Oxidants, Antioxidants, and Impact of the Oxidative Status in Male Reproduction - 1st Edition - ISBN: 9780128125014

Oxidants, Antioxidants, and Impact of the Oxidative Status in Male Reproduction

1st Edition

Editors: Ralf Henkel Luna Samanta Ashok Agarwal
Paperback ISBN: 9780128125014
Imprint: Academic Press
Published Date: 1st November 2018
Page Count: 325
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Oxidants, Antioxidants and Impact of the Oxidative Status in Male Reproduction is an essential reference for fertility practitioners as well as research and laboratory professionals interested in learning about the role of reactive oxygen species in sperm physiology and pathology. The editors have focused their research on unravelling the pathophysiology of oxidative stress mediated male infertility and recruited top researchers and clinicians to contribute chapters. This collection of expertise delves into the physico-chemical aspects of oxidative stress, including reductive stress which is engaging new research. Furthermore, the inclusion of clinical techniques to determine oxidative stress as well as the OMICS of reductive oxidative stress are new to the market. This is a must-have reference in the area of oxidative stress and male reproductive function.

Key Features

  • Offers comprehensive information on oxidative stress and its role in male reproduction, including new therapeutic approaches
  • Deals with current approaches to oxidative stress using OMICS platform
  • Designed for fertility practitioners, as well as reproductive researchers and laboratory professionals interested in learning about the role of reactive oxygen species in sperm physiology and pathology


Reproductive biologists, reproductive endocrinologists, academic clinicians interested in male reproduction, andrologists, and embryologists

Table of Contents

1. Basic Aspects
1.1. Life under Aerobic Conditions
1.2. The Oxidant Paradox
1.3. Reactive oxygen species
1.4. Oxidative stress in Male Reproductive Health
1.5. Leukocytes as a cause of oxidative stress
1.6. Spermatozoa as a cause of oxidative stress
1.7. Reductive stress
1.8. Causes of reductive stress in male reproduction
1.9. Physiological role of ROS in male reproduction
2. Clinical Aspects
2.1. Epidemiology of oxidative stress in male fertility
2.2. Sperm oxidative stress and its impact on fertilization
2.3. Pathophysiological role of ROS in male reproduction
2.3.1. Male genital tract infections and leukocytospermia
2.3.2. Varicocele
2.3.3. Malnutrition and obesity
2.3.4. Diabetes
2.3.5. Thyroid dysfunction
2.3.6. Ageing
2.4. Clinical techniques to determine oxidative stress
2.4.1. ROS
2.4.2. NBT
2.4.3. Antioxidative capacity
2.4.4. ORP
2.5. Treatment of oxidative stress - in vitro and in vivo
3. Current approaches
3.1. The OMICS in ROS-mediated sperm function
3.1.1. Genomics and epigenetics (genetic basis of OS and ROS)
3.1.2. Transcriptomics and regulatory RNA
3.1.3. Proteomics and posttranslational modification
3.1.4. Metabolomics
4. Future developments
5. Conclusions


No. of pages:
© Academic Press 2019
Academic Press
Paperback ISBN:

About the Editor

Ralf Henkel

Professor Henkel has expertise in male reproductive health - specialty: Andrology. He is a visiting reproductive scientist at the Cleveland Clinic. He studied Biology and Chemistry at the University of Marburg, Germany, and obtained his PhD investigating the protein secretion of rabbit blastocysts during early pregnancy. Dr. Henkel is currently Senior Professor for Reproductive Biology at the Department of Medical Bioscience at the University of the Western Cape, Bellville, South Africa. He has published more than 90 papers, contributed to nearly 30 books, and is a member of the Editorial Boards of five international journals and Co-Editor-in-Chief of Andrologia. His specialty is male reproductive health, including male infertility, sperm functions, impact of oxidative stress on sperm functions, DNA fragmentation and fertilization. Dr. Henkel investigates the effects of Traditional Medicine on male reproductive functions and the prostate in cases of prostate cancer and benign prostatic hyperplasia.

Affiliations and Expertise

Head of Department, Department of Medical Biosciences, University of the Western Cape, South Africa

Luna Samanta

Ashok Agarwal

Dr. Agarwal received his PhD in 1983 from Banaras Hindu University, India. He did his post-doctorate training in Reproductive Biology under a fellowship from The Rockefeller Foundation at Harvard Medical School. He was an Instructor in Surgery and then an Assistant professor of urology at Harvard Medical School from 1988 to 1992. He was appointed in 1993 by the Cleveland Clinic Foundation as the Head of the Clinical Andrology Center, which over the years under his leadership, has become a center of excellence in the United States for the diagnosis of male infertility and fertility preservation of men with oncological conditions. He is the recipient of over 100 research grants. His current research interests include studies on molecular markers of oxidative stress, DNA integrity, and proteomics in the pathophysiology of male and female reproduction, effect of radio frequency radiation on fertility and fertility preservation in patients with cancer. Dr. Agarwal is actively involved in laboratory and clinical studies looking at the efficacy of certain antioxidants in improving the fertility of male patients. He has published over 500 scientific papers and review articles in peer reviewed scientific journals, authored over 100 book chapters, and presented over 800 papers at both national and international scientific meetings. He has edited 18 medical text books/ manuals related to male infertility, ART, fertility preservation, DNA damage and antioxidants. He is the guest editor of 4 special journal issues. He is a member or office bearer of several professional societies including: American Society for Reproductive Medicine, American Society of Andrology, American Urological Association, Society for the Study of Male Reproduction and Society for the Study of Male Reproduction and Urology. Dr. Agarwal is active in basic and clinical research and his laboratory has trained more than 500 basic scientists and clinical researchers from the United States and more than 50 countries.

Affiliations and Expertise

Director, Center for Reproductive Medicine Professor, Lerner College of Medicine Cleveland Clinic, Cleveland, Ohio, USA

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