Oxidative Stress

Oxidative Stress

Its Mechanisms, Impacts on Human Health and Disease Onset

1st Edition - October 23, 2022

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  • Author: Harold Zeliger
  • Paperback ISBN: 9780323918909
  • eBook ISBN: 9780323914581

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Oxidative Stress: Its Impact on Human Health and Disease Onset examines all factors known to elevate oxidative stress (OS) and the mechanism of OS disease causation.  Sections cover the causes and prevention of oxidative stress, the types of chemical exposures and environmental factors that precipitate disease, disease hallmarks and biomarkers, disease clusters, disease co-morbidities, free radical attacks at the cellular level, and the Oxidative Stress Index tool, its premise, and how it can be used to identify the primary causes of specific diseases and predict the likelihood of disease onset. With comprehensive coverage of not only the impact of OS due to chemical exposure but also the consequences of environmental factors, this book is a valuable resource for researchers and scientists in toxicology and environmental science, health practitioners, public health professionals, and others who wish to broaden their knowledge on this topic.

Key Features

  • Covers the chemical exposures and environmental factors that cause oxidative stress
  • Provides further understanding on the mechanisms of oxidative damage response and disease
  • Shows how oxidative stress and its role can be determined non-invasively via the Oxidative Stress Index


Researchers, toxicologists-particularly those engaged in mechanistic research, clinicians, academics, public health officials; industrial hygienists, chemical manufacturers and those responsible for workplace safety

Table of Contents

  • Dedication

    1. Introduction
    2. Chemicals and chemical mixtures
    3. Particles and fibers
    4. Air pollution
    5. Water and soil pollution
    6. Alcohol
    7. Tobacco
    8. Electromagnetic Radiation
    9. Inflammation
    10. Food
    11. Sleep deprivation
    12. Pharmaceuticals
    13. Psychological stress
    14. Genetics and epigenetics
    15. Aging
    16. Diseases and co-morbidities
    17. Total oxidative stress and disease
    18. Free radicals

    19. Aging mechanism
    20. Obesity
    21. Cancer
    22. Atherosclerosis
    23. Alzheimer’s disease
    24. Type 2 diabetes
    25. Rheumatoid arthritis
    26. Asthma
    27. Liver cirrhosis
    28. Chronic kidney disease
    29. Co-morbidities

    30. Oxidative stress index
    31. Condensed oxidative stress index
    32. Oxidative stress index and Alzheimer’s disease
    33. Oxidative stress index and public health surveys
    34. Oxidative stress index and predicting COVID-19 severity
    35. Lowering oxidative stress
    36. Global warming and disease

Product details

  • No. of pages: 500
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: October 23, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323918909
  • eBook ISBN: 9780323914581

About the Author

Harold Zeliger

Dr. Harold I. Zeliger holds a PhD in organic chemistry and has been a professor of chemistry and environmental science. He is a Certified Professional Chemist, a Board- Certified Forensic Examiner, and an EPA Certified Laboratory Director. Dr. Zeliger is the author of 51 technical publications, including basic research journal articles and patents. In his more than 40 years in the Chemical Process Industry, he has personally developed many industrial and consumer chemical products, designed chemical product warning labels and written Material Safety Data Sheets for toxic and flammable chemicals. Dr. Zeliger has investigated hundreds of toxic chemical exposures, environmental spills and discharges, chemical fires and explosions nationally and internationally. He has served repeatedly as an expert witness for both plaintiffs and defendants in chemical product, process, toxic exposure, environmental, flammable, intellectual property and subrogation claims. Dr. Zeliger has provided services for numerous forensic examinations, technology transfer and due diligence investigations. Dr. Zeliger’s research is in the area of chemical toxicology. His published work includes papers on the toxic effects of chemical mixtures and chemical causes of cancer clusters and two editions of Human Toxicology of Chemical Mixtures, Second Edition.

Affiliations and Expertise

Toxic and Flammable Chemical Consultant and Expert Witness; Certified Professional Chemist and Board Certified Forensic Examiner; Technology Transfer and Due Diligence Investigator, USA

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