Osteoporosis in Men - 2nd Edition - ISBN: 9780123746023, 9780080923468

Osteoporosis in Men

2nd Edition

The Effects of Gender on Skeletal Health

Editors: Eric Orwoll John Bilezikian Dirk Vanderschueren
eBook ISBN: 9780080923468
Hardcover ISBN: 9780123746023
Imprint: Academic Press
Published Date: 17th November 2009
Page Count: 741
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Since the publication of the first edition, the U.S. Surgeon General released the first-ever report on bone health and osteoporosis in October 2004. This report focuses even more attention on the devastating impact osteoporosis has on millions of lives. According to the National Osteoporosis Foundation, 2 million American men have osteoporosis, and another 12 million are at risk for this disease. Yet despite the large number of men affected, the lack of awareness by doctors and their patients puts men at a higher risk that the condition may go undiagnosed and untreated. It is estimated that one-fifth to one-third of all hip fractures occur in men.

This second edition brings on board John Bilezikian and Dirk Vanderschueren as editors with Eric Orwoll. The table of contents is more than doubling with 58 planned chapters. The format is larger – 8.5 x 11. This edition  of Osteoporosis in Men brings together even more eminent investigators and clinicians to interpret developments in this growing field, and describe state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy.

Key Features

  • Brings together more eminent investigators and clinicians to interpret developments in this growing field.
  • Describes state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy.
  • There is no book on the market that covers osteoporosis in men as comprehensively as this book.


Academic, medical, and pharmaceutical researchers in bone biology, endocrinology, and rheumatology; Medical researchers in pediatrics, internal medicine, orthopedics, primary care, geriatrics, obstetrics and gynecology, oncology, and nephrology.

Table of Contents

Section 1 – Essentials of bone biology

  1. The Biochemistry of Bone: Composition and Organization
  2. Adele L. Boskey

  3. Bone Remodeling: Cellular Activities in Bone
  4. David W. Dempster, Hua Zhou, Shi Shou Lu

  5. Assessment of Bone Turnover Using Biochemical Markers
  6. Patrick Garnero, Pawel Szulc

  7. Fundamentals of Mineral Homeostasis
  8. David A. Hanley, Shawn K. Davison

  9. The Mechanical Properties of Bone
  10. David P. Fyhrie

  11. Assessment of Bone Architecture
  12. Thomas F. Lang


    Section 2 – Development and growth of the male skeleton

  13. Skeletal Growth in Males
  14. Qingju Wang, Ego Seeman

  15. Pubertal Growth of the Male Skeleton
  16. Vincent Gilsanz, Stefano Mora

  17. The Effects of Sex Steroids on Bone Growth
  18. Giampiero I. Baroncelli, Silvano Bertelloni

  19. Nutritional Basis of Skeletal Growth
  20. Connie M. Weaver, Elizabeth Haney

  21. Physical Activity and Skeletal Growth
  22. Heather M. Macdonald, Heather A. McKay, Melonie Burrows


    Section 3 – Skeletal genetics

  23. The Genetics of Peak Bone Mass
  24. Luigi Gennari, Robert F. Klein, Serge Ferrari

    Section 4 – Aging and the male skeleton

  25. Age-Related Changes in Bone Remodeling and Micro Architecture
  26. Roger Zebaze, Ego Seeman

  27. Markers of Bone Remodeling and the Aging Skeleton
  28. Serge Cremers, Christian Meier, Markus J. Seibel

  29. Alterations in Mineral Metabolism in the Aging Male
  30. Shonni J. Silverberg, Bismruta Misra

  31. Change in Bone Size and Geometry with Aging
  32. Pawel Szulc

  33. Aging and Bone Density
  34. Steven Boonen, Filip Callewaert, Katrien Venken, Dirk Vanderschueren

  35. The Effect of Age on Material Properties
  36. Charles H. Turner, Matt Allen, David Burr

    Section 5, Nutritional issues

  37. Calcium, Bone Strength and Fractures
  38. Laura A.G. Armas, David P. Heaney, Joan M. Lappe

  39. Vitamin D and Bone
  40. Roger Bouillon, Christa Maes, Lieve Verlinden, Geert Carmeliet, Annemieke Verstuyf

  41. Role of Dietary Protein in Bone Growth and Bone Loss
  42. Rene Rizzoli


    Section 6 – Sex steroids and the skeleton in men

  43. The Molecular Biology of Sex Steroids in Bone: Similarities and Differences Among the Sexes
  44. Stavroula Kousteni

  45. Estrogen and the Skeleton – Rodents
  46. Dirk Vanderschueren, Katrien Venken, Filip Callewaert, Steven Boonen

  47. Estrogen and the Skeleton – Humans
  48. Liesbeth Vandenput, Claes Ohlsson

  49. Androgens and the Skeleton – Animal Models
  50. Kristine Wiren, Eric Orwoll

  51. Androgens and the Skeleton – Humans
  52. Benjamin Z. Leder

  53. Androgen Effects on the Skeletal Muscle
  54. Shalender Bhasin, Rajan Singh, Ravi Jasuja, Thomas W. Storer

    Section 7 – Fractures in men

  55. Epidemiology of Fractures
  56. Shreyasee Amin

  57. Individualized Progress of Fractures in Men
  58. Tuan V. Nguyen , John A. Eisman

  59. Physical Activity, Physical Function and Fall and Fracture Risk in Older Men
  60. Peggy Mannen Cawthon, Lynn Marshall

  61. Economic Impact of Osteoporotic Fractures (vs women)
  62. Terence O’Neill

  63. Adverse Health Outcomes in Men with Osteoporosis
  64. Deborah T. Gold, Stuart L. Silverman


    Section 8. Metabolic bone disease in men

  65. Idiopathic Osteoporosis
  66. Jean-Marc Kaufman, Bruno Lepauw, Youri Taes, Stefan Goemeare

  67. Glucocorticoid Induced Osteoporosis
  68. Andrea Giustina, Gherardo Mazziotti

  69. Testicular Dysfunction
  70. David J. Handelsman, Christian Meier, Markus J. Seibel

  71. Alcohol and Bone
  72. Neil Binkley

  73. Transplantation Osteoporosis
  74. Elizabeth Shane, Juliet E. Compston, Emily Stein

  75. Management of Fractures in Men with Impaired Renal Function
  76. Paul D. Miller

  77. Hyperparathyroidism
  78. John P. Bilezikian, Claudio Marccoci

  79. Hypercalciuria
  80. Murray J. Favus

  81. The Skeletal Phenotype of the Male Athlete
  82. Clifford J. Rosen, Ann E. Maloney

  83. Inherited and Related Disorders of Bone Matrix Synthesis in Men
  84. Jay R. Shapiro


    Section 9 – Diagnostic approach

  85. Dual-Energy X-ray Absorptiometry (DXA) in Men
  86. Neil C. Binkley, Robert A. Adler

  87. Quantitative Ultrasound Diagnosis of Osteoporosis in Men
  88. Robert A. Adler, Neil C. Binkley

  89. Advanced Structural Assessment of Bone Using CT and MRI
  90. X. Edward Guo, X. Sherry Liu, Felix W. Wehrli

  91. Vertebral Fracture Assessments
  92. Piet Geusens, Willem Lems

  93. The Use of Bone Biopsies in the Diagnosis of Male Osteoporosis
  94. Erik F. Eriksen, Johan Halse

  95. Overall diagnostic strategy
  96. Eric Orwoll

    Section 10 – Therapy

  97. Diagnostic Thresholds for Osteoporosis in Men
  98. John A. Kanis, Anders Oden, Helena Johansson, Eugene V. McCloskey

  99. Cost-Effectiveness of Interventions to Reduce Osteoporosis-Related Fractures in Men: Current Data, Controversies, and Challenges
  100. John T. Schoesboe

  101. Nutritional Therapy for Skeletal Health in Men
  102. Deborah E. Sellmeyer, Diana M. Antoniucci

  103. Exercise Programs for Patients with Osteoporosis
  104. Dieter Felsenberg, Martin Runge

  105. Calcitonin: History, Physiology, Pathophysiology and Therapeutic Applications
  106. Sunil J. Wimalawansa

  107. Treatment of Male Osteoporosis with Bisphosphonates
  108. Socrates E. Papapoulos, Andrea Giusti

  109. Treatment of Male Osteoporosis with Parathyroid Hormone
  110. Monica Giotra, Felicia Cosman, John P. Bilezikian

  111. Testosterone Therapy for Osteoporosis in Men

Kishore M. Lakshman, Andre B. Araujo, Shalendar Bhasin

57. Future Therapies: Strontium, SERMs, SARMs and New Therapies on the Horizon

Ghada El-Hajj Fuleihan, Mahmoud Tabbal


No. of pages:
© Academic Press 2010
Academic Press
eBook ISBN:
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About the Editor

Eric Orwoll

Professor of Medicine and Director, Clinical Research Center, Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health & Science University, Portland, Oregon

Affiliations and Expertise

Oregon Health Sciences University, Portland, Oregon, USA

John Bilezikian

John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700.

Affiliations and Expertise

Columbia University, New York, New York, U.S.A.

Dirk Vanderschueren

Professor of Medicine, Division of Endocrinology, Department of Internal Medicine, UZ Gasthuisberg, Leuven, Belgium

Affiliations and Expertise

UZ Gasthuisberg, Leuven, Belgium


"The editors of Osteoporosis in Men, Second Edition have produced a comprehensive compendium about osteoporosis as it relates to men. An established group of experts has contributed to the second edition of this excellent book. The topics range from the basics of osteoporosis to sections on growth of the skeleton, aging, importance of nutrition, sex hormones, and the development of the disorder. Key sections of clinical relevance including diagnosis and treatment of osteoporosis in men are covered in depth. This book will serve as an excellent resource for established clinicians and investigators as well as for students and fellows."

--Richard Eastell, MD, FRCP, FRCPath, FMedSci, Professor of Bone Metabolism, Director of the NIHR Bone Biomedical Research Unit, Centre for Biomedical Research, Northern General Hospital, Sheffield, South Yorkshire, United Kingdom

"The 10 sections and total of 57 informative chapters in the second edition of the text Osteoporosis in Men constitute an impressive body of up-to-date information by leading experts on this important topic. The text is particularly useful because of its breadth extending from basic bone biology and environmental factors affecting skeletal development in men to clinical chapters on pathophysiology, diagnosis, and therapy. The editors have provided a comprehensive yet practical approach to the topic which makes the text useful to a broad potential audience ranging from trainees to established leaders in the field."

-- John T. Potts, Jr., MD, Director of Research and Physician-in-Chief emeritus, Massachusetts General Hospital, Jackson Distinguished Professor of Clinical Medicine, Harvard Medical School, Boston, MA, USA

"This thorough and comprehensive book integrates new, accessible, and informative material in the field. It will help investigators, as well as practitioners and students, to improve their understanding of male skeletal health and male skeletal loss. The additional knowledge, assembled in such a readable manner, should help us achieve one of our ultimate goals, namely better care of men with osteoporosis."

--Gerolamo Bianchi, MD, Department of Locomotor System, Division of Rheumatology, Azienda Sanitaria Genovese, Genova, Italy

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