Pathophysiology, Risk factors and Management of Chronic Heart Failure, Volume 1

Pathophysiology, Risk factors and Management of Chronic Heart Failure, Volume 1

1st Edition - January 10, 2023

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  • Editors: Ram Singh, Jan Fedacko, Krasimira Hristova, Galal Nagib Elkilany
  • Paperback ISBN: 9780128229729

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Chronic Heart Failure: Pathophysiology, Risk factors, and Mechanisms is the first of two separate but closely related volumes which aim to provide an inclusive overview on Chronic Heart Failure (CHF). This first volume is focused on the epidemiology, classification, molecular mechanisms, pathophysiology, causes, identification and interactions of heart failure. It will explain the uncertainties and issues in Heart Failure by helping readers understand the physiopathology of CHF in the light of behavioural risk factors. 2D and 3D speckle tracking echocardiography have been used to quantify regional alterations of longitudinal strain and area strain, through their polar projection, which allows a further evaluation of both the site and extent of myocardial damage. The analysis of strain can identify subclinical cardiac failure (myocyte remodelling) which is a major issue in CHF. Myocardial Strain, measure by speckle tracking echocardiography, is frequently attenuated in these conditions and can be utilized for the evaluation of disease progression and the effect of therapeutic interventions as well as prevention because it could be a manifestation of behavioural risk factors. These 2 separate volumes serves as essential references to both researchers and practicing clinicians, proposing novel methods of research by using behavioural and environmental risk factors as intervention agent, as well as discussing deficiency in the present approaches in management of HF and proposing new methods of early diagnosis and therapies for the clinical management of CHF.

Key Features

  • Includes a number new and controversial topics: Roles of both behavioural and nutritional risk factors in CHF; considering behavioural intervention which may change the remodelling, as well as nutrient supplementation or change of diet in preventing CHF or converting resistant HF in to HF responding to therapy; Evidence-based knowledge on CHF, with an emphasis on viewing CHF as a disease of the brain and contribution from other systems; Pre–Heart failure which can be prevented to restore normal cardiomyocyte function; Pathogenesis of HF in chronic kidney disease; 2D and 3D speckle tracking echocardiography
  • Includes never-published tables and figures to aid understanding of the topics
  • Contributions from international leading experts in the field, written with the aim of serving both researchers and practicing clinicians


Cardiologists, echocardiographists, researchers, physicians, biochemists, pharmacologists, pharmacists, nutrition scientists, dietitians, experts developing guidelines, endocrinologists, nephrologists, neurologist, neuro-endocrinologists, community medicine and public health workers and policy makers

Table of Contents

  • Section 1. History, Epidemiology and Burden due to chronic heart Failure
    1. Introduction
    2. Epidemiology and mortality due to heart failure
    3. Behavioral Risk factors of heart failure including Marijuana, and Electronic Cigarette Smoking
    4. Nutritional factors in the pathogenesis and prevention of HF
    5. Evolution of the natural history of myocardial function to the heart failure

    Section 2. Classification of heart failure
    6. Pre-heart failure and
    7. Classification of stages of heart failure

    Section 3. Molecular mechanisms in the Pathogenesis of Chronic Heart Failure
    8. Molecular and cellular biology of chronic heart failure
    9. Pathophysiology of chronic heart failure
    10. Circadian dysfunction in the pathogenesis of HF
    11. Cardiac remodelling in chronic heart failure
    12. Role of Obesity on Mitochondrial Dysfunction and Energy Imbalance in Heart Failure"

    Section 4. Pathophysiology of Cardiac Function
    13. Abnormalities in the cardiac contraction
    14. Abnormalities in the cardiac relaxation

    Section 5. Autonomic nervous system in CHF
    15. Role of Sympathetic nervous system in the chronic heart failure
    16. Role of Parasympathetic nervous system in the chronic heart failure
    17. The peripheral circulation in the chronic heart failure

    Section 6. Chronic heart failure and chronic kidney diseases
    18. Renal system in the chronic heart failure
    19. Heart failure in chronic kidney disease

    Section 7. Imaging in Chronic Heart Failure
    20. Role of non-invasive imaging with reference to Speckle Tracking
    21. Echocardiography in the chronic heart failure
    22. Usefulness of 2D and 3D echo in the assessment of systolic and diastolic LV dysfunction. More coverage will be given to diastolic heart failure
    23. Role of brain imaging in CHF

    Section 8. Causes of heart Failure
    24. Causes for chronic heart failure
    25. Coronary artery disease and heart failure
    26. Cardiomyopathies and HF
    27. Inflammatory and metabolic heart disease
    28. Valvular heart disease
    29. Congenital heart disease
    30. Right heart failure Cor pulmonale with reference to Health Care Burden of Cardiorespiratory Diseases and Heart Failure Caused by Air Pollutants and Microparticles
    31. Oncology and heart failure
    32. Acute heart failure
    33. High prevalence of undetected heart failure in longterm care residents: findings from the Heart Failure in Care Homes (HFinCH) study
    34. Analysing recurrent hospitalizations in heart failure: a review of statistical methodology, with application to CHARM-Preserved

Product details

  • No. of pages: 410
  • Language: English
  • Copyright: © Academic Press 2023
  • Published: January 10, 2023
  • Imprint: Academic Press
  • Paperback ISBN: 9780128229729

About the Editors

Ram Singh

Dr. Ram B Singh is president of the Tsim Tsoum Insitutute in Krakow, Poland. He's an honorary fellow of the Halberg Chronobiology Centre, a member of the Russian Academy of Medical Sciences, a fellow of the International Academy of Cardiovascular Sciences, and former president and founder of the Indian Society of Hypertension, International College of Cardiology, and International College of Nutrition. He is the editor of the World Heart Journal and former professor of medicine at Subharti Medical College. He has contributed over 500 research papers to peer reviewed journals and has edited seven books.

Affiliations and Expertise

Consultant Neuro-cardiologist, Halberg Hospital and Research Institute, Moradabad-10(UP), India

Jan Fedacko

Jan Fedacko, MD, PhD, FICC, FICN is Assistant Professor at Department of Medicine and Centre of Excellency for Atherosclerosis Research at Louis Pasteur University Hospital and Pavol Jozef Safarik University in Kosice, Slovak Republic. After obtaining a diploma in General Medicine of Pavol Jozef Safarik University in Kosice, Slovak Republic (2005) the Ph.D. study (negative pleiotropic effect of the statins and possibilities of its treatment) was completed in year 2010. He is member of executive board of International College of Cardiology, member of International College of Clinical Nutrition, Slovak Association of Cardiology, Slovak Association of Atherosclerosis and member of Editorial Advisory Board of several journals. In the clinical and research area he is focused on preventive cardiology, prevention and treatment of the atherosclerosis deseases, as well as in cardiac imagineg techniques. He has published several papers in domestic and international journals, including several international lectures.

Affiliations and Expertise

Associate Professor, 3rd Interna Clinic,Faculty of Medicine, PJ Safaric University, Kosice, Slovakia

Krasimira Hristova

Assoc. Prof. Dr. Krasimira Hristova is specialist cardiologist, expert of echocardiography at University National Heart Hospital, Sofia, Bulgaria and consulting cardiologist at Nadezhda Women’s Hospital , Sofia, Bulgaria . She earned a PhD in applying the newest echocardiographic methods for evaluating the myocardial deformation in patients, following acute myocardial infarction. Assoc. Prof. Hristova specialized in top-ranked universities in Austria and Belgium. She has earned a master’s degree in Advance Medical Imaging in cardiology at Catholic University Leuven, Belgium in 2009. She took part in the development and clinical implementation of the first software for 3D myocardial deformation, working in an international team with colleagues from Belgium and Norway. Authored many scientific papers, holder of the Young Researcher award of the International Society of Hypertension in 2006, she has received honors from multiple national and international organizations.

Affiliations and Expertise

Associated Professor of Cardiology, National Heart Hospital, Sofia, Bulgaria

Galal Nagib Elkilany

Dr. Galal Eldin Nagib Elkilany received his BSc and MSc degrees from Tanta University, Egypt and his PhD & MD from the Post-Graduate Institute of Cardiology Department, Tanta University School of Medicine, Egypt. He was a Research Fellow in Thorax Center, Rotterdam, Holland, Erasmus University in Stress Echocardiography Department on 2000/2001. He is a Cardiology Specialist and Faculty in Tanta University Hospital from 1991 until 1998. He also worked as Consultant Cardiologist -degree of Professor of Cardiology 1998-2015, Cairo, Egypt- law No. 115. He is a Clinical Fellow in Milano-Majore Policlinico, Milan, Italy 2007 in cardiac cath. He is a Lab and Partner clinical Fellowship and visitor physician at University of Alabama, Birmingham, USA in 2011. He received a price of Young Investigator Award from Egyptian Society of Cardiology on 1999 & 2001. He has many famous international publications to his credit.

Affiliations and Expertise

Assistant Clinical Professor of Cardiology, Gulf Medical University, UAE

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