Description

Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders.

Key Features

* Contains the latest information on the subject of neurodegenerative disorders * Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems

Readership

Researchers, clinicians and students in the fields of neuroscience, neurology, biochemistry and drug discovery who are interested in neurodegenerative disorders.

Table of Contents

1 Advances in our understanding of Neurodegeneration. Kurt A. Jellinger. 2 Mitochondrial mutagenesis in the brain in forensic and pathological research Nicole von Wurmb-Schwark 3 Genetic and environmental factors in neurodegenerative diseases Fabio Coppedè and Lucia Migliore 4 Nitric oxide and cellular stress response in brain aging and neurodegenerative disorders Vittorio Calabrese, Cesare Mancuso, Carlo De Marco, Anna Maria Giuffrida Stella and D. Allan Butterfield. 5 Oxidative Stress and Radiation-induced Late Normal Tissue Injury M.E.C. Robbinsand W. Zhao 6 Oxidative stress-induced death in the nervous system: cell cycle dependent for independent? Brett C. Langley 7 Redox imbalance in Parkinson’s disease. Daniela Berg. 8 Genes and Oxidative Stress in Sporadic and Familial Parkinsonism : cDNA Microarray Studies. Youdum M.B.H., Grunblatt E, Mandel S, Riederer P. 9 Down syndrome, antioxidant balance and the “gene dosage effect” hypothesis. Judy de Haan, P.J. Crack, M. Pritchard and I. Kola 10 The role of levodopa in the chronic neurodegenerative disorder Parkinson’s disease. Thomas Muller. 11 Reactive oxygen metabolites (ROMs) as an index of oxidative stress in obstructive sleep apnea patients. Prof. K. Christou, K.I. Gourgoulianis. 12 The Key Role of Oxidative Stress in Alzheimer Disease. George Perry, Mark A. Smith, Paula I. Moreira, Akihiko Nunomu

Details

No. of pages:
794
Language:
English
Copyright:
© 2007
Published:
Imprint:
Elsevier Science
Electronic ISBN:
9780080489490
Print ISBN:
9780444528094

About the editors