Table of Contents

Preface to the Fourth Edition


Editor’s Note

Part I: Introduction

Chapter 1. The Bone Organ System: Form and Function


Composition and Organization of Bone

Cellular Components of Bone

Bone Homeostasis

Basic Bone Mechanics



Chapter 2. The Nature of Osteoporosis

Defining Osteoporosis

Material and Structural Basis of Skeletal Fragility



Chapter 3. Reflections on Osteoporosis




Fragility Fractures

Bone Density and Fracture Risk






Chapter 4. Reflections on Development of Concepts of Intercellular Communication in Bone


Calcium Homeostasis – Developments of the 1960s

Discovery of Calcitonin

Inhibition of Bone Resorption by Calcitonin

Lessons from an Osteogenic Sarcoma

Emergence of Bone Cell Biology

Could Osteoblasts Regulate Osteoclasts?

The Origin of Osteoclasts – Mid-1970s

Osteoblast Regulation of Osteoclasts

Control of Osteoclast Formation

Hormone and Cytokine Control of Osteoclast Formation

The Physiologic Signaling Mechanisms in Osteoclast Control

Bone Remodeling

Coupling of Bone Formation to Resorption

Coupling Factor – from Matrix or Cells?

Communication from Osteocytes

Is There a Single “Coupling Factor”, Analogous to RANKL?

PTHrP as a Local Control Process

How Might PTHrP Participate?




Chapter 5. Osteo-Odyssey: A Memoir

Starting Out: From A to B One

Being the First Postdoc in Larry’s Lab

In the Academic World:


No. of pages:
© 2013
Academic Press
Electronic ISBN:
Print ISBN:

About the editors

David Dempster

David W. Dempster, PhD, is Professor of Clinical Pathology and Cell Biology at Columbia University in New York. He obtained his PhD from the University of Glasgow in Scotland and completed postdoctoral studies in Switzerland and France. Dr. Dempster is a Past President of the International Society of Bone Morphometry and a member of the Scientific Advisory Council of the National Osteoporosis Foundation. He is also a Fellow of the Royal Microscopical Society. Dr. Dempster’s iconic micrographs of osteoporotic bone have been widely reproduced in the scientific and popular press, including being displayed at the Smithsonian Institution in Washington, DC. Dr. Dempster is an Associate Editor of Osteoporosis International, and serves on the editorial boards of the Journal of Bone and Mineral Research, Bone and the Journal of Clinical Densitometry. His research studies have been continuously supported by the National Institutes of Health for the past 25 years. Dr. Dempster has published over 200 research papers on the pathophysiology and treatment of bone disese.

Marjorie Luckey

Marjorie M. Luckey, MD is Medical Director of the Osteoporosis and Metabolic Bone Disease Center at the Saint Barnabas Medical Center in Livingston, NJ. She holds board certifications in Internal Medicine and Endocrinology and Metabolism and has been actively engaged in bone disease research, education, and patient care since 1982. As Associate Professor of Reproductive Science at Mount Sinai Medical Center in New York, New York, her independent research and publications included NIH-supported studies of bone health and calcium metabolism in African-American women; studies on the effects of organ transplantation, genetic diseases, and primary biliary cirrhosis on bone health; and investigations into laboratory testing in osteoporotic women. In addition, she has participated in many multinational trials of new therapeutic agents for osteoporosis. Dr. Luckey is Chair of the Better Bones Project, a national education program designed to teach primary care physicians how to evaluate and treat osteoporosis. She is on the editorial board of the Journal of Clinical Densitometry, on the Scientific Advisory Council of the National Osteoporosis Foundation and is a member of the Bone Densitometry Certification Faculty for the International Society for Clinical Densitometry. She has also served on the Board of Directors of the International Society for Clinical Densitometry, the Practice Committee for The American Society of Bone and Mineral Research, and the National Bone Health Campaign Scientific Task Force for the Centers for Disease Control and Prevention.