Oxygen Biology and Hypoxia

Oxygen Biology and Hypoxia

1st Edition - November 8, 2007

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  • Editors: Helmut Sies, Bernard Bruene
  • Hardcover ISBN: 9780123739704
  • eBook ISBN: 9780080554860

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For over fifty years the Methods in Enzymology series has been the critically acclaimed laboratory standard and one of the most respected publications in the field of biochemistry. The highly relevant material makes it an essential publication for researchers in all fields of life and related sciences. This volume features articles on the topic of oxygen biology and hypoxia.


Biochemists and researchers in related life science disciplines.

Table of Contents

  • Section I. Hypoxia-inducible factor

    Chapter 1
    HIF PAS domains: structure and function
    Thomas H. Scheuermann, Jinsong Yang, Lei Zhang, Kevin H. Gardner, and Richard K. Bruick

    Chapter 2
    Structure-function analysis of HIF
    Lorenz Poellinger

    Chaper 3
    HIF Prolyl Hydroxylase: Purification and Assays of PHD2
    Kirsty S. Hewitson, Christopher J. Schofield, Peter J. Ratcliffe

    Chapter 4
    Determination and modulation of prolyl-4-hydroxylase domain (PHD) oxygen sensor activity
    Renato Wirthner, Kuppusamy Balamurugan, Daniel P. Stiehl, Sandra Barth, Patrick Spielmann, Felix Oehme, Ingo Flamme, Dörthe M. Katschinski, Roland H. Wenger and Gieri Camenisch

    Chapter 5
    Characterisation of ankyrin-repeat containing proteins as substrates of the asparaginyl hydroxylase Factor Inhibiting HIF (FIH-1).
    Sarah Linke, Rachel J. Hampton-Smith, Daniel J. Peet

    Chapter 6
    Transgenic Models to Understand HIF Function
    Andrew Doedens and Randall S. Johnson

    Chapter 7
    The Silencing Approach of the Hypoxia Signalling Pathway"
    Edurne Berra and Jacques Pouyssegur

    Chapter 8
    Cellular and developmental adaptations to hypoxia; a Drosophila perspective
    Nuria Magdalena Romero, Andrés Dekanty, Pablo Wappner

    Section II. Erythropoietin

    Chapter 9
    Constitutively overexpressed erythropoietin reduces infarct size in a mouse model of permanent coronary artery ligation
    Giovanni G. Camici, Thomas Stallmach, Matthias Hermann, Rutger Hassink, Peter Doevendans, Beat Grenacher, Alain Hirschy, Johannes Vogel, Thomas F. Lüscher, Frank Ruschitzka and Max Gassmann

    Chapter 10
    Control of erythropoietin gene expression and its use in medicine
    Wolfgang Jelkmann

    Chapter 11
    Role of HIF-2 in endothelial development and hematopoiesis
    Osamu Ohneda1,3, Masumi Nagano1,3 and Yoshiaki Fujii-Kuriyama

    Section III. Hypoxia and adaptation

    Chapter 12
    Wanja M. Bernhardt, Christina Warnecke, Carsten Willam, Michael S. Wiesener and
    Kai-Uwe Eckardt

    Chapter 13
    Hypoxia and regulation of mRNA translation
    Marianne Koritzinsky and Bradly G. Wouters

    Chapter 14
    Hypoxia and the Unfolded Protein Response
    Constantinos Koumenis, Meixia Bi, Jiangbin Ye, Douglas Feldman and Albert C. Koong

    Section IV. Hypoxia and tumor biology

    Chapter 15
    Tumor hypoxia in cancer therapy
    J. Martin Brown

    Chapter 16
    HIF Gene Expression in Cancer Therapy
    By Denise A. Chan, Adam J. Krieg, Sandra Turcotte, and Amato J. Giaccia

    Chapter 17
    Analysis of HIF-1 Expression and Its Effects on Invasion and Metastasis
    Balaji Krishnamachary, Gregg L. Semenza

    Chapter 18
    Macrophage migration inhibitory factor (MIF) manipulation and evaluation in tumoral hypoxic adaptation
    Millicent Winner, Lin Leng, Wayne Zundel and Robert A. Mitchell

    Chapter 19
    The von Hippel-Lindau Tumor Suppressor Protein: An Update
    William G. Kaelin, Jr.

    Chapter 20
    Hypoxia Inducible Factor 1 (HIF-1) inhibitors
    Giovanni Melillo

    Section V. Hypoxia and inflammatory mediators

    Chapter 21
    Regulation of HIF during Inflammation
    Stilla Frede, Utta Berchner-Pfannschmidt, Joachim Fandrey

    Chapter 22
    Superoxide and derived reactive oxygen species in the regulation of hypoxia-inducible factors
    Agnes Görlach, Thomas Kietzmann

    Chapter 23
    Genetics of mitochondrial electron transport chain in regulating oxygen sensing
    Eric L. Bell and Navdeep S. Chandel

    Chapter 24
    Hypoxia inducible factor-1 (HIF-1) under the control of nitric oxide (NO)
    Bernhard Brüne and Jie Zhou

    Chapter 25
    Hypoxic regulation of NF-κB signalling
    Eoin P. Cummins, Katrina M. Comerford, Carsten Scholz, Ulrike Bruning & Cormac T. Taylor

Product details

  • No. of pages: 592
  • Language: English
  • Copyright: © Academic Press 2007
  • Published: November 8, 2007
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123739704
  • eBook ISBN: 9780080554860

About the Serial Volume Editors

Helmut Sies

Helmut Sies, MD, PhD (hon), studied medicine at the universities of Tübingen, Munich, and Paris. He was the professor and chair of the Institute for Biochemistry and Molecular Biology I at Heinrich-Heine-University Düsseldorf, Germany, where he is now professor emeritus. He is a member of the German National Academy of Sciences Leopoldina and was the president of the North Rhine-Westphalian Academy of Sciences and Arts. He was named ‘Redox Pioneer’; was the president of the Society for Free Radical Research International (SFRRI). Helmut Sies introduced the concept of “Oxidative Stress” in 1985, and was the first to reveal hydrogen peroxide as a normal constituent of aerobic cell metabolism. His research interests comprise redox biology, oxidants, antioxidants, micronutrients.

Affiliations and Expertise

Heinrich-Heine-University Düsseldorf, Germany

Bernard Bruene

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