Pain, Volume 81

1st Edition

Editors: Fernando Cervero Troels Jensen
Hardcover ISBN: 9780444519016
eBook ISBN: 9780080544984
Imprint: Elsevier
Published Date: 10th May 2006
Page Count: 944
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Table of Contents

Section 1 Pain and neurology

1. Pain and hyperalgesia: definitions and theories. R.-D. Treede (Mainz, Germany)

2. Pain as a disease. J.D. Loeser (Seattle, WA, USA)

Section 2 The neurobiology of pain Peripheral signaling of pain

3. Nociceptors: neurogenic inflammation. H. O. Handwerker (Nürnberg, Germany)

4. Primary hyperalgesia and nociceptor sensitization. L. Johanek, B. Shim and R.A. Meyer (Baltimore, MD, USA)

5. Molecular mechanisms of nociception and pain. J.N. Wood (London, UK)

Spinal cord processing

6. Anatomy and neurochemistry of the dorsal horn. A.J. Todd (Glasgow, UK)

7. Pain and the spinal cord. F. Cervero (Montreal, Canada)

8. Ascending nociceptive pathways. L. Villanueva, A. Lopez-Avila and L. Monconduit (Clermont-Ferrand, France)

9. Spinal mechanisms of hyperalgesia, K.N. Westlund (Galveston, TX, USA)

Supraspinal processing

10. Brain stem and thalamic relays. J.O. Dostrovsky (Toronto, Canada)

11. Subcortical processing of nociceptive information: basal ganglia and amygdala. V. Neugebauer (Galveston, TX, USA)

12. Cortical mechanisms mediating acute and chronic pain in humans. K. Casey and T.D. Tran (Ann Arbor, MI, USA and Ho Chi Minh City, Vietnam)

Endogenous pain modulation

13. Descending inhibitory systems. A.Pertovaara and A.Almeida (Helsinki,Finland and Braga,Portugal)

14. Descending excitatory systems. M.H. Ossipov and F. Porreca (Tucson,AZ,USA)

15. Descending pain modulation as a component of homeostasis. P. Mason (Chicago,IL,USA)

Section 3 The pathophysiology of pain

16. Pathological changes in the nociceptor: alterations in TRPV1 activity and Expression. M. Caterina (Baltimore, MD, USA)

17. Cytokinins and pain. C. Sommer (Würzburg, Germany)

18. Itch and cold allodynia. M. Sch


This volume provides a comprehensive accounting of pain and its relation to neurology. It is dedicated entirely to the mechanisms and clinical aspects of the subject, and provides a wealth of information on the latest neurobiological and clinical data surrounding the topic.

From discussions of the physiology and pathology of the pain pathways from signaling, via spinal cord and supraspinal processing to endogenous pain modulation, users will gain an invaluable reference that provides a new understanding of pain related topics, including cytokines, sex differences, and the autonomic nervous system.

Practicing clinicians, internists, surgeons, and those in the fields of psychiatry and gerontology will gain a greater understanding of this challenging topic with chapters that deal extensively with peripheral and central pain conditions, including specific disorders such as fibromyalgia, whiplash, psychiatric diseases, dementia, and even cancer. In addition, treatments for neuropathic pain are also thoroughly presented and discussed.

Key Features

  • A comprehensive guide to the topic of pain and its relation to neurology
    Invaluable information on specific topics of interest, including discussions of pain and its implications for related diseases and conditions such as fibromyalgia, whiplash, and even psychiatric disorders
    Treatment protocols for neuropathic pain and patient care


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© Elsevier 2006
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About the Editors

Fernando Cervero Editor

Affiliations and Expertise

Director, Anesthesia Research Unit (Faculty of Medicine), Faculty of Dentistry and McGill Center for Pain Reserach, McGill University, Montreal, Canada Professor and Director

Troels Jensen Editor

Affiliations and Expertise

Professor of Experimental and Clinical Pain Research, Danish Pain Research Center, Aarhus University Hospital, Aarhurs, Denmark