Oxidative Stress and Biomaterials

Oxidative Stress and Biomaterials

1st Edition - May 31, 2016

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  • Authors: Thomas Dziubla, D Allan Butterfield
  • eBook ISBN: 9780128032701
  • Hardcover ISBN: 9780128032695

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Oxidative Stress and Biomaterials provides readers with the latest information on biomaterials and the oxidative stress that can pose an especially troubling challenge to their biocompatibility, especially given the fact that, at the cellular level, the tissue environment is a harsh landscape of precipitating proteins, infiltrating leukocytes, released oxidants, and fluctuations of pH which, even with the slightest shift in stasis, can induce a perpetual state of chronic inflammation. No material is 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic in all biological settings and situations. In this embattled terrain, the most we can hope for from the biomaterials we design is a type of “meso-compatibility,” a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction.

Key Features

  • Explores the challenges of designing and using biomaterials in order to minimize oxidative stress, reducing patterns of chronic inflammation and cell death
  • Brings together the two fields of biomaterials and the biology of oxidative stress
  • Provides approaches for the design of biomaterials with improved biocompatibility


Biomaterials community, Biomedical Engineers, Chemical Engineers

Table of Contents

    • List of Contributors
    • Preface
    • Chapter One. A Free Radical Primer
      • Abstract
      • 1.1 Free Radical Biology—Importance
      • 1.2 RED/OX Chemistry
      • 1.3 Biological Oxidation Events
      • 1.4 Conclusion and Final Thoughts
      • References
    • Chapter Two. Oxidative Stress, Inflammation, and Disease
      • Abstract
      • 2.1 Introduction
      • 2.2 ROS and Oxidative Stress: A Major Activator of Inflammatory Pathways
      • 2.3 Inflammation: A Major Cause of Oxidative Stress
      • 2.4 Oxidant Stress and Inflammation in Cellular Transformation, Apoptosis, and Necrosis
      • 2.5 Exploring the Link Between Oxidative Stress and Inflammation and the Onset of Various Diseases
      • 2.6 Antioxidants and Anti-Inflammatory Agents: Perspectives in Therapeutics
      • 2.7 Conclusions and Perspectives
      • Abbreviations
      • References
    • Chapter Three. Oxidative Stress, Inflammation, and the Corrosion of Metallic Biomaterials: Corrosion Causes Biology and Biology Causes Corrosion
      • Abstract
      • 3.1 Introduction
      • 3.2 Oxidation, Reduction, and Tribocorrosion at Metallic Biomaterial Surfaces
      • 3.3 Immune Cells, Inflammation, and ROS
      • 3.4 Metal Ions and Wear Debris Effects on Local Tissues
      • 3.5 Reduction Reactions and Cellular Viability
      • 3.6 ICIC of CoCrMo and Ti Alloys: ROS Effects on Corrosion and Wear
      • 3.7 Summary and Conclusions
      • Acknowledgments
      • References
    • Chapter Four. Oxidative Stress and Biomaterials: The Inflammatory Link
      • Abstract
      • 4.1 Introduction
      • 4.2 FBR to Biomaterials
      • 4.3 Effect of Physicochemical Properties of Biomaterial on Inflammation
      • 4.4 Relationship between Inflammation and Oxidative Stress
      • 4.5 Oxidative Stress as By-Product of Inflammatory Response to Biomaterial
      • 4.6 Impact of Oxidative Stress on Implanted Cells and Induction of Inflammation
      • 4.7 Conclusion
      • ReferenceS
    • Chapter Five. Nanoparticle Toxicity and Environmental Impact
      • Abstract
      • 5.1 Introduction
      • 5.2 Nanotoxicology
      • 5.3 Free Radicals, Reactive Oxygen Species, and Oxidative Stress
      • 5.4 Nanoparticle-Induced ROS Generation and Oxidative Stress
      • 5.5 Inflammation and Nanoparticles
      • 5.6 Systemic Toxicity
      • 5.7 Mechanisms of Nanoparticle Toxicity
      • 5.8 Genotoxic Effects of Nanoparticles
      • 5.9 Ecotoxicity of Nanoparticles and Its Environmental Impact
      • 5.10 Conclusion
      • Acknowledgments
      • References
    • Chapter Six. In Vitro Cellular Assays for Oxidative Stress and Biomaterial Response
      • Abstract
      • 6.1 Introduction to the In Vitro Cellular Assays
      • 6.2 Choice of Cell Lines and Animal Models
      • 6.3 “Real-Time” Cellular Assays for Detection of Oxidative Stress
      • 6.4 Fluorescent Probes and Dyes Based Detections
      • 6.5 Seahorse FX Technology Based Assays
      • 6.6 EPR Methods
      • 6.7 “Static” Assays for Detection of Oxidative Stress
      • 6.8 Conclusion
      • Abbreviations
      • References
    • Chapter Seven. Redox Interactions Between Nanomaterials and Biological Systems
      • Abstract
      • 7.1 Introduction
      • 7.2 Oxidative Stress by Inorganic Nanomaterials
      • 7.3 Oxidative Stress by Organic Nanomaterials
      • 7.4 Oxidative Stress and Nanomaterial Surface Chemistry
      • 7.5 Techniques for Evaluating Oxidative Stress Due to Nanomaterial Exposure
      • Acknowledgments
      • References
    • Chapter Eight. Hydrocyanines: A Versatile Family of Probes for Imaging Radical Oxidants In Vitro and In Vivo
      • Abstract
      • 8.1 Introduction
      • 8.2 The Hydrocyanines: A New Family of Fluorescent ROS Probes
      • References
    • Chapter Nine. Oxidation State as a Bioresponsive Trigger
      • Abstract
      • 9.1 Introduction
      • 9.2 Oxidation-Responsive Polymer Systems: Phase Transition Versus Polymer Degradation
      • 9.3 Utilizing Oxidation-Responsive Polymers in Drug Delivery
      • 9.4 Utilizing Oxidation-Responsive Polymers in Biodegradable Tissue Engineering Scaffolds
      • 9.5 Conclusion
      • References
    • Chapter Ten. Antioxidant Polymers as Biomaterial
      • Abstract
      • 10.1 Introduction
      • 10.2 Passive Delivery of Antioxidant Molecules by Polymers
      • 10.3 Intrinsically Antioxidant Polymers: Nonenzymatic Antioxidants
      • 10.4 Intrinsically Antioxidant Polymers: Enzymatic Antioxidants
      • 10.5 Intrinsically Antioxidant Polymers: Metal-Chelating Polymers
      • 10.6 In Vivo Oxidative Stress Modulation with Antioxidant Polymers
      • 10.7 Conclusions and Perspectives
      • References
    • Chapter Eleven. Oxidation of Total Joint Implants and Antioxidant Strategies: Designing Implants for Oxidative Stress Resistance
      • Abstract
      • 11.1 A Brief History of Total Joint Implants
      • 11.2 Oxidation Mechanisms of Total Joint Implants
      • 11.3 In Vitro Simulation of Oxidation and Characterization
      • 11.4 The Introduction of Antioxidants into Medical Grade UHMWPE
      • 11.5 Conclusion
      • References
    • Chapter Twelve. Targeted Antioxidant Interventions for Vascular Pathologies
      • Abstract
      • 12.1 Introduction
      • 12.2 Vascular Oxidative Stress and Inflammation in Dangerous Acute Conditions
      • 12.3 Markers of Oxidative Stress and Inflammation
      • 12.4 Antioxidant Interventions and Untargeted Delivery Systems
      • 12.5 Targeted Delivery of AOEs
      • 12.6 Conclusion: Challenges and Perspectives
      • References
    • Chapter Thirteen. Oral Mucositis as a Target for Antioxidant Biomaterial Therapy
      • Abstract
      • 13.1 Introduction
      • 13.2 Pathophysiology of OM
      • 13.3 Management and Treatment of OM
      • 13.4 Oxidative Stress Management and Antioxidant Therapy for OM
      • 13.5 A Case for Curcumin as an OM Therapeutic
      • 13.6 Challenges with Curcumin Delivery
      • 13.7 Advances in Curcumin Delivery Technologies
      • 13.8 Curcumin Delivery from Poly(Beta-Amino Ester) Polymers
      • 13.9 Conclusion
      • References
    • Index

Product details

  • No. of pages: 404
  • Language: English
  • Copyright: © Academic Press 2016
  • Published: May 31, 2016
  • Imprint: Academic Press
  • eBook ISBN: 9780128032701
  • Hardcover ISBN: 9780128032695

About the Authors

Thomas Dziubla

Dr. Thomas Dziubla, Ph.D. is the Associate Gill Professor and Director of Graduate Studies in the Department of Chemical and Materials Engineering at the University of Kentucky. He received his B.S. and Ph.D in Chemical Engineering from Purdue University (1998) and Drexel University (2002), respectively. In 2002–2004, he was an NRSA postdoctoral fellow in the Institute for Environmental Medicine at the University of Pennsylvania’s School of Medicine under the guidance of Dr. Vladimir Muzykantov, where he worked on the design of degradable polymeric nanocarriers for the delivery of antioxidants. His research group is interested in the design of new functional polymeric biomaterials, which can actively control local cellular oxidative stress for improved biomaterial integration and disease treatment. Dr. Dziubla is a member of Society for Biomaterials and American Institute of Chemical Engineers. He holds 8 patents, has authored over 50 peer reviewed publications and has started several companies that are currently commercializing technologies that have originated from his laboratory.

Affiliations and Expertise

Chemical and Materials Engineering, College of Engineering, University of Kentucky, Lexington, KY, USA

D Allan Butterfield

Professor, Department of Chemistry and Faculty Associate, Sanders-Brown Center on Aging, University of Kentucky. Also holds the position of Director, Center of Membrane Sciences and Free Radical Biology in Cancer Shared Resources. Professor since 1975 and has co-authored more than 500 articles in Bio-chemistry.

Affiliations and Expertise

Department of Chemistry, University of Kentucky, Lexington, KY, USA

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