

4.4. Techniques Enabling Transdermal Delivery of Peptides and Proteins

4.5. Conclusions

Chapter 5. Ocular Delivery of Peptides and Proteins

5.1. Introduction

5.2. The Physiology of the Eye and Challenges to the Delivery of Biomacromolecules

5.3. Considerations and Opportunities for Protein/Peptide Ocular Delivery

5.4. Peptide Transport Systems in the Eye

5.5. Strategies for the Ocular Delivery of Proteins and Pe


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© 2011
Academic Press
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