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Pathobiology of Cell Membranes - 1st Edition - ISBN: 9780127015019, 9781483276144

Pathobiology of Cell Membranes

1st Edition

Volume I

Editors: Benjamin F. Trump Antti U. Arstila
eBook ISBN: 9781483276144
Imprint: Academic Press
Published Date: 1st January 1975
Page Count: 514
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Pathobiology of Cell Membranes, Volume I, represents the first in a multivolume treatise designed for pathologists and cell biologists interested in the role of membrane alterations in disease processes. The treatise will emphasize concepts related to membrane alterations in cell injury as well as methods for elucidating such changes. The book begins with a discussion of the general conceptual aspects of cell injury and some details about the role of membrane alterations in the pathogenesis of both lethal and sublethal cellular reactions. This is followed by separate chapters on applications of circular dichroism to the study of membranes; a cell injury mechanism involving membrane components at the molecular level; and fundamental aspects of cell volume regulation and the modification of this regulation by primary or secondary damage of the cell membrane. Subsequent chapters deal with comparative roles of lysosomal and other membrane damage in cell injury; the role of membrane movements and various types of lysosome formation; toxic effects on mitochondrial membranes; and the concept of a biological membrane in health and disease at the tissue level.

Table of Contents

List of Contributors


Chapter I Cell Membranes and Disease Processes

I. Introduction

II. Cell Injury and Disease Processes: Definitions

III. Normal Cell Membranes: Topography and Nomenclature

IV. Membrane Structure and Function in Cell Injury


Chapter II The Use of Circular Dichroism in the Study of the Structure of Cell Membranes

I. Introduction

II. Basic Principles

III. Optically Active Chromophores

IV. Illustrative Examples of the Use of Circular Dichroism in the Study of Proteins

V. The Use of Circular Dichroism in Studies of Cell Membranes


Editors' Summary to Chapter II

Chapter III Lipid Peroxidation and Fluorescent Molecular Damage to Membranes

I. Introduction

II. Chemical Process of Lipid Peroxidation

III. Free Radical Damage to Enzymes and Other Proteins

IV. Damage to Membranes and Subcellular Organelles

V. Fluorescent Molecular Damage and Lipofuscin Pigments


Editors' Summary to Chapter III

Chapter IV Colloid Osmotic Pressure as a Cause of Pathological Swelling of Cells

I. Cloudy Swelling

II. The Behavior of Isolated Cells

III. The Status of Cells as Osmometers

IV. Cells as Oncometers

V. Cells Behaving as Osmometers without Being Osmometers

VI. The Problem of Respiring Cells

VII. Pathological Swelling of Cells

VIII. Summary


Editors' Summary to Chapter IV

Chapter V Photopathology of the Erythrocyte Membrane

I. Introduction

II. Nature of the Ultraviolet Lesion

III. The Mechanism of Lysis

IV. Addendum


Editors' Summary to Chapter V

Chapter VI Alterations in Lysosomal Membranes as Related to Disease Processes

I. Introductory Review

II. Methods of Demonstration of Alterations in Lysosomal Membranes

III. Lysosomal Labilizers and Stabilizers

IV. Lysosomes in Cell Injury

V. Role of Endocytosis in the Extracellular Release of Lysosomal Enzymes


Editors' Summary to Chapter VI

Chapter VII The Endocytic Uptake of Macromolecules

I. Introduction

II. Endocytosis

III. Postengulfment Events

IV. Endocytosis of Macromolecules in Physiology and Pathology


Editors' Summary to Chapter VII

Chapter VIII The Cellular Mechanisms of Hormonally Induced Tissue Atrophy

I. Introduction

II. Mechanism of Cell Injury and Cell Death in Hormonally Induced Atrophy

III. Degradation of Cell Components by Autophagy

IV. Mechanisms of Macromolecular Degradation

V. Degradation of Tissue Components by Heterophagy in Macrophages

VI. General Summary


Editors' Summary to Chapter VIII

Chapter IX Thyroid Lysosomes in Health and Disease

I. Introduction

II. The Normal Gland

III. Experimental Studies

IV. Biochemical Effects of TSH Related to Endocytosis of Thyroglobulin

V. Clinical Pathology

VI. Conclusion


Editors' Summary to Chapter IX

Chapter X Toxic Changes in Mitochondrial Membranes and Mitochondrial Function

I. Introduction

II. Lead

III. Mercury

IV. Effects of Other Metals on Mitochondria

V. Effects of Antibiotics in Mitochondrial Membranes

VI. Ethanol

VII. Pesticides

VIII. Oxygen Toxicity

IX. Mechanism of Action of Uncouplers of Oxidative Phosphorylation

X. Summary


Editors' Summary to Chapter X

Chapter XI Human Intestinal Epithelium as a Biological Membrane

I. Introduction

II. Normal Membrane Structure of the Intestinal Absorptive Cell

III. Capillary, Lymphatic, and Epithelial Permeability of the Intestinal Mucosa

IV. Pathologic Alterations of the Intestinal Epithelium and Malabsorption


Editors' Summary to Chapter XI

Author Index

Subject Index


No. of pages:
© Academic Press 1975
1st January 1975
Academic Press
eBook ISBN:

About the Editors

Benjamin F. Trump

Affiliations and Expertise


Antti U. Arstila

Ratings and Reviews