
PAKs, RAC/CDC42 (p21)-activated Kinases
Towards the Cure of Cancer and Other PAK-dependent Diseases
Description
Key Features
- This publication will be the very first book ever published solely focused on PAK family kinases
- Each chapter deals with the latest progress in PAK research written by a leading PAK expert with his or her own ideas and insight
- Each chapter of this book has been written in such a way that clinical doctors who seek the effective cure of these formidable diseases, in addition to research scientists and biomedical students will value this book
- This book describes in detail a number of PAK blockers which would be potentially useful for the therapy of these PAK-dependent diseases, and some of them are indeed available on the market inexpensively, without any side effect
Readership
Table of Contents
List of Contributors
Introduction: Pushing the Boundary Toward Clinical Application: After 35 Years, PAK Research Comes of Age
Acknowledgments
References
1. Functional Maturation of PAKs from Unicellular to Multicellular Organisms
Abbreviations
1.1 Introduction
1.2 MIHCKs/PAKs and Myosin I in Unicellular Acanthamoeba and Multicellular Dictyostelium
1.3 PAK Evolution Among Metazoans (Unicellular Versus Multicellular)
1.4 PIX in Fruit Fly Drosophila and Nematode C. elegans
1.5 FYN/ETK-Dependent Activation of PAK1
1.6 Evolution of Merlin, Nischarin, and LBK1 (PAK Inhibitors)
1.7 Concluding Remarks
Acknowledgment
References
2. Oncogenicity of PAKs and Their Substrates
Abbreviations
2.1 Introduction
2.2 Loss of Contact Inhibition of Growth
2.3 Serum-Independent Growth
2.4 Anchorage-Independent Growth
2.5 Tumor-Induced Angiogenesis
2.6 Metastasis/Invasion
2.7 PAK1/PAK4-Dependent Solid Tumors
2.8 Oncogenic Targets of PAKs
2.9 Concluding Remarks
Acknowledgments
References
3. Natural or Synthetic Therapeutics That Block PAKs
Abbreviations
3.1 Introduction
3.2 Synthetic Chemical Therapeutics
3.3 Natural PAK1 Blockers
3.4 PAK1 Blockers = AMPK Activators
Acknowledgments
References
4. PAK1–3 in Infectious Diseases
4.1 Malaria Infection
4.2 Enterobacterial Infection
4.3 Viral Infection
Acknowledgments
References
5. PAK1 in Brain Diseases or Disorders
Abbreviations
5.1 Introduction
5.2 Tumorigenesis: NF, TSC, Retinoblastoma, and Gliomas
5.3 Epilepsy
5.4 Mental Retardation
5.5 Schizophrenia
5.6 Depression
References
6. PAK1 in Alzheimer’s and Huntington’s Diseases
Abbreviations
6.1 Alzheimer’s Disease
6.2 Huntington’s Disease
Acknowledgments
References
7. PAK1 Controls the Lifespan
Abbreviations
7.1 Introduction
7.2 Snell Dwarf Mice
7.3 RAC-Deficient Drosophila
7.4 PAK1 Blockers Extend the Lifespan of Tiny Animals
7.5 Crosstalk Between PI-3 kinase-PAK1 and TOR-S6K Signaling Pathways
7.6 The Nematode Caenorhabditis japonica as a Quicker Animal Model for Elixir Screening
7.7 Antiaging (Methuselah) Venture
Acknowledgments
References
8. 3D Structure and Physiological Regulation of PAKs
8.1 The PAK Family of Protein Kinases
8.2 Structural Mechanisms of PAK Regulation
8.3 Alternative Mechanisms Leading to PAK Activation
8.4 PAK Substrate Specificity and Downstream Signaling Events
Acknowledgments
References
Epilogue: “Lateral Thinking” Is the Key to a Great Leap in Biomedical Sciences
References
About the Authors
Product details
- No. of pages: 276
- Language: English
- Copyright: © Elsevier 2013
- Published: January 23, 2013
- Imprint: Elsevier
- eBook ISBN: 9780124072107
About the Editor
Hiroshi Maruta
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