Pathobiology of Cell Membranes

Pathobiology of Cell Membranes

Volume II

1st Edition - January 1, 1980

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  • Editors: Benjamin F. Trump, Antti U. Arstila
  • eBook ISBN: 9781483276076

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Description

Pathobiology of Cell Membranes, Volume II, is the second in a multivolume treatise on pathobiological aspects of cell membranes that aims to give the reader an overview of developments concerning the role of altered cell membranes in various pathological processes. This volume includes not only information on pathobiological aspects of cell membranes as studied at the molecular and subcellular level but also important new advances in the role of membranes in human diseases such as multiple sclerosis, shock lung, muscle dystrophies, and hematological disorders. The book begins by discussing a very important and yet poorly known aspect of cellular metabolism; namely, the compartmentalization of intracellular cations such as sodium, calcium, and magnesium. This is followed by separate chapters on fundamentals of membrane conformational changes in the erythrocyte model; the structure and function of peroxisomes and their role in disease processes; the use of invertebrate models for studies of pathological reactions; and reactions of lysosomes to cellular injury. Subsequent chapters deal with the pathology of skeletal muscle membranes; the shock lung syndrome; cellular mechanisms involved in jaundice and cholestasis; and pathology of the endothelium.

Table of Contents


  • List of Contributors

    Preface

    Contents of Volume I

    Robert Inslee Weed (1928-1976)

    Chapter I Cell Membrane Cation Localization by Pyroantimonate Methods: Correlation with Cell Function

    I. Introduction

    II. Membrane-Associated Antimonate-Precipitable Cations in Different Cell Types

    III. Alteration in Membrane Cations in Response to Physiological and Pathological Stimuli

    IV. Interpretations and Conclusions

    References

    Editors' Summary to Chapter I

    Chapter II Red Cell Membrane Pathology

    I. Introduction

    II. Ultrastructure and Chemical Composition of Normal Membranes

    III. Reversible Alterations

    IV. Progression of Reversible to Irreversible Alterations

    V. Pathological States

    References

    Editors' Summary to Chapter II

    Chapter III Functions and Alterations of Cell Membranes during Active Virus Infection

    I. Introduction

    II. Investigation of Viral Membrane Constituents

    III. Membrane Dynamics Relating to Virus Infection

    IV. Virus Uptake and Penetration of Cytomembrane Barriers

    V. Membrane-Dependent Steps in Virus Maturation

    VI. The Nuclear Envelope in Virus Infection

    VII. Membrane-Related Cell Reactions

    References

    Editors' Summary to Chapter III

    Chapter IV Structure and Function of Peroxisomes and Their Role in Disease Processes

    I. Introduction

    II. Orthology of Peroxisomes

    III. Peroxisomal Topography

    IV. Biogenesis of Peroxisomes

    V. Breakdown of Peroxisomes

    VI. Morphological Alterations in Peroxisomes

    VII. Alterations in Peroxisomal Single Volume

    VIII. Proliferation and Hyperplasia of Peroxisomes

    IX. Hypoplasia of Peroxisomes

    X. Peroxisomes and Diseases

    XI. Peroxisomal Reaction Patterns during Cell Injury

    XII. Peroxisomes and Tumors

    XIII. Appendix

    References

    Editors' Summary to Chapter IV

    Chapter V Organelle Turnover

    I. Introduction—The Topological Problem Posed by Autophagy

    II. Insects as Experimental Material—the Precision and Synchrony of Changes in Calpodes

    III. Autophagy of Larval Organelles in the Fat Body

    IV. Autophagy in Other Tissues

    V. Plasma Membrane Turnover and the Apical Multivesicular Bodies

    VI. Discussion and Conclusion

    References

    Editors' Summary to Chapter V

    Chapter VI Reactions of Lysosomes to Cell Injury

    I. Introduction and Definitions

    II. Injury to Lysosomes

    III. Responses of Lysosomes

    IV. Summary

    References

    Editors' Summary to Chapter VI

    Chapter VII Pathology of Skeletal Muscle Membranes

    I. Introduction

    II. Pathological and Clinical Studies of Muscle Diseases

    III. Pathology of Specific Membrane Systems

    IV. Muscle Regeneration

    V. Concluding Remarks

    References

    Editors' Summary to Chapter VII

    Chapter VIII The Alveolar Wall in the Shock Lung

    I. Introduction

    II. The Alveolar Wall as a Biological Membrane

    III. Maintenance of Alveolar Structure

    IV. Perfusion

    V. The Syndrome

    VI. Morphology

    VII. Blood Cells

    VIII. Sieving, a Uniform Response

    IX. Correlation of Changes in Structure and Function

    X. Conclusions

    References

    Editors' Summary to Chapter VIII

    Chapter IX Pathology of Jaundice and Cholestasis at the Ultrastructural Level

    I. Bilirubin Metabolism, Bile Excretion, and the Related Fine Structure of the Liver

    II. Constitutional Hyperbilirubinemia

    III. Cholestatis

    References

    Editors' Summary to Chapter IX

    Chapter X Pathology of the Endothelium

    I. Introduction

    II. Morphology of Normal Endothelium

    III. Endothelial Responses to Injury

    IV. Morphological Changes in Endothelium Produced by Endogenous or Exogenous Agents

    V. Immunological Injury

    VI. Endothelial Cell Inclusions

    VII. Morphogenesis and Reactivity of the Regenerating Endothelium

    References

    Editors' Summary to Chapter X

    Index

Product details

  • No. of pages: 496
  • Language: English
  • Copyright: © Academic Press 1980
  • Published: January 1, 1980
  • Imprint: Academic Press
  • eBook ISBN: 9781483276076

About the Editors

Benjamin F. Trump

Affiliations and Expertise

SCHOOL OF MEDICINE UNIVERSITY OF MARYLAND

Antti U. Arstila

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