Patent Foramen Ovale Closure for Stroke, Myocardial Infarction, Peripheral Embolism, Migraine, and Hypoxemia - 1st Edition - ISBN: 9780128169667

Patent Foramen Ovale Closure for Stroke, Myocardial Infarction, Peripheral Embolism, Migraine, and Hypoxemia

1st Edition

Editors: M. Khalid Mojadidi Bernhard Meier Jonathan M. Tobis
Paperback ISBN: 9780128169667
Imprint: Academic Press
Published Date: 6th September 2019
Page Count: 254
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Patent Foramen Ovale (PFO) Closure for Stroke, Myocardial Infarction, Peripheral Embolism, Migraine, and Hypoxemia is a complete reference covering the association between PFO and numerous medical conditions. It provides a background on the topic including embryology, anatomy, and physiology. This book fully examines the diagnosis and imaging assessment of PFO and discusses the data linking PFO to various clinical pathologies. It details technical aspects of PFO closure and includes perspectives on future outlooks and where the field is headed in terms of device closure indications. This is a complete reference book for cardiologists, interventional cardiologists, neurologists, pulmonologists, general practitioners, medical professionals, and researchers who are interested in PFO-associated pathologies, technical aspects, safety, and future outlooks of PFO device closure.

Key Features

  • Explains the association between PFO and related clinical conditions including stroke, myocardial infarction, peripheral embolism, migraine, hypoxemia, decompression sickness, Raynaud’s phenomenon, and vasospasm
  • Provides an in-depth analysis of the evidence behind PFO closure for various clinical conditions
  • Expounds on the technical aspects of PFO closure including differences between devices and techniques
  • Offers future outlooks on PFO closure and where the field is headed in terms of PFO closure indications


Cardiology researchers, cardiologists, general practitioners and medical professionals that are interested in current technical aspects of the field and in the future outlooks on PFO closure

Table of Contents

1. Embryology, Anatomy, and Physiology: Anatomical Variations, Lipomatous Hypertrophy, Atrial Septal Aneurysm, Eustachian Valve, Chiari Network, Combination With Other Atrial Septal Defects

2. Echocardiography, Transcranial Doppler, and Oximetry for Imaging and Quantification of PFO-Mediated Shunts
3. Angiography, Transthoracic, Transesophageal, and Intracardiac Echocardiography: PeriproceduralAssessment and Guidance During PFO Closure

4. Definition of Cryptogenic Stroke, the Risk of Paradoxical Embolism (RoPE) Score, and Assessment of Embolic Stroke of Undetermined Source
5. Observational Studies of PFO Closure for Stroke
6. Early Randomized Trials of PFO Closure for Stroke (CLOSURE I, PC, RESPECT)
7. Newer Randomized Trials on PFO Closure for Stroke (REDUCE, CLOSE, DEFENSE-PFO)

8. Myocardial Infarction and Patent Foramen Ovale
9. Peripheral Embolism and Patent Foramen Ovale

10. Migraine Headache: Clinical Association With PFO and Observational Studies
11. Randomized Clinical Trials of PFO Closure for Migraine Headache (MIST, PRIMA, PREMIUM)

12. Hypoxemia and Patent Foramen Ovale 13. Less Recognized Conditions Associated With Patent Foramen Ovale: Decompression Illness, Carcinoid Heart Disease, Coronary Spasm

14. Percutaneous Patent Foramen Ovale Closure: History, Devices, Techniques, Safety, and Informed Consent
15. How I Do It: ICE-Guided Technique for Percutaneous PFO Closure
16. How I Do It: Fluoroscopy-Guided Technique for Percutaneous Patent Foramen Ovale Closure
17. Patent Foramen Ovale Closure: History, Final Thoughts, and Future Outlook
18. The Full Spectrum of PFO: Are We Seeing Just the Tip of the Iceberg?
19. Frequently Asked Questions: PFO Closure With the Amplatzer or Gore cardioform Devices
















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© Academic Press 2020
Academic Press
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About the Editor

M. Khalid Mojadidi

Dr. M. Khalid Mojadidi is an invasive Cardiologist affiliated with University of Florida Health- Shands Hospital. He is also an assistant professor at Virginia Commonwealth University. His clinical concentration includes invasive and noninvasive cardiology, echocardiography, and nuclear cardiology. His research interests include PFO and related clinical pathologies. He is a current member of the American Society of Nuclear Cardiology (ASNC), American College of Cardiology (ACC), European Society of Cardiology (ESC), European Association of Preventative Cardiology (EAPC) and the American College of Physicians (ACP). Since early in his career, he has published extensively on different aspects of percutaneous PFO closure for numerous medical conditions and is an active peer reviewer of 12 current journals.

Affiliations and Expertise

Invasive Cardiologist and Assistant Professor, Division of Cardiology, Virginia Commonwealth University, Richmond, VA, United States

Bernhard Meier

Bernhard Meier has served from 1992 to his retirement in 2015 as full Professor of Cardiology and Chairman of the Department of Cardiology at the Swiss Cardiovascular Center Bern of the University of Bern, Switzerland. Since 2016 he has served as Senior Consultant. Meier has been a personal assistant to Andreas Gruentzig, at the time Gruentzig introduced coronary angioplasty into clinical medicine. Hence, he has been involved in the procedure starting from the world’s first coronary angioplasty patient, treated in Zurich on September 16, 1977, to the current day. He has personally performed thousands of coronary angioplasty and other catheter-based cardiac procedures and implanted the world's first dedicated PFO occluder in 1997. Meier has written countless articles, reviews, and book chapters about interventional cardiology. He has also been involved in teaching in this field for 40 years, organizing and conducting dedicated courses and seminars and participating in events around the world.

Affiliations and Expertise

Professor of Cardiology, Senior Consultant and Former Chairman of Cardiology, Department of Cardiology, University Hospital of Bern, Switzerland

Jonathan M. Tobis

Dr. Tobis is the Director of Interventional Cardiology Research at UCLA and Clinical Professor of Medicine in Cardiology at the University of California. He also serves as a Member of the Medical Advisory board of Coherex Medical, Inc. He performed the world’s first digital left ventricular and coronary angiograms and contributed to the advancements of intravascular ultrasound early in his career. He is the winner of several industry awards including the Simon Dack Award from the Journal of the American College of Cardiology; Named Master Fellow of the Society for Cardiovascular Angiography and Interventions (MSCAI), the professional medical society for adult and pediatric invasive/interventional cardiologists; voted one of America's Top Doctors by US News and World Reports, and voted one of the 10 Most Highly Regarded Heart Doctors in the US. His recent work is devoted to understanding the role of PFO closure in relation to several medical conditions including stroke and migraine.

Affiliations and Expertise

Director of Interventional Cardiology Research; Clinical Professor of Medicine, Cardiology, David Geffen School of Medicine, Division of Cardiology, University of California, Los Angeles, CA, USA

Ratings and Reviews