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Oxidative Stress and Dietary Antioxidants in Neurological Diseases - 1st Edition - ISBN: 9780128177808, 9780128177815

Oxidative Stress and Dietary Antioxidants in Neurological Diseases

1st Edition

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Editors: Colin R. Martin Victor Preedy
Paperback ISBN: 9780128177808
eBook ISBN: 9780128177815
Imprint: Academic Press
Published Date: 11th June 2020
Page Count: 444
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Oxidative Stress and Dietary Antioxidants in Neurological Diseases provides an overview of oxidative stress in neurological diseases and associated conditions, including behavioral aspects and the potentially therapeutic usage of natural antioxidants in the diet. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this. The book examines basic processes of oxidative stress—from molecular biology to whole organs—relative to cellular defense systems, and across a range of neurological diseases.

Sections discuss antioxidants in foods, including plants and components of the diet, examining the underlying mechanisms associated with therapeutic potential and clinical applications. Although some of this material is exploratory or preclinical, it can provide the framework for further in-depth analysis or studies via well-designed clinical trials or the analysis of pathways, mechanisms, and components in order to devise new therapeutic strategies. Very often oxidative stress is a feature of neurological disease and associated conditions which either centers on or around molecular and cellular processes. Oxidative stress can also arise due to nutritional imbalance during a spectrum of timeframes before the onset of disease or during its development.  

Key Features

  • Offers an overview of oxidative stress from molecular biology to whole organs
  • Discusses the potentially therapeutic usage of natural antioxidants in the patient diet
  • Provides the framework for further in-depth analysis or studies of potential treatments


Neurologists, neuroscientists, advanced graduate students, nutritionists, dieticians, health care professionals and food scientists

Table of Contents

Una Macleod

Part I: Oxidative stress and neurological diseases

1. The role of reactive oxygen species in the pathogenic pathways of depression
Masakazu Ibi and Chihiro Yabe-Nishimura

2. The relationship between the blood-brain barrier, degenerative neuropathy, and oxidative stress
David Fisher and Olufemi A. Alamu

3. Neuroinflammatory processes and oxidative stress
Tameka A. Clemons, Na’Taki Osborne Jelks, L. Monique Vance, and Kimberly Williams

4. Revisiting the oxidative stress theory of aging: Molecular mechanisms underlying brain aging
Joana C. d’Avila

5. Neuroblastoma and oxidative stress: From pathogenesis to in vitro models of neurodegeneration
Anthea Di Rita and Flavie Strappazzon

6. Oxidative stress in epileptogenesis: Febrile seizures, chemoconvulsant pilocarpine, and electrical stimulation
David Agustin León Navarro, María Crespo, and Mairena Martín

7. DJ-1 in astrocytic neuroprotection to oxidative stress
Amanda J. Edson, Helena A. Hushagen, and Kari E. Fladmark

8. Oxidative stress markers in seizures and epilepsy: Methods and applications to models
Laura Medina-Ceja, Kenia Pardo-Peña, and Alberto Morales-Villagrán

Part II: Antioxidants and neurological diseases

9. Antioxidant therapy, oxidative stress, and blood-brain barrier: The road of dietary antioxidants
Miguel Pinto, Sofia Benfeito, Carlos Fernandes, and Fernanda Borges

10. Antioxidant and neuroprotective properties of Mediterranean oils: Argan oil, olive oil, and milk thistle seed oil
Asmaa Badreddine, Amira Zarrouk, Wiem Meddeb, Thomas Nury, Leila Rezig, Meryam Debbabi, Fatima Zohra Bessam, Fatiha Brahmi, Anne Vejux, Mondher Mejri, Boubker Nasser, and Gérard Lizard

11. Aromatic plants: A source of compounds with antioxidant and neuroprotective effects
Sandra Gonc¸alves, Inês Mansinhos, and Anabela Romano

12. The elderly, use of antioxidants and memory
William K. Summers

13. Aspidosperma pyrifolium Mart. antioxidants features and neuronal tissues
Dayane Pessoa de Araújo and Glauce Socorro de Barros Viana

14. Berberine neuroprotection and antioxidant activity
Mohsen Imenshahidi and Hossein Hosseinzadeh

15. Carnosic acid and carnosol: Neuroprotection and the mitochondria
Marcos Roberto de Oliveira

16. Coconut oil and antioxidative neuroprotection
Siong Meng Lim, Nur Syafiqah Rahim, and Kalavathy Ramasamy

17. Antioxidant effects of Curcuma longa and its active constituent, curcumin, for the therapy of neurological disorders
Bibi Marjan Razavi and Hossein Hosseinzadeh

18. Neuroprotective mechanisms of Ginkgo biloba against oxidative stress
Hoi Man Cheung and David Tai Wai Yew

19. Morinda citrifolia Linn. (Noni) fruit, antioxidant effects, and neuroprotection
Vijayapandi Pandy, Srinivasa Reddy Bonam, Anji Reddy Raya, and Rama Rao Nadendla

20. Naringin and naringenin in neuroprotection and oxidative stress
Pauline Maciel August and Bernardo Gindri dos Santos

21. Nigella sativa L. and thymoquinone as neuroprotective antioxidants
Alireza Tavakkoli and Hossein Hosseinzadeh

22. Dietary antioxidants, epigenetics, and brain aging: A focus on resveratrol
Christian Griñán-Ferré, Vanesa Izquierdo, and Mercè Pallàs

23. The role of saffron and its main components on oxidative stress in neurological diseases: A review
Marjan Nassiri-Asl and Hossein Hosseinzadeh

24. Sulforaphane and its modulation of brain redox status: The mitochondria as a target
Marcos Roberto de Oliveira

25. Recommended resources for oxidative stress and dietary antioxidants in neurological diseases
Rajkumar Rajendram, Vinood B. Patel, and Victor R. Preedy



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© Academic Press 2020
11th June 2020
Academic Press
Paperback ISBN:
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About the Editors

Colin R. Martin

Dr. Martin is a Professor of Mental Health at Buckinghamshire New University. He is a Registered Nurse, Chartered Health Psychologist, and a Chartered Scientist. He has published or has in press well over 250 research papers and book chapters. He is a keen book author and editor having written and/or edited several books all of which reflect his diverse academic and clinical interests that examine in-depth, the interface between mental health and physical health. These outputs include the Handbook of Behavior; Food and Nutrition (2011), Perinatal Mental Health: A Clinical Guide (2012); Nanomedicine and the Nervous System (2012), and the major reference works Comprehensive Guide to Autism (2014), Diet and Nutrition in Dementia and Cognitive Decline (2015), Comprehensive Guide to Post-Traumatic Stress Disorder (2016) and Metabolism and Pathophysiology of Bariatric Surgery: Nutrition, Procedures, Outcomes, and Adverse Effects (2017).

Affiliations and Expertise

Professor of Perinatal Mental Health, Institute of Clinical and Applied Health Research (ICAHR), University of Hull, UK

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is a staff member of the Faculty of Life Sciences and Medicine within King's College London. He is also a member of the Division of Diabetes and Nutritional Sciences (research) and the Department of Nutrition and Dietetics (teaching). Professor Preedy is also Director of the Genomics Centre of King's College London. Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1992, he received his Membership of the Royal College of Pathologists and in 1993 he gained his second doctorate (DSc), for his outstanding contribution to protein metabolism in health and disease. Professor Preedy was elected as a Fellow to the Institute of Biology in 1995 and to the Royal College of Pathologists in 2000. Since then he has been elected as a Fellow to the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health (2004). In 2009, Professor Preedy became a Fellow of the Royal Society for Public Health and in 2012 a Fellow of the Royal Society of Chemistry. Professor Preedy has carried out research when attached to Imperial College London, The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, USA and Germany. Prof Preedy is a leading expert on the science of health and has a long standing interest in neurological disease and tissue pathology. He has lectured nationally and internationally. To his credit, Professor Preedy has published over 600 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

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