Pathobiology of Alzheimer's Disease - 1st Edition - ISBN: 9780122869655, 9780080538495

Pathobiology of Alzheimer's Disease

1st Edition

Series Volume Editors: Alison Goate Frank Ashall
Series Editors: Peter Jenner
Hardcover ISBN: 9780122869655
eBook ISBN: 9780080538495
Imprint: Academic Press
Published Date: 17th October 1995
Page Count: 256
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Table of Contents

Alzheimer's Disease. An Historical and Scientific Overview. Biochemistry and Ultrastructure of Paired Helical Filaments. Tau and Its Significance for Alzheimer's Disease. Mutations in the APP Gene in Alzheimer's Disease. Transcriptional Control of APP Expression. Post-Translational (Non-Proteolytic) Modification of APP. Proteolytic Processing of APP. Neurotoxicity of B-Amyloid and APP. Biological Functions of APP. Animal Models of Alzheimer's Disease. Relation of Plaques and Tangles to Alzheimer's Disease Phenotype. Apolipoprotein E and Alzheimer's Disease. Subject Index.


Description

Alzheimer's Disease. An Historical and Scientific Overview. Biochemistry and Ultrastructure of Paired Helical Filaments. Tau and Its Significance for Alzheimer's Disease. Mutations in the APP Gene in Alzheimer's Disease. Transcriptional Control of APP Expression. Post-Translational (Non-Proteolytic) Modification of APP. Proteolytic Processing of APP. Neurotoxicity of B-Amyloid and APP. Biological Functions of APP. Animal Models of Alzheimer's Disease. Relation of Plaques and Tangles to Alzheimer's Disease Phenotype. Apolipoprotein E and Alzheimer's Disease. Subject Index.

Key Features

  • Reviews the current knowledge of the pathogenesis of Alzheimer's Disease from a clinical perspective to a genetic and cell biological perspective
  • A comprehensive description of the role of amyloid B-protein precursor in Alzheimer's disease.
  • Up-to-date research data
  • Clear illustrations complement the text

Details

No. of pages:
256
Language:
English
Copyright:
© Academic Press 1995
Published:
Imprint:
Academic Press
eBook ISBN:
9780080538495
Hardcover ISBN:
9780122869655

About the Series Volume Editors

Alison Goate Series Volume Editor

Affiliations and Expertise

St. Louis University School of Medicine, Missouri, U.S.A.

Frank Ashall Series Volume Editor

Affiliations and Expertise

St. Louis University School of Medicine, Missouri, U.S.A.

About the Series Editors

Peter Jenner Series Editor

Affiliations and Expertise

King's College, London, U.K. Head of Pharmacology and Therapeutics Division