Pathobiology of Human Disease

Pathobiology of Human Disease

A Dynamic Encyclopedia of Disease Mechanisms

1st Edition - August 1, 2014

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  • Editors-in-Chief: Linda McManus, Richard Mitchell
  • eBook ISBN: 9780123864574

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Pathobiology of Human Disease bridges traditional morphologic and clinical pathology, molecular pathology, and the underlying basic science fields of cell biology, genetics, and molecular biology, which have opened up a new era of research in pathology and underlie the molecular basis of human disease. The work spans more than 48 different biological and medical fields, in five basic sections: Human Organ Systems Molecular Pathology/Basic Mechanisms of Diseases Animal Models/Other Model Systems Experimental Pathology Clinical Pathology Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers from research professionals to advanced undergraduate students.

Key Features

  • Reviews quantitative advances in the imaging and molecular analysis of human tissue, new microarray technologies for analysis of genetic and chromosomal alterations in normal and diseased cells and tissues, and new transgenic models of human disease using conditional, tissue-specific gene targeting
  • Articles link through to relevant virtual microscopy slides, illustrating side-by-side presentation of "Normal" and "Disease" anatomy and histology images
  • Fully-annotated with many supplementary full color images, graphs, tables, and video files linked to data sets and to live references, enabling researchers to delve deeper and visualize solutions


The work will be of interest particularly to graduate students in pathology, laboratory medicine, and a wide range of biomedical research fields such as cell biology, genetics, immunology, as well as pre-professional undergraduate students. It is of relevance to biomedical and medical researchers who teach and do research across pathology and human disease – as an authoritative resource for themselves and their students. Therefore, academic, government, corporate, and public libraries will all want to have access to the content in their collections.

Table of Contents

  • Adaptive Immune System
    Specialization in adaptive immunity
    Regulation and maintenance of adaptive immunity
    Allergy and hypersensitivity
    The Pathobiologic Basis of Autoimmunity
    Defining Traumatic Injuries
    Atrophy, hypertrophy and hyperplasia
    Ubiquitin-proteasome system
    Mechanisms of cell injury
    Endoplasmic reticulum: ER stress
    Mitochondrial calcium homeostasis in cell health and disease
    Inner Membrane Permeabilization – The Permeability Transition
    Extrinsic pathways: death receptors and granzymes
    Caspases: executioners of apoptosis
    Biological Toxins
    Regulation of Mitochondrial Apoptosis: Bcl-2 and its Family Members
    Laterality Disorders
    Chromosome 22q Abnormalities
    Sex Chromosome Abnormalities
    Triplet Repeat Disorders
    Imprinting Disorders
    Mitochondrial Myopathies
     Inborn Errors of Metabolism
    Muscular Dystrophies
    Other congenital myopathies
    Congenital Infection
    Perinatal Complications of Maternal Diabetes
    Sudden Infant Death Syndrome
    Neuroblastic Tumors
    Interactions of Pathogens with the Entire Host
    Diseases Caused by Fungi
    Principles of Diagnosis of Infectious Diseases
    An Overview of Inflammation
    The complement system
    Mediators and mechanisms of the increased blood flow, vascular permeability and blood vessel proliferation in inflamed tissue
    Cells of innate immunity: mechanisms of activation
    Recruitment of leukocytes: adhesion molecules and chemoattractants
    Phagocytes in inflammation
    Chronic inflammation
    Systemic Inflammation
    Sepsis: understanding the high mortality and high morbidity
    Resolution and Regulation of Inflammation
    An introduction to the conspicuous and distinguishing characteristics of neoplasms
    Epigenetic contributions to the cancer transcriptome
    Establishment of replicative immortality in cancer cells
    Mechanisms of resistance to cell death pathways in cancer cells
    Cancer angiogenesis and vasculogenesis
    The cancer tissue microenvironment
    Cancer invasion and metastasis
    Avoidance of cancer cell destruction by the immune system
    Deregulation of the cellular energetics of cancer cells
    Systemic effects of cancer
    Genetic and Epigenetics of Type 2 Diabetes
    Skeletal muscle glucose metabolism and insulin resistance
    Normal adipose tissue biology (adipokines and inflammation).
    Recent Advances in Genomics of Body Composition, Adipose Tissue Metabolism and its Relation to the Development of Obesity
    The gut microbiota and effects on metabolism.
    Infant malnutrition.
    Cell cycle and metabolic changes during tissue regeneration and remodeling
    Scar Formation & Skin Wound Healing
    Skin Regeneration
    Skeletal Muscle Remodeling and Regeneration
    Myocardial Remodeling and Regeneration
    Repair and Regeneration following Spinal Cord Injury
    Cell mediated rejection
    Allograft tolerance
    Pancreas and Islet Transplantation For The Treatment of Diabetes Mellitus
    Bone Marrow
    Biology of Normal Bone
    Cell, Biochemistry, and Molecular Biology of Bone
    Genetic Nonneoplastic Diseases
    Sporadic Acquired and Genetic Disorders of Bone
    Paget's Disease
    Metabolic Bone Diseases I
    Metabolic Bone Diseases II
    Benign Tumors and Tumor-like Conditions of Bone
    Malignant Tumors
    The Pathology of the Skeleton in Lysosomal Storage Diseases
    The Normal Breast and Risk Factors for Breast Cancer
    Proliferative Lesions and Preneoplastic Alterations
    Invasive Carcinoma
    Translational Cellular Model Systems to Study Breast Cancer
    Breast Cancer Metastasis: Clinical Considerations
    Ischemic Heart Disease
    Heart Valve Disease
    Myocarditis and other inflammatory myocardial disease (e.g., sarcoid)
    Cardiovasacular Pathology
    Influenza in animals
    Comparative Pancreatic Pathology
    Infectious Disease - Prions
    Skin: Basic Structure and Function
    Cutaneous Immunology
    Melanocytes and vitiligo (and hair graying)
    Disorders of Epidermal Maturation (ichthyosis)
    Inflammatory skin disorders
    Benign epithelial tumors
    Malignant epithelial tumors
    Benign melanocytic lesions and Melanoma
    Basic principles
    Thyroid - Inflammatory disease
    Thyroid - mouse models of thyroid neoplasia, insight into thyroid pathophysiology
    Pathophysiology and Neoplasia of the Adrenal Medulla and Extra-Adrenal Paraganglia
    Parathyroid: Pathophysiology and Molecular Mechanisms of Disease
    Development, structure and function of the tubal gut
    Small bowel
    The large bowel
    Inflammatory bowel disease
    Gastric cancer
    Gastrointestinal Polyposis Syndromes
    Colorectal cancer
    Heritable ovarian cancer
    Ovarian carcinogenesis
    Molecular basis for targeted therapy in gynecologic cancer
    Polycystic Ovarian Disease
    Viral associations with head and neck carcinoma: HPV
    Squamous dysplasia: pathogenesis and histologic grading
    Fungal infections in the head and neck
    Normal Hematopoiesis
    Normal Karyotype Acute Myelogenous Leukemia
    Chronic Lymphocytic Leukemia - Molecular pathology and relevance to novel therapies
    Molecular genetics of diffuse large B-cell lymphoma
    Mantle Cell Lymphoma
    Hodgkin Lymphoma and the microenvironment
    Plasma cell neoplasms: MGUS and Myeloma
    Follicular lymphoma: Early and late genetic events
    Pathobiology of peripheral T-Cell lymphomas
    Pathogenesis of pediatric acute lymphoblastic leukemias
    Cellular Anatomy of the Liver (Hepatocyte, Biliary Epithelial Cells (BEC), Hepatic Stellate Cells (HSC), Kupffer cells and Endothelial cells)
    Liver Physiology: Metabolism and Detoxification
    Liver Development, Regeneration, and Stem Cells
    Bioartificial Liver
    Hepatic fibrosis and cirrhosis
    Fatty liver, Non-alcoholic Steatohepatitis (NASH) and Alcoholic liver disease
    Drug-induced liver injury
    Viral Hepatitis
    Monogenetic Liver Diseases
    Biliary Disease
    Experimental Hepatocarcinogenesis
    Physiopathology of hepatocellular carcinoma
    Biology of Normal Joint and Evaluation of the Joint Including Clinical, Imaging and Pathologic Evaluation
    The Pathobiology of Osteoarthritis
    Crystal Diseases
    Inflamatory-Juvenile Idiopathic Arthritis
    Nodular Fasciitis
    Superficial fibromatoses
    Desmoid fibromatosis
    Targeting Oncogenic Pathways in Dermatofibrosarcoma Protuberans and Inflammatory Myofibroblastic Tumor
    Adipocytes in normal tissue biology
    Parkinson’s disease
    Amyotrophic lateral sclerosis and other Motor neuron diseases
    Human Prion Diseases
    Corneal pathologies
    Lens: structure / function and pathologies
    Outer retinal degenerations genetic and non-genetic
    Optic nerve structure and pathologies
    Hyaloid vasculature: structure and pathologies
    Retinal vasculature: structure and pathologies
    Outer retinal vasculature structure and choroidopathies
    Ocular tumors
    The eyelid: structure, function and pathology
    Normal Pancreatic Development
    Anatomy, Histology and Function of the Pancreas
    Pancreatic Cancer and its Precursor Lesions
    Altered Signaling Pathways and Potential Therapeutic Targets in Pancreatic Cancer
    Cell of Origin and Mouse Models for Pancreatic Cancer
    Neuroendocrine Tumors of the Pancreas
    Normal structure and function of the placenta
    Human Placental development from conception to term
    Placental vasculogeneis/angiogenesis
    Embryonic and fetal red blood cell development
    Overview of Human Implantation
    (B) The immunology of the placenta
    Placental pathologies – intrauterine infections
    Chronic Inflammatory Entities of the Placenta
    Pathologic Effects of Maternal Hypertension and Defective Placentation on Placental Growth and Development
    The Placenta in Obesity and Diabetes Mellitus
    Placental Pathologies-Miscellaneous
    Mammalian placentation and implications for animal models
    Gestational trophoblastic disease
    Neuroendocrine Prostate Cancer
    Testicular Anatomy and Physiology
    Non-Neoplastic Disorders of the Testes
    Testicular Tumors
    Semen Analysis, Male Infertility, and Male Contraception
    Psychobiology of Autism
    Obsessive Compulsive Disorder
    Use of Functional Connectivity to Identify Brain Circuits Involved in Psychopathology
    Introductory anatomy, histology and cell biology of the lung
    Cell death and repair in lung disease
    Pulmonary Development and Pediatric Lung Diseases
    Pulmonary hypertension/ Pulmonary arterial hypertension
    Pulmonary fibrosis
    Pathogenesis and Mechanisms of Asbestosis and Silicosis
    Pathobiology of the Acute Respiratory Distress Syndrome
    Thoracic Neoplasia-Carcinoma
    Thoracic Neoplasia-Mesothelioma
    Normal urinary tract development and anomalies
    Normal kidney function
    Glomerular disease
    Mesangiopathies: IgA Nephropathy
    Immune mediated glomerular injury
    Antibody mediated glomerular injury
    Complement mediated
    Metabolic glomerular injury
    Monoclonal gammopathies (glomerular & tubular injuries)
    Tubulointerstitial diseases
    Infectious diseases - HIV, HEP B, C, BK and other viruses
    Renal tumors to include Wilms
    Bladder tumors
    "Infectious Diseases - Urinary Tract Infections (bacterial) "
    Normal Vascular Structure and Function
    Modes of neovascularization in tumors and clinical translation of antiangiogenic therapy
    Vascular Aneurysms and Dissections
    Vascular Tumors
    Use of human biospecimens for research
    Regulatory aspects of biospecimen collection and distribution
    Biorepository operations and infrastructure
    Clinical annotation and data management
    Biorepository Quality Assurance
    Biorepository Management and Cost Structure
    The RBC as a Physiological Object in the Circulation
    The Red Blood Cell as a Target of Damage
    Red Blood Cell Storage
    The Therapeutic Use of Red Blood Cells
    The Platelet as a Multifunctional Cell in the Circulation
    The Platelet as a Target of Damage
    Platelet Storage
    Plasma Components as Targets of Damage
    Plasma Component Storage
    The Therapeutic Use of Plasma Components and Derivatives
    Complications of Transfusion
    Assay Development
    Assay Principles
    Test Interpretation
    Molecular Diagnostics
    Introduction to Cytogenetics
    Introduction to Basic Cytologic Diagnosis
    Cervical Cytology (The Pap Test)
    Non-Gynecologic Fluid and Brushing Cytology
    Fine Needle Aspiration Cytology
    Gene/Genome Mutation Scanning and Testing
    The Human Genome Project and Personalized Medicine
    What is Postmortem Pathology: The Why and How We Do It
    Recent Contributions of Post-mortem Pathology to the Public
    Toxicology in Post-mortem Pathology
    The Negative Autopsy
    Radiology, Forensic Imaging and the "virtual autopsy"
    Genetics and the Molecular Autopsy
    General Approaches in Surgical Pathology
    Surgical Pathology of Inflammatory Conditions of the GI Tract
    Surgical Pathology of Malignant Neoplasms
    Surgical Pathology of Carcinomas
    Surgical Pathology of Sarcomas
    Surgical Pathology of Melanocytic Neoplasms
    Surgical Pathology of Neoplasms of the Central Nervous System
    Surgical Pathology of Hematopoietic Neoplasms
    Historical Roots of Flow Cytometry
    Hardware: The Flow Cytometer
    Flow Cytometry Software
    Digital Imaging Fundamentals
    Image analysis
    Applications of Image Science to Diagnostic Pathology
    Enzyme Histochemistry
    History of Immunohistochemistry
    Fixation and Tissue Processing
    Immunohistochemistry: Antibody Specificity
    Antigen Retrieval Techniques
    IHC Detection Methods
    Detection of Apoptosis and Autophagy
    Optical coherence tomography
    Confocal endomicroscopy
    Photoacoustic imaging
    Diffuse optical imaging
    Molecular imaging
    Intravital microscopy
    CT applications for radiation treatment of cancers
    Magnetic Resonance Imaging
    Cardiac imaging
    Nucleic acid extraction
    In vitro amplification techniques
    In situ techniques
    Quality Assurance
    Circulating Tumor Cells
    Next Generation
    How do Bioinformatics Approaches Apply to the Analysis and Understanding of Disease Pathology?
    Aplastic Anemia
    Paroxysmal nocturnal hemoglobinuria
    Disorders of iron metabolism: iron deficiency and iron overload and anemia of chronic diseases
    Heme biosynthesis and its disorders: porphyrias and sideroblastic anemias
    Megaloblastic anemias
    Hemoglobinopathies and thalassemia syndromes
    Hemolytic anemias
    Normal coagulation and hemostasis
    Platelet disorders
    Congenital coagulopathies
    Acquired coagulopathies
    Disorders of coagulation in the neonate
    Thrombotic thrombocytopenic purpura and the hemolytic uremic syndrome
    Antithrombotic drugs and their complications

Product details

  • No. of pages: 5000
  • Language: English
  • Copyright: © Academic Press 2014
  • Published: August 1, 2014
  • Imprint: Academic Press
  • eBook ISBN: 9780123864574

About the Editors in Chief

Linda McManus

Affiliations and Expertise

Professor, Department of Pathology, University of Texas Health Science Center, Co-Director, Translational Science Training (TST) Across Disciplines Program, San Antonio, USA

Richard Mitchell

Richard N Mitchell, MD, PhD, Lawrence J. Henderson Professor of Pathology and Health Sciences and Technology, Department of Pathology, Harvard Medical School, Staff Pathologist, Brigham and Women's Hospital, Boston, Massachusetts

Affiliations and Expertise

Lawrence J. Henderson Professor of Pathology and Health Sciences and Technology, Department of Pathology, Harvard Medical School, Staff Pathologist, Brigham and Women's Hospital, Boston, Massachusetts

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