Oxidative Stress and Dietary Antioxidants in Neurological Diseases

Oxidative Stress and Dietary Antioxidants in Neurological Diseases

1st Edition - June 11, 2020

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  • Editors: Colin Martin, Victor Preedy
  • eBook ISBN: 9780128177815
  • Paperback ISBN: 9780128177808

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Oxidative Stress and Dietary Antioxidants in Neurological Diseases provides an overview of oxidative stress in neurological diseases and associated conditions, including behavioral aspects and the potentially therapeutic usage of natural antioxidants in the diet. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this. The book examines basic processes of oxidative stress—from molecular biology to whole organs—relative to cellular defense systems, and across a range of neurological diseases. Sections discuss antioxidants in foods, including plants and components of the diet, examining the underlying mechanisms associated with therapeutic potential and clinical applications. Although some of this material is exploratory or preclinical, it can provide the framework for further in-depth analysis or studies via well-designed clinical trials or the analysis of pathways, mechanisms, and components in order to devise new therapeutic strategies. Very often oxidative stress is a feature of neurological disease and associated conditions which either centers on or around molecular and cellular processes. Oxidative stress can also arise due to nutritional imbalance during a spectrum of timeframes before the onset of disease or during its development.  

Key Features

  • Offers an overview of oxidative stress from molecular biology to whole organs
  • Discusses the potentially therapeutic usage of natural antioxidants in the patient diet
  • Provides the framework for further in-depth analysis or studies of potential treatments


Neurologists, neuroscientists, advanced graduate students, nutritionists, dieticians, health care professionals and food scientists

Table of Contents

  • Foreword
    Una Macleod

    Part I: Oxidative stress and neurological diseases

    1. The role of reactive oxygen species in the pathogenic pathways of depression
    Masakazu Ibi and Chihiro Yabe-Nishimura

    2. The relationship between the blood-brain barrier, degenerative neuropathy, and oxidative stress
    David Fisher and Olufemi A. Alamu

    3. Neuroinflammatory processes and oxidative stress
    Tameka A. Clemons, Na’Taki Osborne Jelks, L. Monique Vance, and Kimberly Williams

    4. Revisiting the oxidative stress theory of aging: Molecular mechanisms underlying brain aging
    Joana C. d’Avila

    5. Neuroblastoma and oxidative stress: From pathogenesis to in vitro models of neurodegeneration
    Anthea Di Rita and Flavie Strappazzon

    6. Oxidative stress in epileptogenesis: Febrile seizures, chemoconvulsant pilocarpine, and electrical stimulation
    David Agustin León Navarro, María Crespo, and Mairena Martín

    7. DJ-1 in astrocytic neuroprotection to oxidative stress
    Amanda J. Edson, Helena A. Hushagen, and Kari E. Fladmark

    8. Oxidative stress markers in seizures and epilepsy: Methods and applications to models
    Laura Medina-Ceja, Kenia Pardo-Peña, and Alberto Morales-Villagrán

    Part II: Antioxidants and neurological diseases

    9. Antioxidant therapy, oxidative stress, and blood-brain barrier: The road of dietary antioxidants
    Miguel Pinto, Sofia Benfeito, Carlos Fernandes, and Fernanda Borges

    10. Antioxidant and neuroprotective properties of Mediterranean oils: Argan oil, olive oil, and milk thistle seed oil
    Asmaa Badreddine, Amira Zarrouk, Wiem Meddeb, Thomas Nury, Leila Rezig, Meryam Debbabi, Fatima Zohra Bessam, Fatiha Brahmi, Anne Vejux, Mondher Mejri, Boubker Nasser, and Gérard Lizard

    11. Aromatic plants: A source of compounds with antioxidant and neuroprotective effects
    Sandra Gonc¸alves, Inês Mansinhos, and Anabela Romano

    12. The elderly, use of antioxidants and memory
    William K. Summers

    13. Aspidosperma pyrifolium Mart. antioxidants features and neuronal tissues
    Dayane Pessoa de Araújo and Glauce Socorro de Barros Viana

    14. Berberine neuroprotection and antioxidant activity
    Mohsen Imenshahidi and Hossein Hosseinzadeh

    15. Carnosic acid and carnosol: Neuroprotection and the mitochondria
    Marcos Roberto de Oliveira

    16. Coconut oil and antioxidative neuroprotection
    Siong Meng Lim, Nur Syafiqah Rahim, and Kalavathy Ramasamy

    17. Antioxidant effects of Curcuma longa and its active constituent, curcumin, for the therapy of neurological disorders
    Bibi Marjan Razavi and Hossein Hosseinzadeh

    18. Neuroprotective mechanisms of Ginkgo biloba against oxidative stress
    Hoi Man Cheung and David Tai Wai Yew

    19. Morinda citrifolia Linn. (Noni) fruit, antioxidant effects, and neuroprotection
    Vijayapandi Pandy, Srinivasa Reddy Bonam, Anji Reddy Raya, and Rama Rao Nadendla

    20. Naringin and naringenin in neuroprotection and oxidative stress
    Pauline Maciel August and Bernardo Gindri dos Santos

    21. Nigella sativa L. and thymoquinone as neuroprotective antioxidants
    Alireza Tavakkoli and Hossein Hosseinzadeh

    22. Dietary antioxidants, epigenetics, and brain aging: A focus on resveratrol
    Christian Griñán-Ferré, Vanesa Izquierdo, and Mercè Pallàs

    23. The role of saffron and its main components on oxidative stress in neurological diseases: A review
    Marjan Nassiri-Asl and Hossein Hosseinzadeh

    24. Sulforaphane and its modulation of brain redox status: The mitochondria as a target
    Marcos Roberto de Oliveira

    25. Recommended resources for oxidative stress and dietary antioxidants in neurological diseases
    Rajkumar Rajendram, Vinood B. Patel, and Victor R. Preedy


Product details

  • No. of pages: 444
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: June 11, 2020
  • Imprint: Academic Press
  • eBook ISBN: 9780128177815
  • Paperback ISBN: 9780128177808

About the Editors

Colin Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Mental Health, Bickinghamshire New University, High Wycombe, Buckinghamshire, UK

Victor Preedy

Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

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