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Peptide and Protein Delivery - 1st Edition - ISBN: 9780123849359, 9780123849366

Peptide and Protein Delivery

1st Edition

Editor: Chris Van Der Walle
eBook ISBN: 9780123849366
Hardcover ISBN: 9780123849359
Imprint: Academic Press
Published Date: 12th May 2011
Page Count: 380
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The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research.

Key Features

  • Discusses the most recent data, ideas and concepts
  • Presents case studies and an industrial perspective
  • Details information from the molecular level to bioprocessing
  • Thought provoking, for the novice to the specialist
  • Timely, for today's biopharmaceuticals market


Entry level professionals and researchers working on interdisciplinary and collaborative projects in therapeutic research, including: biochemistry, pharmacology, chemistry, medicine, biomedicine, biotechnology, and immunology. Graduate students studying peptide and protein drug delivery

Table of Contents




Chapter 1. An Overview of the Field of Peptide and Protein Delivery

1.1. Introduction

1.2. Current Formulation Development

1.3. Case Studies of Delivery Approaches: Cyclosporine A and Insulin

1.4. Controlled Delivery

1.5. Future Trends

1.6. Toxicity Profiles

1.7. Regulatory Matters

1.8. Commercialization Considerations

Chapter 2. Pulmonary Delivery of Peptides and Proteins

2.1. Introduction

2.2. Clinical Applications of Pulmonary Protein Delivery

2.3. Stability of Proteins and Peptides in Pulmonary Delivery Formulations

2.4. Types of Pulmonary Delivery Formulations

2.5. Packaging and Storage

2.6. Conclusions

Chapter 3. Nasal Delivery of Peptides and Proteins with Chitosan and Related Mucoadhesive Polymers

3.1. Introduction

3.2. Physiological Obstacles to Nasal Absorption

3.3. Mechanisms of Mucoadhesion

3.4. Mucoadhesive Polymers and Nasal Application

3.5. Thermal and pH Sensitive Polymers

3.6. Characterization and Evaluation of Mucoadhesive Polymers

3.7. Nasal (Ciliary) Toxicity

3.8. Nose to Brain Pathway: Future Considerations

Chapter 4. Transdermal Delivery of Peptides and Proteins

4.1. Introduction

4.2. Skin Structure

4.3. Rationale and Challenges for Transdermal Delivery of Peptides and Proteins

4.4. Techniques Enabling Transdermal Delivery of Peptides and Proteins

4.5. Conclusions

Chapter 5. Ocular Delivery of Peptides and Proteins

5.1. Introduction

5.2. The Physiology of the Eye and Challenges to the Delivery of Biomacromolecules

5.3. Considerations and Opportunities for Protein/Peptide Ocular Delivery

5.4. Peptide Transport Systems in the Eye

5.5. Strategies for the Ocular Delivery of Proteins and Peptides

5.6. Future Perspectives

Chapter 6. Brain Delivery of Peptides and Proteins

6.1. Introduction

6.2. Peptides as Drugs for the Treatment of CNS Related Disorders

6.3. Transport of Protein and Peptide Drugs to the Brain

6.4. Strategies to Enhance the Delivery of Protein/Peptide to the CNS

6.5. Conclusion

Chapter 7. Chemically Modified Polyelectrolytes for Intestinal Peptide and Protein Delivery

7.1. Introduction

7.2. Characterization of Polyelectrolyte–Protein Complexes

7.3. Types of Chemically Modified Polyelectrolytes for Protein and Peptide Delivery

7.4. Conclusion

Chapter 8. Nanoparticle Mediated Oral Delivery of Peptides and Proteins

8.1. Introduction

8.2. Biological Barriers in Oral Peptide/Protein Delivery

8.3. Approaches for Oral Peptide/Protein Delivery

8.4. Nanoparticle Based Approaches

8.5. Stability and Evaluation

8.6. Oral Delivery of Nanoparticles: Further Considerations

8.7. Bioavailability

8.8. Biocompatibility and Toxicity Issues

8.9. Conclusions

Chapter 9. Modulation of the Intestinal Tight Junctions Using Bacterial Enterotoxins

9.1. Introduction

9.2. Tight Junction Composition

9.3. Signaling Pathways Regulating tj Functions

9.4. Tight Junction Modulators

9.5. Future Perspectives

Chapter 10. Peptide and Protein Delivery with Cell-penetrating Peptides

10.1. Introduction

10.2. The Diverse Family of CPPs

10.3. Delivery of Cargoes into Cells

10.4. Penetration Versus Endocytosis

10.5. After Endocytic Entry

10.6. Moving to In Vivo Systems

10.7. Conclusions and Future Aspects

Chapter 11. Peptide and Protein Bioconjugation

11.1. Introduction: Why Bioconjugation of Peptides and Proteins?

11.2. In Vivo Behavior of PEGylated Proteins

11.3. From Random to Site-Selective PEGylation

11.4. Restoring Pharmacodynamic Properties by Reversible PEGylation

11.5. Growing-from PEGylation

11.6. Stimuli Responsive Polymers

11.7. PEGylated Pharmaceuticals on the Market

Chapter 12. Peptide and Protein Application in Tissue Repair and Regeneration

12.1. Introduction: Medical Devices

12.2. Periodontal Defects

12.3. Bone Regeneration

12.4. Surgical Procedures

12.5. Human Medicines Approved or Under Development

12.6. Future Outlook

Chapter 13. Product Quality During Manufacture and Supply

13.1. Adverse Events Caused by the Loss of Product Quality

13.2. Types of Product Quality Loss

13.3. Parameters Critical to Product Quality

13.4. Regulating Product Quality

13.5. Bioprocess Design Considerations

13.6. Conclusion


Appendix 1. Calculated Properties of Some Clinically Relevant Peptides and Proteins

Appendix 2. Commonly Encountered Units and Abbreviations



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© Academic Press 2011
12th May 2011
Academic Press
eBook ISBN:
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About the Editor

Chris Van Der Walle

Chris Van Der Walle

Affiliations and Expertise

University of Strathclyde

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