Oxidative Stress and Dietary Antioxidants in Neurological Diseases

Oxidative Stress and Dietary Antioxidants in Neurological Diseases provides an overview of oxidative stress in neurological diseases and associated conditions, including behavioral aspects and the potentially therapeutic usage of natural antioxidants in the diet. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this. The book examines basic processes of oxidative stress—from molecular biology to whole organs—relative to cellular defense systems, and across a range of neurological diseases.

Sections discuss antioxidants in foods, including plants and components of the diet, examining the underlying mechanisms associated with therapeutic potential and clinical applications. Although some of this material is exploratory or preclinical, it can provide the framework for further in-depth analysis or studies via well-designed clinical trials or the analysis of pathways, mechanisms, and components in order to devise new therapeutic strategies. Very often oxidative stress is a feature of neurological disease and associated conditions which either centers on or around molecular and cellular processes. Oxidative stress can also arise due to nutritional imbalance during a spectrum of timeframes before the onset of disease or during its development.

• Offers an overview of oxidative stress from molecular biology to whole organs
• Discusses the potentially therapeutic usage of natural antioxidants in the patient diet
• Provides the framework for further in-depth analysis or studies of potential treatments

Neurologists, neuroscientists, advanced graduate students, nutritionists, dieticians, health care professionals and food scientists

Foreword
Una Macleod

1. The role of reactive oxygen species in the pathogenic pathways of depression
Masakazu Ibi and Chihiro Yabe-Nishimura

2. The relationship between the blood-brain barrier, degenerative neuropathy, and oxidative stress
David Fisher and Olufemi A. Alamu

3. Neuroinflammatory processes and oxidative stress
Tameka A. Clemons, Na’Taki Osborne Jelks, L. Monique Vance, and Kimberly Williams

4. Revisiting the oxidative stress theory of aging: Molecular mechanisms underlying brain aging
Joana C. d’Avila

5. Neuroblastoma and oxidative stress: From pathogenesis to in vitro models of neurodegeneration
Anthea Di Rita and Flavie Strappazzon

6. Oxidative stress in epileptogenesis: Febrile seizures, chemoconvulsant pilocarpine, and electrical stimulation
David Agustin León Navarro, María Crespo, and Mairena Martín

7. DJ-1 in astrocytic neuroprotection to oxidative stress
Amanda J. Edson, Helena A. Hushagen, and Kari E. Fladmark

8. Oxidative stress markers in seizures and epilepsy: Methods and applications to models
Laura Medina-Ceja, Kenia Pardo-Peña, and Alberto Morales-Villagrán

9. Antioxidant therapy, oxidative stress, and blood-brain barrier: The road of dietary antioxidants
Miguel Pinto, Sofia Benfeito, Carlos Fernandes, and Fernanda Borges

10. Antioxidant and neuroprotective properties of Mediterranean oils: Argan oil, olive oil, and milk thistle seed oil
Asmaa Badreddine, Amira Zarrouk, Wiem Meddeb, Thomas Nury, Leila Rezig, Meryam Debbabi, Fatima Zohra Bessam, Fatiha Brahmi, Anne Vejux, Mondher Mejri, Boubker Nasser, and Gérard Lizard

11. Aromatic plants: A source of compounds with antioxidant and neuroprotective effects
Sandra Gonc¸alves, Inês Mansinhos, and Anabela Romano

12. The elderly, use of antioxidants and memory
William K. Summers

13. Aspidosperma pyrifolium Mart. antioxidants features and neuronal tissues
Dayane Pessoa de Araújo and Glauce Socorro de Barros Viana

14. Berberine neuroprotection and antioxidant activity
Mohsen Imenshahidi and Hossein Hosseinzadeh

15. Carnosic acid and carnosol: Neuroprotection and the mitochondria
Marcos Roberto de Oliveira

16. Coconut oil and antioxidative neuroprotection
Siong Meng Lim, Nur Syafiqah Rahim, and Kalavathy Ramasamy

17. Antioxidant effects of Curcuma longa and its active constituent, curcumin, for the therapy of neurological disorders
Bibi Marjan Razavi and Hossein Hosseinzadeh

18. Neuroprotective mechanisms of Ginkgo biloba against oxidative stress
Hoi Man Cheung and David Tai Wai Yew

19. Morinda citrifolia Linn. (Noni) fruit, antioxidant effects, and neuroprotection
Vijayapandi Pandy, Srinivasa Reddy Bonam, Anji Reddy Raya, and Rama Rao Nadendla

20. Naringin and naringenin in neuroprotection and oxidative stress
Pauline Maciel August and Bernardo Gindri dos Santos

21. Nigella sativa L. and thymoquinone as neuroprotective antioxidants
Alireza Tavakkoli and Hossein Hosseinzadeh

22. Dietary antioxidants, epigenetics, and brain aging: A focus on resveratrol
Christian Griñán-Ferré, Vanesa Izquierdo, and Mercè Pallàs

23. The role of saffron and its main components on oxidative stress in neurological diseases: A review
Marjan Nassiri-Asl and Hossein Hosseinzadeh

24. Sulforaphane and its modulation of brain redox status: The mitochondria as a target
Marcos Roberto de Oliveira

25. Recommended resources for oxidative stress and dietary antioxidants in neurological diseases
Rajkumar Rajendram, Vinood B. Patel, and Victor R. Preedy

Index