Osteoporosis, Two-Volume Set

Osteoporosis, Two-Volume Set

2nd Edition - August 28, 2001

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  • Editors: Robert Marcus, David Feldman, Jennifer Kelsey
  • eBook ISBN: 9780080538266

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Osteoporosis is the most comprehensive, authoritative reference on this disease. Some of the topics covered include basic biology, anatomy, physiology, pathophysiology, preclinical issues, experimental medicine, management, and therapeutics. Written by renowned experts in this field, this book is a must-have for the researcher, the academic clinician, or anyone in the field of bone biology.

Key Features

Key Features
* The source on osteoporosis
* Written by expert investigators in their respective fields
* Each chapter provides timely, comprehensive, and scholarly discussion
* Fully illustrated in color and black & white
* Covers everything from basic anatomy and physiology to diagnosis, management and treatment


Researchers, professionals, and academic clinicians in bone, endocrinology, and related disciplines.

Table of Contents

  • Contributors

    VOLUME 1
    Part I Introduction to Normal Bone Physiology and Pathophysiology

    Chapter 1 The Bone Organ System: Form and Function
    Cassandra A. Lee and Thomas A. Einhorn

    Chapter 2 Osteoblast Biology
    Jane B. Lian and Gary S. Stein

    Chapter 3 Osteoclast Biology
    F. Patrick Ross and Steven L. Teitelbaum

    Chapter 4 The Biochemistry of Bone
    Jayashree A. Gokhale, Pamela Gehron Robey, and Adele L. Boskey

    Chapter 5 Developmental Biology of Bone
    Anthony M. Reginato, Wenfang Wang, and Bjorn R. Olsen

    Chapter 6 Mouse Genetics as a Tool to Study Bone Development and Physiology
    Millan S. Patel and Gerard Karsenty

    Chapter 7 Parathyroid Hormone and Parathyroid Hormone-Related Protein
    Robert A. Nissenson

    Chapter 8 Calcitonin
    Ana O. Hoff, Gilbert J. Cote, and Robert F. Gagel

    Chapter 9 Vitamin D: Biology, Action, and Clinical Implication
    David Feldman, Peter J. Malloy, and Coleman Gross

    Chapter 10 Regulation of Bone Cell Function by Estrogens
    Barry S. Komm and Peter V. N. Bodine

    Chapter 11 Skeletal Biology of Androgens
    Kristine M. Wiren and Eric S. Orwoll

    Chapter 12 Coupling of Bone Resorption and Formation during Bone Remodeling
    Thomas J. Martin and Gideon A. Rodan

    Chapter 13 Cytokines and Bone Remodeling
    Gregory R. Mundy, Babatunde Oyajobi, Kathy Traianedes, Sarah Dallas, and Di Chen

    Chapter 14 Bone Growth Factors
    Xuezhong Qin, Reinhard Gysin, Subburaman Mohan, and David J. Baylink

    Chapter 15 Skeletal Heterogeneity and the Purposes of Bone Remodeling: Implications for the Understanding of Osteoporosis
    A. M. Parfitt

    Chapter 16 Basic Biology of Bisphosphonates
    H. Fleisch

    Part II Structure and Biomechanics

    Chapter 17 Skeletal Development: Mechanical Consequences of Growth, Aging, and Disease
    Marjolein C. H. van der Meulen, Dennis R. Carter, and Gary S. Beaupré

    Chapter 18 Inhibition of Osteopenia by Biophysical Intervention
    Clinton T. Rubin and Kenneth J. McLeod

    Chapter 19 Biomechanics of Age-Related Fractures
    Mary L. Bouxsein

    Part III Epidemiology and Risk Factors

    Chapter 20 Introduction to Epidemiologic Methods
    Jennifer L. Kelsey and MaryFran Sowers

    Chapter 21 Magnitude and Impact of Osteoporosis and Fractures
    L. Joseph Melton III and Cyrus Cooper

    Chapter 22 Race, Ethnicity, and Osteoporosis
    Marie Luz Villa, Lorene Nelson, and Dorothy Nelson

    Chapter 23 Epidemiology of Osteoporosis Fractures: The European Experience
    Chris de Laet and Jonathan Reeve

    Chapter 24 Bone Mineral Acquisition in Utero, during Infancy, and throughout Childhood
    Bonny Specker, Ran Namgung, and Reggie C. Tsang

    Chapter 25 Bone Acquisition in Adolescence
    Jean-Philippe Bonjour and Rene Rizzoli

    Chapter 26 Genetics and Genomics of Osteoporosis
    André G. Uitterlinden, Johannes P. T. M. van Leeuwen, and Huibert A. P. Pols

    Chapter 27 Nutrition and Risk for Osteoporosis
    Robert P. Heaney

    Chapter 28 Physical Activity and Osteoporosis
    Belinda R. Beck, Janet Shaw, and Christine M. Snow

    Chapter 29 Premenopausal Reproduction and Hormonal Characteristics and Risk for Osteoporosis
    MaryFran Sowers

    Chapter 30 Postmenopausal Endogenous and Exogenous Hormones, Degree of Obesity, Thiazide Diuretics, and Risk of Osteoporosis
    Jane A. Cauley and Loran M. Salamone

    Chapter 31 The Effects of Tobacco and Alcohol Use on Bone
    Ego Seeman

    Chapter 32 Falls as Risk Factors for Fractures
    Anne Schwartz, Elizabeth Capezuti, and Jeane Ann Grisso

    Chapter 33 Assessing Fracture Risk
    Charles W. Slemenda, C. Conrad Johnston, and Siu L. Hui

    Chapter 34 Outcomes of Osteoporotic Fractures
    Elizabeth Barrett-Conner and Gail Greendale

    VOLUME 2
    Part IV Pathophysiology

    Chapter 35 The Nature of Osteoporosis
    Robert Marcus and Sharmilla Majumder

    Chapter 36 Local and Systemic Factors in the Pathogenesis of Osteoporosis
    Lawrence R. Raisz

    Chapter 37 Animal Models for in Vivo Experimentation in Osteoporosis Research
    Donald B. Kimmel

    Chapter 38 The TypeI/Type II Model for Involutional Osteoporosis: Update and Modification Based on New Observations
    B. Lawrence Riggs, Sundeep Khosla, and L. Joseph Melton III

    Chapter 39 Bone Remodeling Findings in Osteoporosis
    Robert R. Recker and M. Janet Barger-Lux

    Chapter 40 The Role of Parathyroid Hormone and Vitamin D in the Pathogenesis of Osteoporosis
    John P. Bilezikian and Shonni J. Silverberg

    Chapter 41 Postmenopausal Osteoporosis: How the Hormonal Changes of Menopause Cause Bone Loss
    Roberto Pacifici

    Chapter 42 Osteoporosis in Men: Epidemiology, Pathophysiology, and Clinical Characterization
    Eric S. Orwoll and Robert F. Klein

    Chapter 43 Osteoporosis in Childhood and Adolescence
    Laura K. Bachrach

    Chapter 44 Glucocorticoid-Induced Osteoporosis: Basic Pathological Mechanisms, Clinical Features, and Management in the New Millennium
    Gary M. Leong, Jacqueline R. Center, N. Kathryn Henderson, and John A. Eisman

    Chapter 45 Familial Osteoporosis
    Alan L. Burshell and Steven R. Smith

    Chapter 46 Immobilization Osteopenia
    B. Jenny Kiratli

    Chapter 47 Thyroid Hormone and the Skeleton
    Daniel Baran

    Chapter 48 Osteoporosis in Gastrointestinal, Pancreatic, and Hepatic Diseases
    Daniel D. Bikle

    Chapter 49 Primary Hyperparathyroidism and Hyperparathyroid Bone Disease
    Lorraine A. Fitzpatrick and Hunter Heath III

    Chapter 50 Osteogenesis Imperfecta and Other Defects of Bone Development as Occasional Causes of Adult Osteoporosis
    Jay R. Shapiro

    Chapter 51 Osteoporosis Secondary to Illnesses and Medications
    Adina Schneider and Elizabeth Shane

    Chapter 52 Transplantation Osteoporosis
    Sol Epstein and Elizabeth Shane

    Chapter 53 Osteoporosis Associated with Pregnancy
    Lynn Kohlmeier and Robert Marcus

    Chapter 54 Osteoprosis Associated with Rheumatologic Disorders
    Steven R. Goldring

    Chapter 55 Oral Bone Loss and Systemic Osteopenia
    Marjorie K. Jeffcoat, Michael S. Reddy, and Arthur A. Decarlo

    Part V Evaluation and Management

    Chapter 56 Localized Osteoporosis
    D. J. Schurman, W. J. Maloney, and R. L. Smith

    Chapter 57 The Evaluation of the Patient with Osteoporosis or at Risk for Osteoporosis
    Michael Kleerekoper

    Chapter 58 Imaging of Osteoporosis
    Michael Jergas and Harry K. Genant

    Chapter 59 Clinical Use of Bone Densitometry
    Kenneth G. Faulkner

    Chapter 60 Biochemical Markers of Bone Turnover in Osteoporosis
    P. Garnero and P. D. Delmas

    Chapter 61 Osteoporosis and Its Nonskeletal Consequences: Their Impact on Treatment Decisions
    Deborah T. Gold, Kenneth W. Lyles, Kathy M. Shipp, and Marc K. Drezner

    Chapter 62 An Orthopedic Perspective of Osteoporosis
    Michael H. Heggeness and Kenneth B. Mathis

    Chapter 63 Clinical Use of Bone Biopsy
    P. Chavassieux, M. Arlot, and P. J. Meunier

    Part VI Pharmacology and Therapeutics

    Chapter 64 Design Considerations for Clinical Investigations of Osteoporosis
    Robert P. Heaney

    Chapter 65 Development and Evaluation of New Drugs for Osteoporosis
    Henry Bone

    Chapter 66 Evidence-Based Decision Making in Osteoporosis
    Ann B. Cranney and Gordon H. Guyatt

    Chapter 67 The Role of Calcium in the Treatment of Osteoporosis
    Bess Dawson-Hughes

    Chapter 68 Vitamin D and Its Metabolites in the Management of Osteoporosis
    Ian R. Reid

    Chapter 69 Estrogens and Osteoporosis
    Robert Lindsay and Felicia Cosman

    Chapter 70 Selective Estrogen Receptor Modulators (SERMs)
    Ethel S. Siris and Douglas B. Muchmore

    Chapter 71 Phytoestrogen and Other Phytochemical Effects on Bone
    Richard Prince

    Chapter 72 Bisphosphonates in the Management of Postmenopausal Osteoporosis
    Socrates E. Papapoulous

    Chapter 73 Calcitonin
    Roberto Civitelli

    Chapter 74 Fluoride Therapy for Osteoporosis
    K.-H. William Lau and David J. Baylink

    Chapter 75 A New Perspective on Fluoride Therapy
    Charles Y. C. Pak

    Chapter 76 Androgens and Andogenic Progestins
    Sundeep Khosla

    Chapter 77 Treatment with PTH Peptides
    Lis Mosekilde and Jonathan Reeve

    Chapter 78 Growth Hormone and Insulin-Like Growth Factors: Potential Applications and Limitations in the Management of Osteoporosis
    Christian Wüster and Clifford Rosen

    Chapter 79 New Approaches to Osteoporosis Therapeutics
    S. Aubrey Stoch, Michael Chorev, and Michael Rosenblatt


Product details

  • No. of pages: 1672
  • Language: English
  • Copyright: © Academic Press 2001
  • Published: August 28, 2001
  • Imprint: Academic Press
  • eBook ISBN: 9780080538266

About the Editors

Robert Marcus

Robert Marcus
Dr. Marcus is Professor-Emeritus, Stanford University, where he served on the full-time medical faculty for almost 25 years, before joining the Emeritus faculty in 2001. At Stanford, he was located at the Veterans Affairs Medical Center, Palo Alto California, where he served as Director of the Aging Study Unit of the Geriatrics Research, Education, & Clinical Center from 1982-2001. Dr. Marcus enjoyed a long career as a clinical investigator in the fields of bone and mineral metabolism and osteoporosis medicine. His own research interests included diagnosis and therapy of primary hyperpara-thyroidism, interactions of the parathyroid-vitamin D axis with estrogen, age-related changes in the growth hormone-IGF axis, effects of growth hormone replacement for older men and women, metabolic and musculoskeletal effects of resistance exercise in older men and women, adolescent bone acquisition, and osteoporosis therapeutics. Dr. Marcus’ laboratory was a study site for many of the pivotal clinical trials in the osteoporosis field. These include the NIH Post-menopausal Estrogen/Progestin Interventions Trial (PEPI), Merck’s Fracture Intervention Trial (FIT), Lilly’s Multiple Outcomes of Raloxifene Intervention (MORE), and Lilly’s registration trial of recombinant PTH(1-34) in the treatment of postmenopausal women with osteoporosis. In 2001. Dr. Marcus joined the US Affiliate of Eli Lilly & Company to support Lilly’s program in Osteoporosis and Skeletal Medicine. From 2003 until his retirement from Lilly in 2008, Dr. Marcus was the lead physician for the Forteo team at Lilly. He has published more than 150 research papers, editorials, and reviews. Dr. Marcus served as President of the American Society for Bone & Mineral Research in 2000-2001.

Affiliations and Expertise

Professor Emeritus, Department of Medicine, Stanford University School of Medicine, CA, USA

David Feldman

Affiliations and Expertise

Stanford University School of Medicine, Stanford, California, USA

Jennifer Kelsey

Affiliations and Expertise

Stanford University, California, U.S.A.

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