Particle Separation Techniques
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Particle Separation Techniques

Fundamentals, Instrumentation, and Selected Applications

1st Edition - July 22, 2022

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  • Editor: Catia Contado
  • Paperback ISBN: 9780323854863
  • eBook ISBN: 9780323854870

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Description

Particle Separation Techniques: Fundamentals, Instrumentation, and Selected Applications presents the latest research in the field of particle separation methods. This edited book authored by subject specialists is logically organized in sections, grouping the separation techniques according to their preparative or analytical purposes and the particle type. Along with the traditional and classical separation methods suitable for micronic particles, an update survey of techniques appropriate for nanoparticle characterization is presented. This book fills the gap in the literature of particle suspension analysis of a synthetic but comprehensive manual, helping the reader to identify and apply selected techniques.It provides an overview of the techniques available to a reader who is not an expert on particle separation yet about to enter the field, design an experiment, or buy an instrument for his/her new lab.

Key Features

  • Presents a resource that is ideal for anyone preparing samples across a variety of fields, including pharmaceuticals, food science, pollution analysis and control, agricultural products, and more
  • Includes real case examples discussed by leading experts in the field
  • Provides chapters that contain a unique, common table that summarizes points-of-strength and the weaknesses of each technique

Readership

Academics and laboratory managers in industry and research centers, both in the sample preparation and analytical sectors; fields where highly purified and selected samples are required, e.g. biochemistry. Professional scientists entering or working in a variety of areas including: pharmaceuticals, food science, pollution analysis and control, agricultural products, pigments and chemicals, electronic materials, polymers; instructors in academia who want to teach a specific topic in the field

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Dedication
  • Contributors
  • Part I. Introduction
  • Chapter 1. Introduction
  • 1. Why size matter?
  • 2. Scope of the book
  • 3. Structure of the book
  • 4. Notation and terminology
  • Chapter 2. What is a particle, classification and properties
  • 1. Particle definition
  • 2. Particle classification
  • 3. Particle properties
  • Chapter 3. Particle dispersions in liquid media
  • 1. Introduction and overview
  • 2. Dispersing principles and mechanisms
  • 3. Particle stabilization
  • 4. Case studies for the dispersion of nanoparticles
  • 5. Conclusions
  • Chapter 4. Particle characterization: parameters and selected methods
  • 1. Introduction
  • 2. Parameter selection
  • 3. Techniques
  • 4. Conclusions
  • Part II. Preparative separations
  • Chapter 5. Membrane-based filtration technology
  • 1. Introduction
  • 2. Principle of membrane processes
  • 3. Membrane materials
  • 4. Applications of membrane
  • 5. Conclusion
  • Chapter 6. Sedimentation
  • 1. Introduction
  • 2. Fundamentals
  • 3. Detailed methods and protocols
  • 4. Applications
  • 5. Recent developments
  • 6. Conclusions
  • Chapter 7. Electrophoresis and dielectrophoresis
  • 1. Introduction
  • 2. Fundamentals
  • 3. Detailed methods/protocols
  • 4. Literature review and recent developments
  • 5. Worked examples and modeling
  • 6. Summary and conclusion
  • Chapter 8. Magnetic separations
  • 1. Scope
  • 2. Size matters: magnetic nano-, microparticles, and biological cells
  • 3. Emerging applications of magnetic separation in biomedicine and biotechnology
  • 4. Elements of theory of magnetic microparticle separation
  • 5. Magnetic microfluidic separator design considerations: bio-ferrograph
  • 6. Cell magnetophoretic analysis by cell tracking velocimetry (CTV)
  • 7. Conclusions
  • Chapter 9. Historical overview of flow cytometry and frontier applications
  • 1. Background
  • 2. Background and principles of cell sorting
  • 3. Principles of the measurement and components of cell sorters
  • 4. Fluorescence-based flow cytometry
  • 5. Fundamental advances within modern cell sorting instrumentation
  • 6. Is physical separation necessary to identify a population?
  • 7. Small-particle analysis and separation
  • 8. Spectral flow cytometry and spectral sorting
  • 9. Analysis and sorting of microbes
  • 10. Advanced analytical techniques
  • 11. To sort or not to sort
  • 12. Conclusion
  • Chapter 10. Affinity chromatography
  • 1. Introduction
  • 2. Support materials
  • 3. Immobilization methods
  • 4. Application and elution conditions
  • 5. Applications of affinity chromatography
  • 6. Summary
  • Chapter 11. Affinity separation on fibers and surfaces
  • 1. Introduction
  • 2. Membranes and fibers
  • 3. Monoliths
  • 4. Cryogels
  • 5. Molecular imprinting for macromolecules separation
  • 6. Affinity adsorption for blood purification by extracorporeal apheresis
  • 7. Practical approach
  • 8. Future perspectives
  • Part III. Analytical separations
  • Chapter 12. Production, role and use of reference materials for nanoparticle characterization
  • 1. Definitions
  • 2. Underpinning knowledge (fundamentals)
  • 3. Applications
  • 4. Sources of reference materials
  • 5. Conclusions and outlook
  • Chapter 13. Size exclusion chromatography (SEC)
  • 1. Introduction
  • 2. Fundamentals
  • 3. Analysis of macromolecules
  • 4. Preparative size exclusion chromatography
  • 5. Classification of nanoparticles by SEC
  • 6. Summary
  • Chapter 14. Passive and active microfluidic separation methods
  • 1. Introduction
  • 2. Passive microfluidic techniques
  • 3. Active microfluidic separation devices
  • 4. Conclusions
  • Chapter 15. Inertial microfluidic techniques
  • 1. Introduction
  • 2. Hydrodynamic interactions
  • 3. Inertial effect in laminar flows
  • 4. Inertial effects as potential separation and characterization method
  • 5. Configuration and inertial effect: orders of magnitude
  • 6. Other parameters: finite Reynolds number and particle shape
  • 7. Many particle flow and separation
  • 8. Inertial effects: Orders of magnitude of lift forces
  • 9. Microfluidic separations
  • 10. Conclusions
  • Chapter 16. Analytical ultracentrifugation
  • 1. Introduction
  • 2. Instruments
  • 3. Basic experimental types
  • 4. Sedimentation velocity (SV) experiment
  • 5. Density gradient experiment
  • 6. Applications
  • 7. Pros and cons
  • Chapter 17. Centrifugal liquid sedimentation methods
  • 1. Definitions
  • 2. Underpinning knowledge (fundamentals)
  • 3. Methods and protocols
  • 4. Applications
  • 5. Summary and outlook
  • Chapter 18. Theoretical principles of field-flow fractionation and SPLITT fractionation
  • 1. Introduction to field-flow fractionation
  • 2. Theoretical aspects
  • 3. FFF techniques
  • 4. Introduction to SPLITT fractionation
  • 5. Conclusions
  • Chapter 19. Field flow fractionation (FFF): practical and experimental aspects
  • 1. Introduction
  • 2. Techniques
  • 3. Detector systems
  • 4. Examples of applications
  • 5. Conclusions
  • Chapter 20. Capillary electromigration techniques
  • 1. Introduction
  • 2. Capillary electromigration techniques
  • 3. Nanomaterials
  • 4. Bioparticles
  • 5. Concluding remarks
  • Part IV. Present challenges
  • Chapter 21. Regulatory and technical challenges in the size characterization of nanoparticulate systems
  • 1. Introduction
  • 2. Challenges related to legislation
  • 3. Technical challenges
  • 4. Micro- and nanoplastics–new challenges for particle analytics in legislation and analytical science
  • 5. Outlook
  • Index

Product details

  • No. of pages: 768
  • Language: English
  • Copyright: © Elsevier 2022
  • Published: July 22, 2022
  • Imprint: Elsevier
  • Paperback ISBN: 9780323854863
  • eBook ISBN: 9780323854870

About the Series Volume Editor

Catia Contado

Catia Contado is an associate professor of Analytical Chemistry at the University of Ferrara, where she currently teaches analytical chemistry, analytical techniques for characterizing nano- and micro-structured materials, and quality assurance for pharmaceutical industries. She earned a PhD in analytical and environmental chemistry at the University of Ferrara but she carried out her research at the Water Studies Centre of Monash University (Melbourne, AU) and at the Field Flow Fractionation Research Center of University of Utah (UT, USA). In 2006, as Fulbright Fellow, she worked at the Lerner Research Centre - Cleveland Clinic (OH, USA). Her research interests include the development of analytical methods for the analysis of micro and nanomaterials of natural and industrial origin, contained in pharmaceutical, food and consumer products.

Affiliations and Expertise

Associate Professor of Analytical Chemistry, University of Ferrara, Ferrara, Italy

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