Pathobiology of Cell Membranes

Pathobiology of Cell Membranes

Volume I

1st Edition - January 1, 1975

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  • Editors: Benjamin F. Trump, Antti U. Arstila
  • eBook ISBN: 9781483276144

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Pathobiology of Cell Membranes, Volume I, represents the first in a multivolume treatise designed for pathologists and cell biologists interested in the role of membrane alterations in disease processes. The treatise will emphasize concepts related to membrane alterations in cell injury as well as methods for elucidating such changes. The book begins with a discussion of the general conceptual aspects of cell injury and some details about the role of membrane alterations in the pathogenesis of both lethal and sublethal cellular reactions. This is followed by separate chapters on applications of circular dichroism to the study of membranes; a cell injury mechanism involving membrane components at the molecular level; and fundamental aspects of cell volume regulation and the modification of this regulation by primary or secondary damage of the cell membrane. Subsequent chapters deal with comparative roles of lysosomal and other membrane damage in cell injury; the role of membrane movements and various types of lysosome formation; toxic effects on mitochondrial membranes; and the concept of a biological membrane in health and disease at the tissue level.

Table of Contents

  • List of Contributors


    Chapter I Cell Membranes and Disease Processes

    I. Introduction

    II. Cell Injury and Disease Processes: Definitions

    III. Normal Cell Membranes: Topography and Nomenclature

    IV. Membrane Structure and Function in Cell Injury


    Chapter II The Use of Circular Dichroism in the Study of the Structure of Cell Membranes

    I. Introduction

    II. Basic Principles

    III. Optically Active Chromophores

    IV. Illustrative Examples of the Use of Circular Dichroism in the Study of Proteins

    V. The Use of Circular Dichroism in Studies of Cell Membranes


    Editors' Summary to Chapter II

    Chapter III Lipid Peroxidation and Fluorescent Molecular Damage to Membranes

    I. Introduction

    II. Chemical Process of Lipid Peroxidation

    III. Free Radical Damage to Enzymes and Other Proteins

    IV. Damage to Membranes and Subcellular Organelles

    V. Fluorescent Molecular Damage and Lipofuscin Pigments


    Editors' Summary to Chapter III

    Chapter IV Colloid Osmotic Pressure as a Cause of Pathological Swelling of Cells

    I. Cloudy Swelling

    II. The Behavior of Isolated Cells

    III. The Status of Cells as Osmometers

    IV. Cells as Oncometers

    V. Cells Behaving as Osmometers without Being Osmometers

    VI. The Problem of Respiring Cells

    VII. Pathological Swelling of Cells

    VIII. Summary


    Editors' Summary to Chapter IV

    Chapter V Photopathology of the Erythrocyte Membrane

    I. Introduction

    II. Nature of the Ultraviolet Lesion

    III. The Mechanism of Lysis

    IV. Addendum


    Editors' Summary to Chapter V

    Chapter VI Alterations in Lysosomal Membranes as Related to Disease Processes

    I. Introductory Review

    II. Methods of Demonstration of Alterations in Lysosomal Membranes

    III. Lysosomal Labilizers and Stabilizers

    IV. Lysosomes in Cell Injury

    V. Role of Endocytosis in the Extracellular Release of Lysosomal Enzymes


    Editors' Summary to Chapter VI

    Chapter VII The Endocytic Uptake of Macromolecules

    I. Introduction

    II. Endocytosis

    III. Postengulfment Events

    IV. Endocytosis of Macromolecules in Physiology and Pathology


    Editors' Summary to Chapter VII

    Chapter VIII The Cellular Mechanisms of Hormonally Induced Tissue Atrophy

    I. Introduction

    II. Mechanism of Cell Injury and Cell Death in Hormonally Induced Atrophy

    III. Degradation of Cell Components by Autophagy

    IV. Mechanisms of Macromolecular Degradation

    V. Degradation of Tissue Components by Heterophagy in Macrophages

    VI. General Summary


    Editors' Summary to Chapter VIII

    Chapter IX Thyroid Lysosomes in Health and Disease

    I. Introduction

    II. The Normal Gland

    III. Experimental Studies

    IV. Biochemical Effects of TSH Related to Endocytosis of Thyroglobulin

    V. Clinical Pathology

    VI. Conclusion


    Editors' Summary to Chapter IX

    Chapter X Toxic Changes in Mitochondrial Membranes and Mitochondrial Function

    I. Introduction

    II. Lead

    III. Mercury

    IV. Effects of Other Metals on Mitochondria

    V. Effects of Antibiotics in Mitochondrial Membranes

    VI. Ethanol

    VII. Pesticides

    VIII. Oxygen Toxicity

    IX. Mechanism of Action of Uncouplers of Oxidative Phosphorylation

    X. Summary


    Editors' Summary to Chapter X

    Chapter XI Human Intestinal Epithelium as a Biological Membrane

    I. Introduction

    II. Normal Membrane Structure of the Intestinal Absorptive Cell

    III. Capillary, Lymphatic, and Epithelial Permeability of the Intestinal Mucosa

    IV. Pathologic Alterations of the Intestinal Epithelium and Malabsorption


    Editors' Summary to Chapter XI

    Author Index

    Subject Index

Product details

  • No. of pages: 514
  • Language: English
  • Copyright: © Academic Press 1975
  • Published: January 1, 1975
  • Imprint: Academic Press
  • eBook ISBN: 9781483276144

About the Editors

Benjamin F. Trump

Affiliations and Expertise


Antti U. Arstila

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