
Palladium in Heterocyclic Chemistry
A Guide for the Synthetic Chemist
Description
Key Features
- Contains the most up-to-date developments in this fast-moving field
- Includes 3 new chapters
- Contains material from selected well-respected authors on heterocyclic chemistry
Readership
Table of Contents
Chapter 1: An introduction to palladium catalysis
- 1.1 Oxidative coupling/cyclization
- 1.2 Cross-coupling reactions with organometallic reagents
- 1.3 The Sonogashira reaction
- 1.4 The Heck, intramolecular Heck, and heteroaryl Heck reactions
- 1.5 Carbonylation reactions
- 1.6 The Pd-catalyzed C–P bond formation
- 1.7 Palladium-catalyzed C–N bond and C–O bond-forming reactions
- 1.8 The Tsuji–Trost reaction
- 1.9 The Wacker-type reactions
- 1.10 Mori–Ban, Hegedus, and Larock indole syntheses
Chapter 2: Pyrroles
- 2.1 Synthesis of pyrrolyl halides
- 2.2 Oxidative coupling/cyclization
- 2.3 Coupling reactions with organometallic reagents
- 2.4 Sonogashira reaction
- 2.5 Heck and intramolecular Heck reactions
- 2.6 Carbonylation
- 2.7 C-N bond formation reactions
- 2.8 Miscellaneous
Chapter 3: Indoles
- 3.1 Synthesis of indolyl halides
- 3.2 Oxidative coupling/cyclization
- 3.3 Coupling reactions with organometallic reagents
- 3.4 The Sonogashira coupling
- 3.5 Heck couplings
- 3.6 Carbonylation
- 3.7 C–N bond formation reactions
- 3.8 Miscellaneous
Chapter 4: Pyridines
- 4.1 Synthesis of halopyridines
- 4.2 Coupling reactions with organometallic reagents
- 4.3 Sonogashira reaction
- 4.4 Heck and intramolecular Heck reactions
- 4.5 Buchwald–Hartwig aminations(C–N bond formation)
- 4.6 Direct C–C bond formation
- 4.7 Summary
Chapter 5: Thiophenes and benzo[b]thiophenes
- 5.1 Preparation of halothiophenes and halobenzothiophenes
- 5.2 Oxidative and reductive coupling reactions
- 5.3 Cross-coupling with organometallic reagents
- 5.4 Sonogashira reaction
- 5.5 Heck and intramolecular Heck reactions
- 5.6 Carbonylation reactions
- 5.7 Buchwald–Hartwig aminations
- 5.8 Miscellaneous
Chapter 6: Furans and benzo[b]furans
- 6.1 Synthesis of halofurans and halobenzo[b]furans
- 6.2 Oxidative coupling/cyclization
- 6.3 Coupling reactions with organometallic reagents
- 6.4 Sonogashira reaction
- 6.5 Heck, intramolecular Heck, and heteroaryl Heck reactions
- 6.6 Heteroannulation
- 6.7 Carbonylation and C—N and C—O bond formation
Chapter 7: Thiazoles and benzothiazoles
- 7.1 Synthesis of halothiazoles
- 7.2 Coupling reactions with organometallic reagents
- 7.3 Sonogashira reaction
- 7.4 Heck and heteroaryl Heck reactions
- 7.5 Carbonylation
- 7.6 C–N bond formation
- 7.7 Site selective coupling reactions
Chapter 8: Oxazoles and benzoxazoles
- 8.1 Introduction
- 8.2 Synthesis of halooxazoles and halobenzoxazoles
- 8.3 Coupling reactions with organometallic reagents
- 8.4 Heck and heteroaryl Heck reactions
- 8.5 Carbonylation
- 8.6 Palladium-catalyzed amination
- 8.7 Carbopalladation of nitriles
- 8.8 Quaterfuran and Quinquifuran
- 8.9 Summary
Chapter 9: Imidazoles
- 9.1 Synthesis of haloimidazoles
- 9.2 Homocoupling reaction
- 9.3 Coupling reactions with organometallic reagents
- 9.4 Sonogashira reaction
- 9.5 Heck and heteroaryl Heck reactions
- 9.6 Tsuji-Trost reaction
- 9.7 Phosphonylation
Chapter 10: Pyrazines and quinoxalines
- 10.1 Pyrazines
- 10.2 Coupling reactions with organometallic reagents
- 10.3 Palladium-catalyzed amination
- 10.4 Heck reaction
- 10.5 Carbonylation reactions
- 10.6 Cyanation of pyrazines
- 10.7 Deoxygenation of heteroamine-N-oxide
- 10.8 Quinoxalines
Chapter 11: Pyrimidines
- 11.1 Synthesis of pyrimidinyl halides and triflates
- 11.2 Coupling reactions with organometallic reagents
- 11.3 Sonogashira reaction
- 11.4 Heck reaction
- 11.5 The carbonylation reaction
- 11.6 Heteroannulation
Chapter 12: Quinolines
- 12.1 Synthesis of quinoline electrophiles
- 12.2 Synthesis of quinoline nucleophiles
- 12.3 Cross-coupling reactions with organometallic reagents
- 12.4 Sonogashira reaction
- 12.5 Heck reaction
- 12.6 Miscellaneous reactions mediated by palladium
Chapter 13: Pyridazines
- 13.1 Synthesis of (pseudo)halopyridazines and (pseudo)halopyridazin-3(2H)-ones
- 13.2 Coupling reactions with organometallic reagents
- 13.3 Sonogashira reaction
- 13.4 Heck and intramolecular Heck reactions
- 13.5 Carbonylation reactions
- 13.6 C–N bond formation
Chapter 14: Industrial scale palladium chemistry
- 14.1 Introduction
- 14.2 Pharmaceutical products
- 14.3 Cosmaceuticals
- 14.4 Agrochemical products
- 14.5 Material sciences
- 14.6 Polymer chemistry
- 14.7 New catalyst developments in fine chemical synthesis
- 14.8 Amination
- 14.9 Carbonylation
- 14.10 Amidocarbonylation
Product details
- No. of pages: 658
- Language: English
- Copyright: © Elsevier Science 2006
- Published: October 30, 2006
- Imprint: Elsevier Science
- eBook ISBN: 9780080914411
About the Editors
Jie Jack Li
Affiliations and Expertise
Gordon Gribble
Affiliations and Expertise
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