Pathophysiology - 6th Edition - ISBN: 9780323065849, 9780323316071


6th Edition

The Biologic Basis for Disease in Adults and Children

Authors: Kathryn McCance Sue Huether
eBook ISBN: 9780323316071
eBook ISBN: 9780323065825
Imprint: Mosby
Published Date: 19th November 2009
Page Count: 1864

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Well-known for its authoritative and comprehensive coverage, complete treatment of pediatric pathophysiology, and the most extensive illustration program in its field, this textbook features expert content on everything from the general principles of pathophysiology to detailed discussions of genetics and specific diseases. Chapters on alteration present the pathophysiology, clinical manifestations, and evaluation and treatment of each disease to help you learn to identify normal anatomy and physiology, as well as alterations of function in adults and in children.

Key Features

  • Unparalleled coverage of disease processes makes this text the most comprehensive pathophysiology text available.
  • The largest full-color art program in the field illustrates the clinical manifestations of diseases and disease processes
  • Consistent presentations of each disease with pathophysiology, clinical manifestations, and evaluation and treatment help you find the information you need quickly and easily.
  • Ten separate pediatric chapters cover the pathophysiologic effects on children.
  • Aging content is highlighted throughout the text.
  • An Introduction to Pathophysiology section at the beginning of the text provides a solid start to the basics of the study of disease.
  • Algorithms and flowcharts of diseases and disorders illustrate the disease process in an easy-to-understand format.
  • Nutrition and Disease boxes present evidence-based information on the relationship between health promotion through diet and disease.

Table of Contents

Introduction to Pathophysiology


Unit I: The Cell

  1. Cellular Biology
  2. Altered Cellular and Tissue Biology
  3. The Cellular Environment: Fluids and Electrolytes, Acids and Bases
  4. Unit II: Genes and Gene-Environment Interaction

  5. Genes and Genetic Diseases
  6. Genes, Environment, Life-style, and Common Diseases
  7. Unit III: Mechanisms of Self-Defense

  8. Innate Immunity: Inflammation
  9. Adaptive Immunity
  10. Alterations in Immunity and Inflammation
  11. Infection
  12. Stress and Disease
  13. Unit IV: Cellular Proliferation: Cancer

  14. Biology, Clinical Manifestations, and Treatment of Cancer
  15. Cancer Epidemiology
  16. Cancer in Children

    Unit V: The Neurologic System

  18. Structure and Function of the Neurologic System
  19. Pain, Temperature Regulation, Sleep, and Sensory Function
  20. Alterations in Cognitive Systems, Cerebral Hemodynamics and Motor Function
  21. Disorders of the Central and Peripheral Nervous Systems and the Neuromuscular Junction
  22. Neurobiology of Schizophrenia, Mood Disorders, and Anxiety Disorders
  23. Alterations of Neurologic Function in Children
  24. Unit VI: The Endocrine System

  25. Mechanisms of Hormonal Regulation
  26. Alterations of Hormonal Regulation
  27. Unit VII: The Reproductive Systems

  28. Structure and Function of the Reproductive Systems
  29. Alterations of the Reproductive Systems
  30. Sexually Transmitted Infections
  31. Unit VIII: The Hematologic System

  32. Structure and Function of the Hematologic System
  33. Alterations of Erythrocyte Function
  34. Alterations of Leukocyte, Lymphoid, and Hemostatic Function
  35. Alterations of Hematologic Function in Children
  36. Unit IX: The Cardiovascular and Lymphatic Systems

  37. Structure and Function of the Cardiovascular and Lymphatic Systems
  38. Alterations of Cardiovascular Function
  39. Alterations of Cardiovascular Function in Children
  40. Unit X: The Pulmonary System

  41. Structure and Function of the Pulmonary System
  42. Alterations of Pulmonary Function
  43. Alterations of Pulmonary Function in Children
  44. Unit XI: The Renal and Urologic System

  45. Structure and Function of the Renal and Urologic Systems
  46. Alterations of Renal and Urinary Tract Function
  47. Alterations of Renal and Urinary Tract Function in Children
  48. Unit XII: The Digestive System

  49. Structure and Function of the Digestive System
  50. Alterations of Digestive Function
  51. Alterations of Digestive Function in Children
  52. Unit XIII: The Musculoskeletal System

  53. Structure and Function of the Musculoskeletal System
  54. Alterations of Musculoskeletal Function
  55. Alterations of Musculoskeletal Function in Children
  56. Unit XIV: The Integumentary System

  57. Structure, Function, and Disorders of the Integument
  58. Alterations of the Integument in Children
  59. Unit XV: Multiple Interacting Systems

  60. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults
  61. Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children


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About the Author

Kathryn McCance

Affiliations and Expertise

Professor, College of Nursing, University of Utah, Salt Lake City, UT

Sue Huether

Affiliations and Expertise

Professor Emeritus, College of Nursing, University of Utah, Salt Lake City, UT