Hematopathology of the Young, An Issue of the Clinics in Laboratory Medicine

Cover image

Title page

Table of Contents

Copyright

Contributors

Forthcoming Issues

Preface

Hematopathologic Correlates of CAR T-Cell Therapy

Key points

Introduction

Discussion

Pre-chimeric antigen receptor evaluation

Post-chimeric antigen receptor evaluation

Categorization of responses and relapses after chimeric antigen receptor T-cell therapy

Immunophenotype of chimeric antigen receptor T cells

Summary

Clinics care points

Disclosure

Antigen Loss after Targeted Immunotherapy in Hematological Malignancies

Key points

Introduction

Overview of targeted immunotherapies

Immune targeting and antigen escape

Impact on diagnosis

Mechanisms of antigen loss

Summary

Clinics care points

Update on Pediatric and Young Adult Mature Lymphomas

Key points

Introduction

Hodgkin lymphoma

Non-Hodgkin lymphoma

Clinics care points

Disclosure

The Hematological Differential Diagnosis of Mediastinal Masses

Key points

Introduction

Discussion Classic hodgkin lymphoma

Primary mediastinal (thymic) large B-cell lymphoma and gray zone lymphoma (B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classic Hodgkin lymphoma)

T-Lymphoblastic leukemia/lymphoma

Thymic lesions

Anaplastic large cell lymphoma

Other hematologic malignancies

Benign mediastinal lesions

Summary

Clinics care points

Disclosure

Update on Lymphoblastic Leukemia/Lymphoma

Key points

Introduction

Terminology

Classification

B-lymphoblastic leukemia/lymphoma

Clinics care points

Inherited Bone Marrow Failure Syndromes: Biology and Diagnostic Clues

Key points

Overview

Fanconi anemia: a DNA repair disorder

Dyskeratosis congenita: a telomeropathy

Shwachman-Diamond syndrome: a ribosomal biogenesis disorder

Diamond-Blackfan Anemia: a ribosomal biogenesis disorder

Congenital dyserythropoietic anemias

Severe congenital neutropenia

Congenital amegakaryocytic thrombocytopenia

Thrombocytopenia with absent radii

Summary

Clinics care points

Reactive Lymphadenopathies

Key points

Introduction

Discussion

Clinics care points

Update on Acute Leukemias of Ambiguous Lineage

Key points

Introduction

Incidence

Morphology

Immunophenotyping

Acute Undifferentiated Leukemia

Cytogenetic findings

Mutational analysis

Differential diagnosis of mixed-phenotype acute leukemia

Current treatment guidelines

Posttreatment follow-up and minimal residual disease testing

Summary

Clinics care points

Role of Minimal Residual Disease Testing in Acute Myeloid Leukemia

Key points

Introduction

Definition of remission and concept of measurable residual disease

Techniques to assess measurable residual disease

Applications of measurable residual disease data in acute myeloid leukemia

Challenges in measurable residual disease assessment

Summary

Clinics care points

Laboratory Aspects of Minimal / Measurable Residual Disease Testing in B-Lymphoblastic Leukemia

Key points

Introduction

Clinical minimal residual disease testing

Clinics care points

Molecular Genetics of Pediatric Acute Myeloid Leukemia

Key points

Introduction

Discussion

Summary

Clinics care points

Disclosure

Pediatric Myelodysplastic Syndromes

Key points

Clinical and laboratory parameters

Classification schema

Molecular genetic features

Clinical management

Summary

Clinics care points

Pediatric Myeloproliferative Neoplasms

Key points

Essential thrombocythemia

Polycythemia vera

Primary myelofibrosis

Chronic myeloid leukemia

Summary

Infant Acute Leukemia

Key points

Clinics care points

Gene Rearrangement Detection in Pediatric Leukemia

Key points

Introduction

Clinical significance of gene rearrangements

Methods to detect gene rearrangements

Summary

Clinics care points