Patterning and Cell Type Specification in the Developing CNS and PNS

Patterning and Cell Type Specification in the Developing CNS and PNS

Comprehensive Developmental Neuroscience

1st Edition - May 6, 2013

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  • Editors-in-Chief: John Rubenstein, Pasko Rakic
  • Hardcover ISBN: 9780123972651
  • eBook ISBN: 9780123973481

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The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 1 offers 48 high level articles devoted mainly to patterning and cell type specification in the developing central and peripheral nervous systems.

Key Features

  • Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop
  • Features leading experts in various subfields as Section Editors and article Authors
  • All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship
  • Volume 1 sections include coverage of mechanisms which: control regional specification, regulate proliferation of neuronal progenitors and control differentiation and survival of specific neuronal subtypes, and controlling development of non-neural cells


Neurosciencentists (developmental and translational) and developmental biology researchers

Table of Contents

  • Part I: Induction and Patterning of the CNS and PNS
    1. Telencephalon Patterning
    S. Tole, J. Hébert
    2. Morphogens, Patterning Centers, and their Mechanisms of Action
    E.A. Grove, E.S. Monuki
    3. Midbrain Patterning: Isthmus Organizer, Tectum Regionalization, and Polarity Formation
    H. Nakamura
    4. Area Patterning of the Mammalian Cortex
    D.D.M. O'Leary, A.M. Stocker, A. Zembrzycki
    5. The Formation and Maturation of Neuromuscular Junctions
    C.R. Hayworth, R.J. Balice-Gordon
    6. Neural Induction of Embryonic Stem/Induced Pluripotent Stem Cells
    K. Brennand, F. Gage
    7. Spinal Cord Patterning
    W.D. Gifford, M. Hayashi, M. Sternfeld, J. Tsai, W.A. Alaynick, S.L. Pfaff
    8. Patterning of the Diencephalon
    L. Puelles, S. Martinez
    9. Neural Induction Embryonic Stem Cells
    C. Kintner, A. Hemmati-Brivanlou
    10. Plan of the Developing Vertebrate Nervous System: Relating Embryology to the Adult Nervous System (Prosomere Model, Overview of Brain Organization)
    L. Puelles
    11. Cerebellar Patterning
    J.K. Fahrion, Y. Komuro, N. Ohno, Y. Littner, C. Nelson, T. Kumada, B. Lamb, H. Komuro
    12. Hox Genes and Neural Patterning in Drosophila
    P.A. Kuert, H. Reichert
    13. Induction and Patterning of Neural Crest and Ectodermal Placodes and their Derivatives
    J. Begbie

    Part II: Generation of Neuronal Diversity
    14. Cell Biology of Neuronal Progenitor Cells
    S. Temple, Q. Shen
    15. Cell Cycle Regulation in Brain Construction
    M. Crespo, M.E. Ross
    16. Regulation of Neuronal Survival by Neurotrophins in the Developing Peripheral Nervous System
    A.M. Davies
    17. Notch and Neural Development
    J.J. Breunig, B.R. Nelson
    18. bHLH Factors in Neurogenesis and Neuronal Subtype Specification
    H.C. Lai, D.M. Meredith, J.E. Johnson
    19. Environmental Cues and Signaling Pathways that Regulate Neural Precursor Development
    A. Gauthier-Fisher, F.D. Miller
    20. Specification of Neural Crest- and Placode-Derived Neurons
    L. Sommer
    21. The Specification and Generation of Neurons in the Ventral Spinal Cord
    M. Matise, K. Sharma
    22. Neurogenesis in the Cerebellum
    V.V. Chizhikov, K.J. Millen
    23. The Generation of Midbrain Dopaminergic Neurons
    S.R.W. Stott, S.-L. Ang
    24. Neurogenesis in the Basal Ganglia
    J.L.R. Rubenstein, K. Campbell
    25. Specification of Cortical Projection Neurons: Transcriptional Mechanisms
    J.L. MacDonald, R.M. Fame, E. Azim, S.J. Shnider, B.J. Molyneaux, P. Arlotta, J.D. Macklis
    26. The Generation of Cortical Interneurons
    R. Batista-Brito, G. Fishell
    27. Specification of Retinal Cell Types
    R.B. Hufnagel, N.L. Brown
    28. Neurogenesis in the Postnatal VZ-SVZ and the Origin of Interneuron Diversity
    A. Alvarez-Buylla, F. Merkle, L. Fuentealba
    29. Neurogenesis in the Damaged Mammalian Brain
    M. Nakafuku, A. Grande
    30. Neurogenesis in the Nematode Caenorhabditis elegans*
    O. Hobert
    31. Development of the Drosophila Embryonic Ventral Nerve Cord: From Neuroectoderm to Unique Neurons and Glia
    J. Benito-Sipos, M. Baumgardt, S. Thor
    32. Neurogenesis in Zebrafish
    A. Alunni, M. Coolen, I. Foucher, L. Bally-Cuif

    Part III: Development of Glia, Blood Vessels, Choroid Plexus, Immune Cells in the Nervous System
    33. ‘Glial’ Biology: Has it Come to the Beginning of the End?
    D. Rowitch, A. Alvarez-Buylla
    34. Neural Stem Cells Among Glia
    A. Alvarez-Buylla, A. Kriegstein
    35. Structure and Function of Myelinated Axons
    S.A. Buffington, M.N. Rasband
    36. Mechanisms of Astrocyte Development
    A.V. Molofsky, C. Hochstim, B. Deneen, D. Rowitch
    37. Specification of Macroglia by Transcription Factors: Oligodendrocytes
    M. Wegner
    38. Specification of Macroglia by Transcription Factors: Schwann Cells
    D. Meijer, J. Svaren
    39. Signaling Pathways that Regulate Glial Development and Early Migration Oligodendrocytes
    R.H. Miller
    40. Signaling Pathways that Regulate Glial Development and Early Migration Schwann Cells
    K.R. Jessen, R. Mirsky
    41. Microglia
    A.E. Cardona, R.M. Ransohoff, K. Akassoglou
    42. Ependyma, Choroid
    A. Meunier, K. Sawamoto, N. Spassky
    43. Meninges and Vasculature
    J.A. Siegenthaler, S.J. Pleasure
    44. Neuron–Glial Interactions: Schwann Cells
    M.H. Schwab, M.W. Sereda, K.-A. Nave
    45. Neuron–Glial Interactions: Neurotransmitter Signaling to Cells of the Oligodendrocyte Lineage
    L.M. De Biase, D.E. Bergles
    46. Invertebrate Glia
    T. Stork, M.R. Freeman
    47. Nonmammalian Model Systems: Zebrafish
    B. Appel
    48. New Approaches in Glial Biology: Imaging Neuroglial Pathology In Vivo
    I. Nikić, T. Misgeld, M. Kerschensteiner

Product details

  • No. of pages: 992
  • Language: English
  • Copyright: © Academic Press 2013
  • Published: May 6, 2013
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123972651
  • eBook ISBN: 9780123973481

About the Editors in Chief

John Rubenstein

Dr. Rubenstein is a Professor in the Department of Psychiatry at the University of California, San Francisco. He also serves as a Nina Ireland Distinguished Professor in Child Psychiatry at the Nina Ireland Laboratory of Developmental Neurobiology. His research focuses on the regulatory genes that orchestrate development of the forebrain. Dr. Rubenstein's lab has demonstrated the role of specific genes in regulating neuronal specification, differentiation, migration and axon growth during embryonic development and on through adult life. His work may help to explain some of the mechanisms underlying human neurodevelopmental disorders such as autism.

Affiliations and Expertise

Professor, Department of Psychiatry, University of California, San Francisco, USA

Pasko Rakic

Dr. Rakic is currently at the Yale School of Medicine, Department of Neuroscience, where his main research interest is in the development and evolution of the human brain. After obtaining his MD from the University of Belgrade School of Medicine, his research career began in 1962 with a Fulbright Fellowship at Harvard University after which he obtained his graduate degrees in Developmental Biology and Genetics. He held a faculty position at Harvard Medical School for 8 years prior to moving to Yale University, where he founded and served as Chair of the Department of Neurobiology for 37 years, and also founder and director of the Kavli Institute for Neuroscience. In 2015, he returned to work full-time on his research projects, funded by US Public Health Services and various private foundations. He is well known for his studies of the development and evolution of the brain, in particular his discovery of basic cellular and molecular mechanisms of proliferation and migration of neurons in the cerebral cortex. He was president of the Society for Neuroscience and popularized this field with numerous lectures given in over 35 counties. In 2008, Rakic shared the inaugural Kavli Prize in Neuroscience with Thomas Jessell and Stan Grillner. He is currently the Dorys McConell Duberg Professor of Neuroscience and serves on Advisory Boards and Scientific Councils of a number of Institutions and Research Foundations.

Affiliations and Expertise

Department of Neuroscience, Yale School of Medicine, USA

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  • NikolaiFedorchak Fri Jun 07 2019

    Patterning and Cell Type Specification in the Developing CNS and PNS

    This book helped me better understand how the CNS develops. The illustrations are easy to comprehend and the literature (15-20 ish pages per chapter) summarizes the research succinctly. I recommend this book and the rest of the Comprehensive Developmental Neuroscience series to anyone who has a legitimate desire to learn more about developmental vertebrate neuroscience.