Paper-Based Analytical Devices for Chemical Analysis and Diagnostics

Paper-Based Analytical Devices for Chemical Analysis and Diagnostics

1st Edition - October 27, 2021

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  • Editors: William de Araujo, Thiago Paixao
  • Paperback ISBN: 9780128205341
  • eBook ISBN: 9780128205358

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Paper-Based Analytical Devices for Chemical Analysis and Diagnostics is a valuable source of information for those interested in microfluidics, bioanalytical devices, chemical instrumentation/mechanization, in-field analysis, and more. This book provides a critical review of the scientific and technological progress of paper-based devices, as well as future trends in the field of portable paper-based sensors for chemical analysis and diagnostics directly at point of need. It uniquely focuses on the analytical techniques associated with each type of device, providing a practical framework for any researcher to use while learning how to use new types of devices in their work, deciding which ones are best for their needs, developing new devices, or working toward commercialization.

Key Features

  • Reviews the evolution of this area and offers predictions for the future of the field of paper-based analytical devices
  • Explores the analytical techniques used in development of paper-based devices
  • Discusses challenges and shortcomings specific to each type of device, helping users and developers to avoid pitfalls


Researchers, faculty, and graduate students conducting work in the area of paper-based microfluidics or electrochemistry. Industry researchers conducting work in the area of paper-based microfluidics or electrochemistry

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Dedication
  • List of contributors
  • Preface
  • Chapter 1. Introduction remarks for paper-based analytical devices and timeline
  • Abstract
  • 1.1 Introduction
  • References
  • Chapter 2. Chemistry of paper—properties, modification strategies, and uses in bioanalytical chemistry
  • Abstract
  • 2.1 Introduction
  • 2.2 Paper fabrication
  • 2.3 Strategies using the dissolution of cellulose to manufacture sensing inks
  • 2.4 Properties of existing unmodified papers
  • 2.5 Paper modification approaches for chemical sensing
  • 2.6 Thermal treatment of cellulose
  • 2.7 Conclusion
  • Acknowledgments
  • References
  • Chapter 3. Paper-based separation devices
  • Abstract
  • 3.1 Introduction
  • 3.2 Paper-based devices for electrophoretic separations
  • 3.3 Paper-based devices for chromatographic separations
  • 3.4 Conclusions and perspectives
  • Acknowledgments
  • References
  • Chapter 4. Colorimetric paper-based analytical devices
  • Abstract
  • 4.1 Introduction
  • 4.2 Physical aspects of colorimetric detection
  • 4.3 Colorimetric reaction methodology
  • 4.4 Detection and readout system
  • 4.5 Conclusions and perspectives
  • References
  • Chapter 5. Electrochemical paper-based analytical devices
  • Abstract
  • 5.1 Introduction
  • 5.2 Principles of the electrochemical measurements using electrochemical paper-based analytical devices
  • 5.3 Paper standardization and area definition
  • 5.4 The fabrication processes of electrochemical paper-based analytical devices and their applications
  • 5.5 Conclusions and perspectives
  • Acknowledgments
  • References
  • Chapter 6. Surface-enhanced Raman scattering paper-based analytical devices
  • Abstract
  • 6.1 Introduction
  • 6.2 Raman enhancement nanostructures onto paper substrates: characteristics and fabrication methods
  • 6.3 Applications of paper and cellulose-based SERS devices
  • 6.4 Concluding remarks and perspectives
  • 6.5 Acknowledgements
  • References
  • Chapter 7. Chemiluminescence paper-based analytical devices
  • Abstract
  • 7.1 Introduction
  • 7.2 Design and fabrication techniques for chemiluminescence-microfluidic paper-based analytical devices
  • 7.3 Detection of chemiluminescence Signals on microfluidic paper-based analytical devices
  • 7.4 Conclusion
  • Acknowledgments
  • References
  • Chapter 8. Fluorescent paper-based analytical devices
  • Abstract
  • 8.1 Introduction
  • 8.2 Fluorescent materials
  • 8.3 Fluorescent response
  • 8.4 Conclusions
  • References
  • Chapter 9. Electrochemiluminescence paper-based analytical devices
  • Abstract
  • 9.1 Background
  • 9.2 Paper-device fabrication methods
  • 9.3 Fabrication of electrodes onto paper
  • 9.4 Electrochemiluminescence sensing strategies
  • 9.5 Potential control and detection: work toward portable devices
  • 9.6 Integrated devices
  • 9.7 Conclusions and future directions
  • Acknowledgments
  • References
  • Chapter 10. Paper-based immunoassays for mobile healthcare: strategies, challenges, and future applications
  • Abstract
  • 10.1 Clinical value of paper-based immunoassays
  • 10.2 The strategies of paper-based immunoassay for mobile healthcare
  • 10.3 The challenges of paper-based immunoassay approaches for mobile healthcare
  • 10.4 Future applications of paper-based immunoassays for mobile healthcare
  • 10.5 Glossary
  • Acknowledgments
  • References
  • Chapter 11. Conclusions, challenges, and next steps
  • Abstract
  • 11.1 Introduction
  • 11.2 Conclusions
  • Acknowledgments
  • References
  • Index

Product details

  • No. of pages: 298
  • Language: English
  • Copyright: © Elsevier 2021
  • Published: October 27, 2021
  • Imprint: Elsevier
  • Paperback ISBN: 9780128205341
  • eBook ISBN: 9780128205358

About the Editors

William de Araujo

William R. Araujo received both bachelor’s degrees in Chemistry and in Science & Technology from Federal University of ABC (UFABC), Brazil. In 2016, he obtained his PhD at the University of São Paulo (USP), Brazil, with a period in the group of Prof. Joseph Wang (University of California-UCSD), USA, working with electrochemical sensors for forensic applications and the development of wearable electrochemical devices. Dr Araujo was awarded with the best doctoral thesis prize (USP 2016). He carried out two years of postdoctoral research on portable paper-based devices and electrochemical sensors to tackle a wide range of applications. In 2018, he was appointed as Assistant Professor at Institute of Chemistry of the State University of Campinas (UNICAMP), Brazil. He coordinates the research group on Portable Chemical Sensors in this institution, and their fields of interest include chemical sensors and biosensors, electrochemistry and electroanalysis, wearable sensors, paper-based devices, and forensics.

Affiliations and Expertise

Institute of Chemistry of the State University of Campinas, Brazil

Thiago Paixao

Thiago R.L.C. Paixão received a BSc (2001), MSc (2004), and PhD (2007), followed by a postdoctoral fellowship between 2008 and 2009 working with electronic tongue devices at the Institute of Chemistry of the University of São Paulo. He was then appointed as an Assistant Professor at the University Federal of ABC where he stayed for two years. In 2011, he was hired as an assistant professor at the University of São Paulo and promoted to Associate Professor in 2016. In the beginning of 2018, he was nominated as affiliate member of the Brazilian Academy of Science as a young promising researcher. His fields of interest include chemical sensors, paper-based devices, and electronic tongues aiming at forensic and clinical applications.

Affiliations and Expertise

University of Sao Paulo, Brazil

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