Pediatric Immunology and Allergy, An Issue of Immunology and Allergy Clinics of North America

1st Edition, Volume 41-4 - October 6, 2021
Editor: Elizabeth Secord
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 2 0 0 0 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 2 0 0 1 - 8

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Cover image
Title page
Table of Contents
Copyright
Contributors
Forthcoming Issues
Preface
Humoral Immune Deficiencies of Childhood
Key points
Case 1
Case 2
Case 3
Summary
Innate Immunity
Key points
Components of the innate immunity
Innate immune recognition strategies and activation of the adaptive immune system
Toll-like receptors
Contribution of Toll-like receptor polymorphisms
Nucleotide oligomerization domain–like receptors
Implications of Toll-like receptor activation and modulation of immune response in allergy and infectious disease
Summary
Newborn Screening for Severe Combined Immunodeficiency
Key points
Introduction
History of severe combined immunodeficiency newborn screening
The T-cell receptor excision circle assay for severe combined immunodeficiency
Severe combined immunodeficiency subtypes and other conditions detected by T-cell receptor excision circles assay
Results of severe combined immunodeficiency newborn screening
Evaluation of infants with positive T-cell receptor excision circles results
Summary
New Treatments for Asthma
Key points
Introduction
Who are the candidates for emerging therapies?
Airway inflammatory phenotypes
Anti–Interleukin-4/Interleukin-13
Summary
Diagnosis and Management of Food Allergy
Key points
Introduction
Diagnosis
Management
Prevention
Treatments for food allergy
Summary
Eosinophilic Esophagitis
Key points
Introduction
Definition of eosinophilic esophagitis
Clinical features of eosinophilic esophagitis
Pathogenesis
Epidemiology
The role of food allergy and environmental allergy in eosinophilic esophagitis
Treatment of eosinophilic esophagitis
Summary
Pediatric Inner-City Asthma
Key points
Introduction
Prevalence
Morbidity and mortality
Risk factors for inner-city asthma
Interventions for inner-city asthma
Summary
Allergic Rhinitis in Children and Adolescents
Key points
Introduction
Summary
Anaphylaxis in Children and Adolescents
Key points
Introduction
Pathogenesis and classification
Epidemiology, morbidities, and mortalities
Causes
Diagnosis
Laboratory Findings
Management
Summary
Biologic Agents and Secondary Immune Deficiency
Key points
Tumor necrosis factor alpha inhibitors
Other classes of biologics
Reactivation of latent tuberculosis and other infections
New Insights and Treatments in Atopic Dermatitis
Key points
Introduction
Pathophysiology
Clinical features
Management
Janus kinase inhibitors
Other therapies
Summary
Pediatric Drug Allergies: Updates on Beta-Lactam, Nonsteroidal Anti-Inflammatory Drug, and Chemotherapeutic Reactions
Key points
Introduction
Prevalence
Characterization of hypersensitivity
Penicillin and other beta-lactam antibiotics
Special considerations
Desensitization considerations
Nonsteroidal anti-inflammatory drugs
Non–beta-lactam antibiotics
Sulfonamide antibiotics
Macrolides
Aminoglycosides
Fluoroquinolones
Chemotherapeutics
Platinum-based drugs (cisplatin, carboplatin, oxaliplatin)
l-Asparaginase (native Escherichia coli asparaginase, pegylated-asparaginase, Erwinia asparaginase)
Methotrexate
Anthracyclines (daunorubicin, doxorubicin, and epirubicin)
Vinca alkaloids (vincristine, vinblastine)
Summary

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Elizabeth Secord