3rd Edition - October 17, 2007

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  • Editors: Robert Marcus, David Feldman, Dorothy Nelson, Clifford Rosen
  • eBook ISBN: 9780080553474

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Now in its third edition, Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 percent continuing to make osteoporosis a hot topic in medicine. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in a field where direct care costs for osteoporitic fractures in the U.S. reach up to $18 billion each year.

Key Features

*Recognizes the critical importance of the Wnt signaling pathway for bone health
*Incorporates new chapters on osteocytes, phosphatonins, mouse genetics, and CNS and bone
*Examines essential updates on estrogen prevention and treatment and the recent results from the WHI
*Discusses the controversial topics of screening and clinical trial design for drug registration
*Includes essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, and parathyroid hormone
* Offers critical reviews of reproductive and hormonal risk factors, ethnicity, nutrition, therapeutics, management, and economics comprising a tremendous wealth of knowledge in a single source not found elsewhere


Academic and medical libraries as well as professionals in bone biology, endocrinology, osteology, neuroendocrinology; drug companies developing osteoporosis medications

Table of Contents

  • Introduction
    The Bone Organ System: Form and Function
    The Nature of Osteoporosis
    The Economics of Osteoporosis
    Reflections on Osteoporosis
    Skeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the
    Understanding of Osteoporosis
    Basic Science/Bone Biology
    Osteoblast Biology
    Osteoclast Biology
    The Regulatory Role of Matrix Proteins in Mineralization of Bone
    Development of the Skeleton
    Mouse Genetics as a Tool to Study Bone Development and Physiology
    Parathyroid Hormone and Parathyroid Hormone-Related Protein
    Vitamin D: Biology, Action, and Clinical Implications
    Regulation of Bone Cell Function by Estrogens
    Androgens and Skeletal Biology: Basic Mechanisms
    Wnt Signaling in Bone
    Cytokines and Bone Remodeling
    Skeletal Growth Factors
    Intercellular Communication During Bone Remodeling
    Structural and Biomechanics
    Skeletal Development: Mechanical Consequences of Growth, Aging and Disease
    Inhibition of Osteoporosis by Biophysical Intervention
    Biomechanics of Age-Related Fractures
    Bone Quality
    Epidemiology & Risk Factors
    Epidemiologic Methods in Studies of Osteoporosis
    Race, Ethnicity and Osteoporosis
    The Study of Osteoporotic Fractures (SOF): Major Findings and Contributions
    Bone Mineral Acquisition in Utero and During Infancy and Childhood
    Bone Acquisition in Adolescence
    Genetic Determinants of Osteoporosis
    Nutrition and Risk for Osteoporosis
    Physical Activity in Prevention of Osteoporosis and Associated Fractures
    Premenopausal Reproductive and Hormonal Characteristics and the Risk for Osteoporosis
    Non-Skeletal Risk Factors for Osteoporosis and Fractures
    Falls as Risk Factors for Fracture
    Assessment of Fracture Risk
    Outcomes of Osteoporotic Fractures
    Local and Systemic Factors in the Pathogenesis of Osteoporosis
    Animal Models for Osteoporosis
    Estrogen, Bone Homeostasis and Osteoporosis
    Postmenopausal Osteoporosis: How the Hormonal Changes of Menopause Cause Bone Loss
    Osteoporosis in Men: Epidemiology, Pathophysiology, and Clinical Characterization
    Osteoporosis in Childhood and Adolescence
    Glucocorticoid-Induced Osteoporosis
    Adult Scoliosis, Degenerative Disease, and BMD: a Sub-Segmental Analytic Approach
    Mechanisms of Immobilization-induced Bone Loss
    Leptin-Dependent Regulation of Bone Mass
    Thyroid Hormone and the Skeleton
    Osteoporosis in Gastrointestinal, Pancreatic, and Hepatic Disease
    The Skeletal Actions of Parathyroid Hormone in Primary Hyperparathyroidism and in Osteoporosis
    Osteogenesis Imperfecta and Other Defects of Bone Development as Occasional Causes of Adult Osteoporosis
    Osteoporosis Associated with Illnesses and Medications
    Transplantation Osteoporosis
    Osteoporosis Associated with Cancer Therapy
    Osteoporosis Associated with Pregnancy
    Osteoporosis Associated with Rheumatologic Disease
    Oral Bone Loss and Systemic Osteopenia: Potential Treatment and Risks
    Localized Osteoporosis
    Evaluation and Management
    Evaluation of the Patient with Osteoporosis or at Risk for Osteoporosis
    Who Should be Screened: Who Should be Treated?
    Radiology of Osteoporosis
    Clinical Use of Bone Densitometry
    Biochemical Markers of Bone Turnover in Osteoporosis
    The Conundrum of Compliance and Persistence with Oral Bisphosphonates for Postmenopausal Osteoporosis
    An Orthopedic Perspective of Osteoporosis
    Lessons from Bone Histomorphometry on the Mechanism of Action of Osteoporosis Drugs
    Pharmacology and Therapeutics
    Design Considerations for Clinical Investigations of Osteoporosis
    Regulatory Considerations for the Design and Conduct of Osteoporosis Registration Trials
    Evidence-Based Osteoporosis Care
    The Role of Calcium in the Treatment of Osteoporosis
    Vitamin D and its Metabolites and Analogs in the Management of Osteoporosis
    Estrogen Therapy: Prevention and Treatment of Osteoporosis
    Estrogen Analogues: Selective Estrogen Receptor Modulators (SERMs) and Phytoestrogens
    Bisphosphonates: Pharmacology and Use in the Treatment of Osteoporosis
    Calcitonin in Osteoporosis
    Strontium Therapy for Osteoporosis
    Treatment with PTH Peptides
    Growth Hormone and Insulin-like Growth Factors: Potential Applications and Limitations in the Management of Osteoporosis
    New approaches to Osteoporosis Therapeutics

Product details

  • No. of pages: 2016
  • Language: English
  • Copyright: © Academic Press 2007
  • Published: October 17, 2007
  • Imprint: Academic Press
  • eBook ISBN: 9780080553474

About the Editors

Robert Marcus

Robert Marcus
Dr. Marcus is Professor-Emeritus, Stanford University, where he served on the full-time medical faculty for almost 25 years, before joining the Emeritus faculty in 2001. At Stanford, he was located at the Veterans Affairs Medical Center, Palo Alto California, where he served as Director of the Aging Study Unit of the Geriatrics Research, Education, & Clinical Center from 1982-2001. Dr. Marcus enjoyed a long career as a clinical investigator in the fields of bone and mineral metabolism and osteoporosis medicine. His own research interests included diagnosis and therapy of primary hyperpara-thyroidism, interactions of the parathyroid-vitamin D axis with estrogen, age-related changes in the growth hormone-IGF axis, effects of growth hormone replacement for older men and women, metabolic and musculoskeletal effects of resistance exercise in older men and women, adolescent bone acquisition, and osteoporosis therapeutics. Dr. Marcus’ laboratory was a study site for many of the pivotal clinical trials in the osteoporosis field. These include the NIH Post-menopausal Estrogen/Progestin Interventions Trial (PEPI), Merck’s Fracture Intervention Trial (FIT), Lilly’s Multiple Outcomes of Raloxifene Intervention (MORE), and Lilly’s registration trial of recombinant PTH(1-34) in the treatment of postmenopausal women with osteoporosis. In 2001. Dr. Marcus joined the US Affiliate of Eli Lilly & Company to support Lilly’s program in Osteoporosis and Skeletal Medicine. From 2003 until his retirement from Lilly in 2008, Dr. Marcus was the lead physician for the Forteo team at Lilly. He has published more than 150 research papers, editorials, and reviews. Dr. Marcus served as President of the American Society for Bone & Mineral Research in 2000-2001.

Affiliations and Expertise

Professor Emeritus, Department of Medicine, Stanford University School of Medicine, CA, USA

David Feldman

Affiliations and Expertise

Stanford University School of Medicine, Stanford, California, USA

Dorothy Nelson

Affiliations and Expertise

Wayne State University, Detroit, MI, U.S.A.

Clifford Rosen

Dr. Rosen is Professor and Senior Scientists at The Jackson Laboratory, Bar Harbor, Maine, where his group studies the role of insulin-like growth factors on bone and the genetics of osteoporosis in inbred strains of mice. In 2007 he joined the Maine Medical Center Research Institute in Scarborough, Maine. He is also the former Director of the Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor.

Dr. Rosen is a Past President of the American Society of Bone and Mineral Research (ASBMR). He served five years as the First Editor in Chief of the Journal of Clinical Densitometry, the official journal for the International Society of Clinical Densitometry, and currently serves as Associate Editor of the Journal of Bone and Mineral Research. His publications exceed 270 manuscripts published in a wide spectrum of clinical and basic science journals.

Affiliations and Expertise

Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor, Maine, USA

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