Patent Foramen Ovale Closure for Stroke, Myocardial Infarction, Peripheral Embolism, Migraine, and Hypoxemia

Patent Foramen Ovale Closure for Stroke, Myocardial Infarction, Peripheral Embolism, Migraine, and Hypoxemia

1st Edition - August 23, 2019

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  • Editors: M. Khalid Mojadidi, Bernhard Meier, Jonathan M. Tobis
  • eBook ISBN: 9780128173343
  • Paperback ISBN: 9780128169667

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Patent Foramen Ovale (PFO) Closure for Stroke, Myocardial Infarction, Peripheral Embolism, Migraine, and Hypoxemia is a complete reference covering the association between PFO and numerous medical conditions. It provides a background on the topic including embryology, anatomy, and physiology. This book fully examines the diagnosis and imaging assessment of PFO and discusses the data linking PFO to various clinical pathologies. It details technical aspects of PFO closure and includes perspectives on future outlooks and where the field is headed in terms of device closure indications. This is a complete reference book for cardiologists, interventional cardiologists, neurologists, pulmonologists, general practitioners, medical professionals, and researchers who are interested in PFO-associated pathologies, technical aspects, safety, and future outlooks of PFO device closure.

Key Features

  • Explains the association between PFO and related clinical conditions including stroke, myocardial infarction, peripheral embolism, migraine, hypoxemia, decompression sickness, Raynaud’s phenomenon, and vasospasm
  • Provides an in-depth analysis of the evidence behind PFO closure for various clinical conditions
  • Expounds on the technical aspects of PFO closure including differences between devices and techniques
  • Offers future outlooks on PFO closure and where the field is headed in terms of PFO closure indications


Cardiology researchers, cardiologists, general practitioners and medical professionals that are interested in current technical aspects of the field and in the future outlooks on PFO closure

Table of Contents

    1. Embryology, Anatomy, and Physiology: Anatomical Variations, Lipomatous Hypertrophy, Atrial Septal Aneurysm, Eustachian Valve, Chiari Network, Combination With Other Atrial Septal Defects

    2. Echocardiography, Transcranial Doppler, and Oximetry for Imaging and Quantification of PFO-Mediated Shunts
    3. Angiography, Transthoracic, Transesophageal, and Intracardiac Echocardiography: Periprocedural Assessment and Guidance During PFO Closure

    4. Definition of Cryptogenic Stroke, the Risk of Paradoxical Embolism RoPE Score, and Assessment of Embolic Stroke of Undetermined Source
    5. Observational Studies of PFO Closure for Stroke
    6. Early Randomized Trials of PFO Closure for Stroke (CLOSURE I, PC, RESPECT)
    7. Newer Randomized Trials on PFO Closure for Stroke (CLOSE, REDUCE, and DEFENSE-PFO)

    8. Myocardial Infarction and PFO
    9. Peripheral Embolism and PFO

    10. Migraine Headache: Clinical Association With PFO and Observational Studies
    11. Randomized Clinical Trials of PFO Closure for Migraine Headache (MIST, PRIMA, PREMIUM)

    12. Hypoxemia and PFO
    13. Less Recognized Conditions Associated with PFO: Decompression Illness, Carcinoid Heart Disease, Coronary Spasm

    14. Percutaneous PFO Closure: History, Devices, Techniques, Safety, and Informed Consent
    15. How I Do It: ICE-guided Technique for Percutaneous PFO Closure
    16. How I Do It: Fluoroscopy-guided Technique for Percutaneous PFO Closure
    17. PFO Closure: History, Final thoughts and Future outlook
    18. The Full Spectrum of PFO: Are We Seeing Just the Tip of the Iceberg?
    19. Frequent Questions: PFO Closure With the Amplatzer or Gore Cardioform Devices

Product details

  • No. of pages: 254
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: August 23, 2019
  • Imprint: Academic Press
  • eBook ISBN: 9780128173343
  • Paperback ISBN: 9780128169667

About the Editors

M. Khalid Mojadidi

Dr. M. Khalid Mojadidi is an Invasive Cardiologist and Assistant Professor of Medicine at Virginia Commonwealth University. His clinical concentration includes invasive and noninvasive cardiology, echocardiography, and nuclear cardiology. His research interests include PFO and related clinical pathologies. Since early in his career, he has published extensively on different aspects of percutaneous PFO closure for numerous medical conditions.

Affiliations and Expertise

Invasive Cardiologist and Assistant Professor, Division of Cardiology, Virginia Commonwealth University, Richmond, VA, United States

Bernhard Meier

Bernhard Meier has served from 1992 to his retirement in 2015 as full Professor of Cardiology and Chairman of the Department of Cardiology at the Swiss Cardiovascular Center Bern of the University of Bern, Switzerland. Since 2016, he served as a Senior Consultant. He has personally performed thousands of coronary angioplasties, starting with assisting on the world’s first case in 1977, and other catheter-based cardiac procedures. He implanted the world’s first dedicated PFO occluder in 1997.

Affiliations and Expertise

Professor of Cardiology, Senior Consultant and Former Chairman of Cardiology, Department of Cardiology, University Hospital of Bern, Switzerland

Jonathan M. Tobis

Dr. Jonathan M. Tobis is the Director of Interventional Cardiology Research at UCLA and Clinical Professor of Medicine in Cardiology at the University of California, Los Angeles. He performed the world’s first digital left ventricular and coronary angiograms and contributed to the advancements of intravascular ultrasound early in his career. His recent work is devoted to understanding the role of PFO closure in relation to several medical conditions including stroke and migraine. He was voted one of the 10 Most Highly Regarded Heart Doctors in the United States.

Affiliations and Expertise

Director of Interventional Cardiology Research; Clinical Professor of Medicine, Cardiology, David Geffen School of Medicine, Division of Cardiology, University of California, Los Angeles, CA, USA

Ratings and Reviews

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  • Michael K. Thu Nov 28 2019

    MD, Cardiologist

    The most comprehensive book on everything you need to know about PFO closure!

  • Mark P. Wed Sep 04 2019

    MD, Cardiologist

    Superb book on everything you will need to know about PFO closure! Highly recommended.