This volume provides a complete guide to advancements made in the understanding of Parkinson’s disease and related neurodegenerative disorders. From information on early research conducted in the 1960’s, to modern clinical views of these diseases, this handbook will give clinicians and neuroscientists a state-of-the-art reference that presents critical appraisals on recent developments in the study of these disorders.

As the world population in developed countries ages, these observations are particularly relevant. Dramatic data on the genetic causes of dominant and recessive forms of hereditary Parkinson’s disease are presented, as well as new knowledge on the differences in the intricate circuitry of basal ganglia in healthy individuals and those afflicted with Parkinson’s.

Clinicians will find this to be a great platform on which to base ongoing investigative approaches and research.

Key Features

* A complete guide to the advances made in the field of neurogenerative disorders, including Parkinson’s
* A comprehensive accounting of the parkinsonian disorders, including pharmacological advances, patient management techniques, and therapeutic strategies
* Critical appraisals of recent developments in the field that further clinical research and foster new investigative approaches


Neurologists and neuroscience research workers

Table of Contents

Section 1: Scientific foundation

Anatomy and physiology of the basal ganglia: relevance to parkinson’s disease and related disorders. Functional neurochemistry of the basal ganglia. Dopamine receptor pharmacology.

Section 2: General aspects of Parkinson's disease

History of Parkinson’s disease. Epidemiology of Parkinson’s disease. Neurochemistry of the basal ganglia in Parkinson’s disease. The neuropathology of parkinsonism. Imaging Parkinson’s disease. Parkinson’s disease: animal models.

Section 3: Clinical aspects

Scales to measure parkinsonism. Motor symptoms in Parkinson’s disease. Autonomic dysfunction in Parkinson’s disease. Sleep in Parkinson syndromes. Sensory symptoms in Parkinson’s disease. Speech disorders in Parkinson’s disease and the effects of pharmacological, surgical and speech treatment with emphasis on Lee Silverman voice treatment. Clinical features, pathophysiology and treatment of dementia associated with Parkinson’s disease. Disorders of mood and affect in Parkinson’s disease. Neurobehavioral disorders in Parkinson’s disease. Early detection of Parkinson’s disease.

Section 4: Etiology

Mitochondria in the etiology of Parkinson’s disease. Iron as a trigger of neurodegeneration in Parkinson’s disease. Oxidative stress and Parkinson’s disease. Neurotrophic factors and Parkinson’s disease. Neuroinflammation and Parkinson’s disease. Excitotoxicity. Protein handling dysfunction in Parkinson’s disease. Programmed cell death in Parkinson’s disease.


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© 2007
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About the editors