Osteoporosis in Men

Osteoporosis in Men

The Effects of Gender on Skeletal Health

2nd Edition - November 17, 2009

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  • Editors: Eric Orwoll, John Bilezikian, Dirk Vanderschueren
  • eBook ISBN: 9780080923468
  • Hardcover ISBN: 9780123746023

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Since the publication of the first edition, the U.S. Surgeon General released the first-ever report on bone health and osteoporosis in October 2004. This report focuses even more attention on the devastating impact osteoporosis has on millions of lives. According to the National Osteoporosis Foundation, 2 million American men have osteoporosis, and another 12 million are at risk for this disease. Yet despite the large number of men affected, the lack of awareness by doctors and their patients puts men at a higher risk that the condition may go undiagnosed and untreated. It is estimated that one-fifth to one-third of all hip fractures occur in men. This second edition brings on board John Bilezikian and Dirk Vanderschueren as editors with Eric Orwoll. The table of contents is more than doubling with 58 planned chapters. The format is larger – 8.5 x 11. This edition  of Osteoporosis in Men brings together even more eminent investigators and clinicians to interpret developments in this growing field, and describe state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy.

Key Features

  • Brings together more eminent investigators and clinicians to interpret developments in this growing field
  • Describes state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy
  • There is no book on the market that covers osteoporosis in men as comprehensively as this book


Academic, medical, and pharmaceutical researchers in bone biology, endocrinology, and rheumatology; Medical researchers in pediatrics, internal medicine, orthopedics, primary care, geriatrics, obstetrics and gynecology, oncology, and nephrology

Table of Contents

  • Section 1 Essentials of bone biology
    1. The Biochemistry of Bone: Composition and Organization
    Adele L. Boskey
    2. Bone Remodeling: Cellular Activities in Bone
    David W. Dempster, Hua Zhou, Shi Shou Lu
    3. Assessment of Bone Turnover Using Biochemical Markers
    Patrick Garnero, Pawel Szulc
    4. Fundamentals of Mineral Homeostasis
    David A. Hanley, Shawn K. Davison
    5. The Mechanical Properties of Bone
    David P. Fyhrie
    6. Assessment of Bone Architecture
    Thomas F. Lang

    Section 2 Development and growth of the male skeleton
    7. Skeletal Growth in Males
    Qingju Wang, Ego Seeman
    8. Pubertal Growth of the Male Skeleton
    Vincent Gilsanz, Stefano Mora
    9. The Effects of Sex Steroids on Bone Growth
    Giampiero I. Baroncelli, Silvano Bertelloni
    10. Nutritional Basis of Skeletal Growth
    Connie M. Weaver, Elizabeth Haney
    11. Physical Activity and Skeletal Growth
    Heather M. Macdonald, Heather A. McKay, Melonie Burrows

    Section 3 Skeletal genetics
    12. The Genetics of Peak Bone Mass
    Luigi Gennari, Robert F. Klein, Serge Ferrari

    Section 4 Aging and the male skeleton
    13. Age-Related Changes in Bone Remodeling and Micro Architecture
    Roger Zebaze, Ego Seeman
    14. Markers of Bone Remodeling and the Aging Skeleton
    Serge Cremers, Christian Meier, Markus J. Seibel
    15. Alterations in Mineral Metabolism in the Aging Male
    Shonni J. Silverberg, Bismruta Misra
    16. Change in Bone Size and Geometry with Aging
    Pawel Szulc
    17. Aging and Bone Density
    Steven Boonen, Filip Callewaert, Katrien Venken, Dirk Vanderschueren
    18. The Effect of Age on Material Properties
    Charles H. Turner, Matt Allen, David Burr

    Section 5 Nutritional issues
    19. Calcium, Bone Strength and Fractures
    Laura A.G. Armas, David P. Heaney, Joan M. Lappe
    20. Vitamin D and Bone
    Roger Bouillon, Christa Maes, Lieve Verlinden, Geert Carmeliet, Annemieke Verstuyf
    21. Role of Dietary Protein in Bone Growth and Bone Loss
    Rene Rizzoli

    Section 6 Sex steroids and the skeleton in men
    22. The Molecular Biology of Sex Steroids in Bone: Similarities and Differences Among the Sexes
    Stavroula Kousteni
    23. Estrogen and the Skeleton – Rodents
    Dirk Vanderschueren, Katrien Venken, Filip Callewaert, Steven Boonen
    24. Estrogen and the Skeleton – Humans
    Liesbeth Vandenput, Claes Ohlsson
    25. Androgens and the Skeleton – Animal Models
    Kristine Wiren, Eric Orwoll
    26. Androgens and the Skeleton – Humans
    Benjamin Z. Leder
    27. Androgen Effects on the Skeletal Muscle
    Shalender Bhasin, Rajan Singh, Ravi Jasuja, Thomas W. Storer

    Section 7 Fractures in men
    28. Epidemiology of Fractures
    Shreyasee Amin
    29. Individualized Progress of Fractures in Men
    Tuan V. Nguyen , John A. Eisman
    30. Physical Activity, Physical Function and Fall and Fracture Risk in Older Men
    Peggy Mannen Cawthon, Lynn Marshall
    31. Economic Impact of Osteoporotic Fractures (vs women)
    Terence O’Neill
    32. Adverse Health Outcomes in Men with Osteoporosis
    Deborah T. Gold, Stuart L. Silverman

    Section 8. Metabolic bone disease in men
    33. Idiopathic Osteoporosis
    Jean-Marc Kaufman, Bruno Lepauw, Youri Taes, Stefan Goemeare
    34. Glucocorticoid Induced Osteoporosis
    Andrea Giustina, Gherardo Mazziotti
    35. Testicular Dysfunction
    David J. Handelsman, Christian Meier, Markus J. Seibel
    36. Alcohol and Bone
    Neil Binkley
    37. Transplantation Osteoporosis
    Elizabeth Shane, Juliet E. Compston, Emily Stein
    38. Management of Fractures in Men with Impaired Renal Function
    Paul D. Miller
    39. Hyperparathyroidism
    John P. Bilezikian, Claudio Marccoci
    40. Hypercalciuria
    Murray J. Favus
    41. The Skeletal Phenotype of the Male Athlete
    Clifford J. Rosen, Ann E. Maloney
    42. Inherited and Related Disorders of Bone Matrix Synthesis in Men
    Jay R. Shapiro

    Section 9 Diagnostic approach
    43. Dual-Energy X-ray Absorptiometry (DXA) in Men
    Neil C. Binkley, Robert A. Adler
    44. Quantitative Ultrasound Diagnosis of Osteoporosis in Men
    Robert A. Adler, Neil C. Binkley
    45. Advanced Structural Assessment of Bone Using CT and MRI
    X. Edward Guo, X. Sherry Liu, Felix W. Wehrli
    46. Vertebral Fracture Assessments
    Piet Geusens, Willem Lems
    47. The Use of Bone Biopsies in the Diagnosis of Male Osteoporosis
    Erik F. Eriksen, Johan Halse
    48. Overall diagnostic strategy
    Eric Orwoll

    Section 10 Therapy
    49. Diagnostic Thresholds for Osteoporosis in Men
    John A. Kanis, Anders Oden, Helena Johansson, Eugene V. McCloskey
    50. Cost-Effectiveness of Interventions to Reduce Osteoporosis-Related Fractures in Men: Current Data, Controversies, and Challenges
    John T. Schoesboe
    51. Nutritional Therapy for Skeletal Health in Men
    Deborah E. Sellmeyer, Diana M. Antoniucci
    52. Exercise Programs for Patients with Osteoporosis
    Dieter Felsenberg, Martin Runge
    53. Calcitonin: History, Physiology, Pathophysiology and Therapeutic Applications
    Sunil J. Wimalawansa
    54. Treatment of Male Osteoporosis with Bisphosphonates
    Socrates E. Papapoulos, Andrea Giusti
    55. Treatment of Male Osteoporosis with Parathyroid Hormone
    Monica Giotra, Felicia Cosman, John P. Bilezikian
    56. Testosterone Therapy for Osteoporosis in Men
    Kishore M. Lakshman, Andre B. Araujo, Shalendar Bhasin
    57. Future Therapies: Strontium, SERMs, SARMs and New Therapies on the Horizon
    Ghada El-Hajj Fuleihan, Mahmoud Tabbal

Product details

  • No. of pages: 741
  • Language: English
  • Copyright: © Academic Press 2009
  • Published: November 17, 2009
  • Imprint: Academic Press
  • eBook ISBN: 9780080923468
  • Hardcover ISBN: 9780123746023

About the Editors

Eric Orwoll

Professor of Medicine and Director, Clinical Research Center, Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health & Science University, Portland, Oregon

Affiliations and Expertise

Oregon Health Sciences University, Portland, Oregon, USA

John Bilezikian

John P. Bilezikian, MD, the Dorothy L. and Daniel H. Silberberg Professor of Medicine and Professor of Pharmacology at the College of Physicians & Surgeons, Columbia University is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. Dr. Bilezikian received his undergraduate training at Harvard College and his medical training at the College of Physicians & Surgeons. He completed four years of house staff training (internship, residency and Chief Residency) on the Medical Service at Columbia Presbyterian Medical Center. Dr. Bilezikian received his training in Metabolic Bone Diseases and in Endocrinology at the NIH in the Mineral Metabolism Branch under the tutelage of Dr. Gerald Aurbach. Dr. Bilezikian belongs to a number of professional societies including the American Society for Bone and Mineral Research, of which he served as President, 1995-1996 and the International Society of Clinical Densitometry, of which he served as President, 1999-2001. He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present). He is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). His books include Editor-in-Chief of The Parathyroids [1994, 2001, 2014], and co-editor of The Aging Skeleton (1999), Dynamics of Bone and Cartilage Metabolism (1999, 2006), Principles of Bone Biology (1996, 2002, 2008) and Osteoporosis in Men (2010). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013). He is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700.

Affiliations and Expertise

Columbia University, New York, New York, U.S.A.

Dirk Vanderschueren

Professor of Medicine, Division of Endocrinology, Department of Internal Medicine, UZ Gasthuisberg, Leuven, Belgium

Affiliations and Expertise

UZ Gasthuisberg, Leuven, Belgium

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