Osteoporosis is the most comprehensive, authoritative reference on this disease. Some of the topics covered include basic biology, anatomy, physiology, pathophysiology, preclinical issues, experimental medicine, management, and therapeutics. Written by renowned experts in this field, this book is a must-have for the researcher, the academic clinician, or anyone in the field of bone biology.

Key Features

Key Features * The source on osteoporosis * Written by expert investigators in their respective fields * Each chapter provides timely, comprehensive, and scholarly discussion * Fully illustrated in color and black & white * Covers everything from basic anatomy and physiology to diagnosis, management and treatment


Researchers, professionals, and academic clinicians in bone, endocrinology, and related disciplines.

Table of Contents

Contributors Preface VOLUME 1 Part I Introduction to Normal Bone Physiology and Pathophysiology Chapter 1 The Bone Organ System: Form and Function Cassandra A. Lee and Thomas A. Einhorn Chapter 2 Osteoblast Biology Jane B. Lian and Gary S. Stein Chapter 3 Osteoclast Biology F. Patrick Ross and Steven L. Teitelbaum Chapter 4 The Biochemistry of Bone Jayashree A. Gokhale, Pamela Gehron Robey, and Adele L. Boskey Chapter 5 Developmental Biology of Bone Anthony M. Reginato, Wenfang Wang, and Bjorn R. Olsen Chapter 6 Mouse Genetics as a Tool to Study Bone Development and Physiology Millan S. Patel and Gerard Karsenty Chapter 7 Parathyroid Hormone and Parathyroid Hormone-Related Protein Robert A. Nissenson Chapter 8 Calcitonin Ana O. Hoff, Gilbert J. Cote, and Robert F. Gagel Chapter 9 Vitamin D: Biology, Action, and Clinical Implication David Feldman, Peter J. Malloy, and Coleman Gross Chapter 10 Regulation of Bone Cell Function by Estrogens Barry S. Komm and Peter V. N. Bodine Chapter 11 Skeletal Biology of Androgens Kristine M. Wiren and Eric S. Orwoll Chapter 12 Coupling of Bone Resorption and Formation during Bone Remodeling Thomas J. Martin and Gideon A. Rodan Chapter 13 Cytokines and Bone Remodeling Gregory R. Mundy, Babatunde Oyajobi, Kathy Traianedes, Sarah Dallas, and Di Chen Chapter 14 Bone Growth Factors Xuezhong Qin, Reinhard Gysin, Subburaman


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© 2001
Academic Press
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About the editors

Robert Marcus

Dr. Marcus is Professor-Emeritus, Stanford University, where he served on the full-time medical faculty for almost 25 years, before joining the Emeritus faculty in 2001. At Stanford, he was located at the Veterans Affairs Medical Center, Palo Alto California, where he served as Director of the Aging Study Unit of the Geriatrics Research, Education, & Clinical Center from 1982-2001. Dr. Marcus enjoyed a long career as a clinical investigator in the fields of bone and mineral metabolism and osteoporosis medicine. His own research interests included diagnosis and therapy of primary hyperpara-thyroidism, interactions of the parathyroid-vitamin D axis with estrogen, age-related changes in the growth hormone-IGF axis, effects of growth hormone replacement for older men and women, metabolic and musculoskeletal effects of resistance exercise in older men and women, adolescent bone acquisition, and osteoporosis therapeutics. Dr. Marcus’ laboratory was a study site for many of the pivotal clinical trials in the osteoporosis field. These include the NIH Post-menopausal Estrogen/Progestin Interventions Trial (PEPI), Merck’s Fracture Intervention Trial (FIT), Lilly’s Multiple Outcomes of Raloxifene Intervention (MORE), and Lilly’s registration trial of recombinant PTH(1-34) in the treatment of postmenopausal women with osteoporosis. In 2001. Dr. Marcus joined the US Affiliate of Eli Lilly & Company to support Lilly’s program in Osteoporosis and Skeletal Medicine. From 2003 until his retirement from Lilly in 2008, Dr. Marcus was the lead physician for the Forteo team at Lilly. He has published more than 150 research papers, editorials, and reviews. Dr. Marcus served as President of the American Society for Bone & Mineral Research in 2000-2001.

Affiliations and Expertise

Emeritus, Department of Medicine, Stanford University School of Medicine, CA, USA

David Feldman

Affiliations and Expertise

Stanford University School of Medicine, Stanford, California, USA

Jennifer Kelsey

Affiliations and Expertise

Stanford University, California, U.S.A.


@from:Praise for the First Edition @quote:"...a textbook focused solely on this condition and encompassing this diversity of research has been lacking. This book does a terrific job of filling the gap... All the chapters are authoritative and include up-to-date references... Osteoporosis is quite comprehensive..." @source:--NEW ENGLAND JOURNAL OF MEDICINE @qu:"The editors have managed to produce a work which is interesting, comprehensive and up-to-date..." @source:--JOURNAL OF BONE AND JOINT SURGERY