Pathology, Vector Studies, and Culture

Pathology, Vector Studies, and Culture

1st Edition - January 28, 1980

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  • Editor: Julius P. Kreier
  • eBook ISBN: 9781483258713

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Malaria: Volume 2, Pathology, Vector Studies, and Culture is a collection of papers that deals with erythrocyte destruction mechanism in malaria, the pathology of malaria, colonization of laboratory mosquitoes, and their transmission of plasmodia. Other papers describe the culture of the invertebrate stages of plasmodia, of mosquito tissues, and also of erythrocytic and exoerythrocytic stages of plasmodia. One paper constructs a model to show the roles of the different destructive and regenerative processes in the mechanisms of erythrocyte destruction in malaria. Another paper describes the organ changes and physiopathological mechanism connected with Plasmodium infection. These organs concern the spleen, liver, heart, and vascular system. One paper reviews the procedures involved in malaria transmission by mosquitoes, as well as some specialized procedures unique in avian, rodent, simian, and human malarias. Another paper discusses the benefits and drawbacks of a culture medium based on the composition of adult anopheline hemolymph. This medium should lead to a rapid growth rate in primary cultures of mosquito cells and a shorter interval of adaptation for continuous cell lines. The collection can prove useful for pharmacologists, general medical practitioners, investigators, and laboratory technicians involved in mosquito borne diseases or tropical medicine research.

Table of Contents

  • List of Contributors


    Contents of Volumes 1 and 3

    Contents of Babesiosis

    1 Erythrocyte Destruction Mechanisms in Malaria

    I. Introduction

    II. Mechanisms of Erythrocyte Destruction

    III. Proposed Model of the Relationship between Erythrocyte Loss and Parasitemia


    2 Pathology of Malaria

    I. Introduction

    II. Spleen Pathology

    III. Liver Pathology

    IV. Heart and Vascular Pathology

    V. Hematopathology

    VI. Pulmonary Pathology

    VII. Thymus Pathology

    VIII. Renal Pathology

    IX. Neuropathology

    X. Placenta Pathology


    3 Colonization and Maintenance of Mosquitoes in the Laboratory

    I. Introduction

    II. Basic Mosquito Biology

    III. Collection of Field Material

    IV. Transport of Living Material

    V. Rearing

    VI. Selection Procedures

    VII. Pathogen and Pesticide Problems


    4 The Transmission by Mosquitoes of Plasmodia in the Laboratory

    I. Introduction

    II. Susceptibility of Mosquitoes to Plasmodium

    III. Gametocytes in the Vertebrate Host

    IV. The Infective Blood Meal

    V. Maintenance of Infected Mosquitoes

    VI. Sampling Procedures for Determining the Degree of Mosquito Infection

    VII. Harvesting, Purifying, and Maintaining Sporozoites

    VIII. Infecting Vertebrates with Sporozoites

    IX. Quantitation of Sporozoite Infectivity and Viability

    X. Specific Host-Parasite-Vector Systems in Malaria Research

    XI. Conclusions


    5 Culture of the Invertebrate Stages of Plasmodia and the Culture of Mosquito Tissues

    I. Introduction

    II. Attempts to Culture the Vertebrate Stages of Plasmodia

    III. Current Methods of Initiating Primary Cell and Organ Cultures from Mosquito Species with Emphasis on Anophelines

    IV. Adult Anopheline Hemolymph Analysis and the Design of Culture Media

    V. Concluding Remarks


    6 Cultivation of Erythrocytic and Exoerythrocytic Stages of Plasmodia

    I. Introduction

    II. Culture of Erythrocytic Stages within Their Host Cells

    III. Extracellular Culture of Erythrocytic Stages

    IV. Exoerythrocytic Stages in Culture



Product details

  • No. of pages: 346
  • Language: English
  • Copyright: © Academic Press 1980
  • Published: January 28, 1980
  • Imprint: Academic Press
  • eBook ISBN: 9781483258713

About the Editor

Julius P. Kreier

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